Personalized Repetitive Transcranial Magnetic Stimulation for Depression

Juha Gogulski, Jessica M. Ross, Austin Talbot, Christopher Cline, Francesco Donati, Saachi Munot, Naryeong Kim, Ciara Gibbs, Nikita Bastin, Jessica Yang, Christopher Minasi, Manjima Sarkar, Jade Truong, Corey J. Keller

Tutkimustuotos: ArtikkelijulkaisuKatsausartikkelivertaisarvioitu

Abstrakti

Personalized treatments are gaining momentum across all fields of medicine. Precision medicine can be applied to neuromodulatory techniques, in which focused brain stimulation treatments such as repetitive transcranial magnetic stimulation (rTMS) modulate brain circuits and alleviate clinical symptoms. rTMS is well tolerated and clinically effective for treatment-resistant depression and other neuropsychiatric disorders. Despite its wide stimulation parameter space (location, angle, pattern, frequency, and intensity can be adjusted), rTMS is currently applied in a one-size-fits-all manner, potentially contributing to its suboptimal clinical response (w50%). In this review, we examine components of rTMS that can be optimized to account for interindividual variability in neural function and anatomy. We discuss current treatment options for treatment-resistant depression, the neural mechanisms thought to underlie treatment, targeting strategies, stimulation parameter selection, and adaptive closed-loop treatment. We conclude that a better understanding of the wide and modifiable parameter space of rTMS will greatly improve the clinical outcome.
Alkuperäiskielienglanti
LehtiBiological Psychiatry: Cognitive Neuroscience and Neuroimaging
Vuosikerta8
Numero4
Sivut351-360
Sivumäärä10
ISSN2451-9022
DOI - pysyväislinkit
TilaJulkaistu - huhtik. 2023
OKM-julkaisutyyppiA2 Katsausartikkeli tieteellisessä aikakauslehdessä

Tieteenalat

  • 3124 Neurologia ja psykiatria

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