Profiling persistent tubercule bacilli from patient sputa during therapy predicts early drug efficacy

Isobella Honeyborne; Timothy D. McHugh; Iitu Kuittinen; Anna Cichonska; Dimitrios Evangelopoulos; Katharina Ronacher; Paul D. van Helden; Stephen H. Gillespie; Delmiro Fernandez-Reyes; Gerhard Walzl; Juho Rousu; Philip D. Butcher; Simon J. Waddell

doi:10.1186/s12916-016-0609-3

Profiling persistent tubercule bacilli from patient sputa during therapy predicts early drug efficacy

Isobella Honeyborne, Timothy D. McHugh, Iitu Kuittinen, Anna Cichonska, Dimitrios Evangelopoulos, Katharina Ronacher, Paul D. van Helden, Stephen H. Gillespie, Delmiro Fernandez-Reyes, Gerhard Walzl, Juho Rousu, Philip D. Butcher, Simon J. Waddell

Suomen molekyylilääketieteen instituutti

Tutkimustuotos: Artikkelijulkaisu › Artikkeli › Tieteellinen › vertaisarvioitu

Alkuperäiskieli	englanti
Artikkeli	68
Lehti	BMC Medicine
Vuosikerta	14
Sivumäärä	13
ISSN	1741-7015
DOI - pysyväislinkit	https://doi.org/10.1186/s12916-016-0609-3
Tila	Julkaistu - 7 huhtik. 2016
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

3111 Biolääketieteet

Pääsy asiakirjaan

10.1186/s12916-016-0609-3

Profiling persistent tubercule bacilliLopullinen julkaistu versio, 2,94 MBLisenssi: CC BY

Siteeraa tätä

Honeyborne, I., McHugh, T. D., Kuittinen, I., Cichonska, A., Evangelopoulos, D., Ronacher, K., van Helden, P. D., Gillespie, S. H., Fernandez-Reyes, D., Walzl, G., Rousu, J., Butcher, P. D., & Waddell, S. J. (2016). Profiling persistent tubercule bacilli from patient sputa during therapy predicts early drug efficacy. BMC Medicine, 14, [68]. https://doi.org/10.1186/s12916-016-0609-3

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title = "Profiling persistent tubercule bacilli from patient sputa during therapy predicts early drug efficacy",

keywords = "Mycobacterium tuberculosis, Sputum, Transcriptional profiling, Predictive biomarker, Persistent infection, GENE-EXPRESSION DATA, MYCOBACTERIUM-TUBERCULOSIS, TRANSCRIPTIONAL ADAPTATION, PULMONARY TUBERCULOSIS, CULTURE CONVERSION, MACROPHAGES, METABOLISM, SELECTION, TIME, POPULATIONS, 3111 Biomedicine",

author = "Isobella Honeyborne and McHugh, {Timothy D.} and Iitu Kuittinen and Anna Cichonska and Dimitrios Evangelopoulos and Katharina Ronacher and {van Helden}, {Paul D.} and Gillespie, {Stephen H.} and Delmiro Fernandez-Reyes and Gerhard Walzl and Juho Rousu and Butcher, {Philip D.} and Waddell, {Simon J.}",

year = "2016",

month = apr,

day = "7",

doi = "10.1186/s12916-016-0609-3",

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T1 - Profiling persistent tubercule bacilli from patient sputa during therapy predicts early drug efficacy

AU - Honeyborne, Isobella

AU - McHugh, Timothy D.

AU - Kuittinen, Iitu

AU - Cichonska, Anna

AU - Evangelopoulos, Dimitrios

AU - Ronacher, Katharina

AU - van Helden, Paul D.

AU - Gillespie, Stephen H.

AU - Fernandez-Reyes, Delmiro

AU - Walzl, Gerhard

AU - Rousu, Juho

AU - Butcher, Philip D.

AU - Waddell, Simon J.

PY - 2016/4/7

Y1 - 2016/4/7

KW - Mycobacterium tuberculosis

KW - Sputum

KW - Transcriptional profiling

KW - Predictive biomarker

KW - Persistent infection

KW - GENE-EXPRESSION DATA

KW - MYCOBACTERIUM-TUBERCULOSIS

KW - TRANSCRIPTIONAL ADAPTATION

KW - PULMONARY TUBERCULOSIS

KW - CULTURE CONVERSION

KW - MACROPHAGES

KW - METABOLISM

KW - SELECTION

KW - TIME

KW - POPULATIONS

KW - 3111 Biomedicine

U2 - 10.1186/s12916-016-0609-3

DO - 10.1186/s12916-016-0609-3

M3 - Article

VL - 14

JO - BMC Medicine

JF - BMC Medicine

SN - 1741-7015

M1 - 68

ER -