Paradoxical Rules of Spike Train Decoding Revealed at the Sensitivity Limit of Vision

Lina Smeds, Daisuke Takeshita, Tuomas Turunen, Jussi Samuli Tiihonen, Johan Westö, Nataliia Martyniuk, Aarni Juhani Seppänen, Petri Ala-Laurila

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Abstrakti

All sensory information is encoded in neural spike
trains. It is unknown how the brain utilizes this neural
code to drive behavior. Here, we unravel the decoding
rules of the brain at the most elementary level by
linking behavioral decisions to retinal output signals
in a single-photon detection task. A transgenic
mouse line allowed us to separate the two primary
retinal outputs, ON and OFF pathways, carrying
information about photon absorptions as increases
and decreases in spiking, respectively. Wemeasured
the sensitivity limit of rods and the most sensitive
ON and OFF ganglion cells and correlated these
results with visually guided behavior using markerless
head and eye tracking. We show that behavior
relies only on the ON pathway even when the OFF
pathway would allow higher sensitivity. Paradoxically,
behavior does not rely on the spike code with
maximal information but instead relies on a decoding
strategy based on increases in spiking.
Alkuperäiskielienglanti
LehtiNeuron
Vuosikerta104
Numero3
Sivut576-+
Sivumäärä23
ISSN0896-6273
DOI - pysyväislinkit
TilaJulkaistu - 6 marraskuuta 2019
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

  • 3112 Neurotieteet

Palkinnot

Best Journal Article Prize (PhD student category) 2019

Smeds, Lina (Vastaanottaja), 2020

Palkinto: Palkinnot ja kunnianosoitukset

Siteeraa tätä

Smeds, L., Takeshita, D., Turunen, T., Tiihonen, J. S., Westö, J., Martyniuk, N., Seppänen, A. J., & Ala-Laurila, P. (2019). Paradoxical Rules of Spike Train Decoding Revealed at the Sensitivity Limit of Vision. Neuron, 104(3), 576-+. https://doi.org/10.1016/j.neuron.2019.08.005