Projekteja vuodessa
Abstrakti
To address the variability in prevalence estimates and inconsistencies in potential risk factors for poststroke cognitive impairment (PSCI) using a standardized approach and individual participant data (IPD) from international cohorts in the Stroke and Cognition Consortium (STROKOG) consortium.
METHODS:
We harmonized data from 13 studies based in 8 countries. Neuropsychological test scores 2 to 6 months after stroke or TIA and appropriate normative data were used to calculate standardized cognitive domain scores. Domain-specific impairment was based on percentile cutoffs from normative groups, and associations between domain scores and risk factors were examined with 1-stage IPD meta-analysis.
RESULTS:
In a combined sample of 3,146 participants admitted to hospital for stroke (97%) or TIA (3%), 44% were impaired in global cognition and 30% to 35% were impaired in individual domains 2 to 6 months after the index event. Diabetes mellitus and a history of stroke were strongly associated with poorer cognitive function after covariate adjustments; hypertension, smoking, and atrial fibrillation had weaker domain-specific associations. While there were no significant differences in domain impairment among ethno-racial groups, some interethnic differences were found in the effects of risk factors on cognition.
CONCLUSIONS:
This study confirms the high prevalence of PSCI in diverse populations, highlights common risk factors, in particular diabetes mellitus, and points to ethno-racial differences that warrant attention in the development of prevention strategies.
Alkuperäiskieli | englanti |
---|---|
Lehti | Neurology |
Vuosikerta | 93 |
Numero | 24 |
Sivut | e2257-e2271 |
Sivumäärä | 16 |
ISSN | 0028-3878 |
DOI - pysyväislinkit | |
Tila | Julkaistu - jouluk. 2019 |
OKM-julkaisutyyppi | A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu |
Tieteenalat
- 3124 Neurologia ja psykiatria
- 515 Psykologia
Projektit
- 1 Aktiivinen
-
STROKOG: Stroke and Cognition Consortium
STROKOG Consortium (Projektinjohtaja), Jokinen, H. (Osallistuja), Melkas, S. (Osallistuja), Erkinjuntti, T. J. (Osallistuja) & Laakso, H. (Osallistuja)
01/05/2016 → 31/12/2024
Projekti: Tutkimusprojekti