Preoperative hemoglobin count and prognosis of esophageal cancer, a population-based nationwide study in Finland

on behalf of the FINEGO group, Ella M.K. Jokela, Joonas H. Kauppila, Olli Helminen, Mika Helmiö, Heikki Huhta, Raija Kallio, Vesa Koivukangas, Arto Kokkola, Simo Laine, Elina Lietzen, Sanna Meriläinen, Pasi Ohtonen, Vesa-Matti Pohjanen, Tuomo Rantanen, Ari Ristimäki, Jari V. Räsänen, Juha Saarnio, Vesa Toikkanen, Tuula TyrväinenAntti Valtola

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Abstrakti

Background: The prognostic value of preoperative hemoglobin in patients undergoing esophagectomy is unknown. The aim of this study was to examine whether preoperative hemoglobin is associated with prognosis in patients undergoing esophagectomy for cancer. Materials and methods: This was a population-based nationwide retrospective cohort study in Finland, using Finnish National Esophago-Gastric Cancer Cohort (FINEGO). Esophagectomy patients with available preoperative hemoglobin measurement were included. Multivariable cox regression provided hazard ratios (HR) with 95% confidence intervals (CI), adjusted for calendar period of surgery, age at surgery, sex, comorbidity (Charlson Comorbidity Index), tumor histology, tumor stage, neoadjuvant therapy, type of surgery (minimally invasive or open) and annual hospital volume. Results: Of the 1313 patients, 932 (71.0%) were men and 799 (60.9%) had esophageal adenocarcinoma. Overall all-cause mortality was significantly higher in the lowest hemoglobin count tertile (HR 1.26 (1.07–1.47)) compared to the highest tertile, but this association was attenuated after adjustment for confounding. No differences were found between the preoperative hemoglobin groups in the adjusted analyses of 90-day all-cause, 5-year all-cause, and 5-year cancer-specific mortality. Conclusion: In this population-based nationwide study, preoperative hemoglobin count had no independent prognostic significance in esophageal cancer.

Alkuperäiskielienglanti
LehtiEuropean Journal of Surgical Oncology
ISSN0748-7983
DOI - pysyväislinkit
TilaE-pub ahead of print - 2021
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Lisätietoja

Funding Information:
This study was funded by the Finnish Cancer Foundation, Sigrid Juselius Foundation, P?ivikki and Sakari Sohlberg Foundation, and Orion Research Foundation. The funders had no role in designing the study, data collection, analysis, writing the manuscript, or submitting the manuscript to publication.

Funding Information:
This study was funded by the Finnish Cancer Foundation , Sigrid Juselius Foundation , Päivikki and Sakari Sohlberg Foundation , and Orion Research Foundation . The funders had no role in designing the study, data collection, analysis, writing the manuscript, or submitting the manuscript to publication.

Publisher Copyright:
© 2021

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