Prognostic and diagnostic value of REG4 serum and tissue expression in pancreatic ductal adenocarcinoma

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Kuvaus

Expression of regenerating islet-derived protein 4 (REG4), a secretory protein involved in cell differentiation and proliferation, is upregulated in inflammatory bowel diseases and in many gastrointestinal malignancies. The prognostic significance of its expression in pancreatic ductal adenocarcinoma is unknown. Our aim was to investigate tumor tissue and serum REG4 expression in pancreatic ductal adenocarcinoma patients. We also evaluated as a control the diagnostic value of serum REG4 level in patients with chronic pancreatitis. Immunohistochemical expression of REG4 was evaluated in 154 surgical specimens and serum REG4 level in 130 samples from pancreatic ductal adenocarcinoma patients treated at Helsinki University Hospital, Finland, in 2000–2011. REG4 tissue and serum expression was assessed in relation to clinicopathological parameters and patient survival. A chronic pancreatitis control group comprised 34 patients who underwent pancreatic resection because of suspicion of malignancy. Significant survival differences were detectable in subgroups: in tumor stages IA–IIA, high serum REG4 level predicted worse survival (p=0.046). In patients with grade I tumor, positive tissue REG4 expression predicted better survival (p=0.006). In multivariate analysis, neither tissue nor serum REG4 expression was independent prognostic factors. Serum REG4 levels were higher in pancreatic ductal adenocarcinoma than in chronic pancreatitis (p=0.002), with diagnostic sensitivity of 45% and specificity of 91%. In logistic regression analysis, a multivariate model with REG4, CA19-9, and age provided sensitivity of 82% and specificity of 79%. REG4 tissue expression is a prognostic marker in subgroups of pancreatic ductal adenocarcinoma patients. Serum REG4 level might be useful in differential diagnosis between pancreatic ductal adenocarcinoma and chronic pancreatitis. © 2018, © The Author(s) 2018.
Alkuperäiskielienglanti
LehtiTumor Biology
Vuosikerta40
Numero3
Sivumäärä10
ISSN1010-4283
DOI - pysyväislinkit
TilaJulkaistu - 2018
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

  • 3111 Biolääketieteet
  • 3122 Syöpätaudit

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@article{3a222d240d1745a7911cd6f78d25a227,
title = "Prognostic and diagnostic value of REG4 serum and tissue expression in pancreatic ductal adenocarcinoma",
abstract = "Expression of regenerating islet-derived protein 4 (REG4), a secretory protein involved in cell differentiation and proliferation, is upregulated in inflammatory bowel diseases and in many gastrointestinal malignancies. The prognostic significance of its expression in pancreatic ductal adenocarcinoma is unknown. Our aim was to investigate tumor tissue and serum REG4 expression in pancreatic ductal adenocarcinoma patients. We also evaluated as a control the diagnostic value of serum REG4 level in patients with chronic pancreatitis. Immunohistochemical expression of REG4 was evaluated in 154 surgical specimens and serum REG4 level in 130 samples from pancreatic ductal adenocarcinoma patients treated at Helsinki University Hospital, Finland, in 2000–2011. REG4 tissue and serum expression was assessed in relation to clinicopathological parameters and patient survival. A chronic pancreatitis control group comprised 34 patients who underwent pancreatic resection because of suspicion of malignancy. Significant survival differences were detectable in subgroups: in tumor stages IA–IIA, high serum REG4 level predicted worse survival (p=0.046). In patients with grade I tumor, positive tissue REG4 expression predicted better survival (p=0.006). In multivariate analysis, neither tissue nor serum REG4 expression was independent prognostic factors. Serum REG4 levels were higher in pancreatic ductal adenocarcinoma than in chronic pancreatitis (p=0.002), with diagnostic sensitivity of 45{\%} and specificity of 91{\%}. In logistic regression analysis, a multivariate model with REG4, CA19-9, and age provided sensitivity of 82{\%} and specificity of 79{\%}. REG4 tissue expression is a prognostic marker in subgroups of pancreatic ductal adenocarcinoma patients. Serum REG4 level might be useful in differential diagnosis between pancreatic ductal adenocarcinoma and chronic pancreatitis. {\circledC} 2018, {\circledC} The Author(s) 2018.",
keywords = "pancreatitis associated protein, REG4 protein, human, tumor marker, adult, aged, biosynthesis, blood, chronic pancreatitis, differential diagnosis, female, human, immunohistochemistry, Kaplan Meier method, male, metabolism, middle aged, outcome assessment, pancreas carcinoma, pancreas tumor, procedures, prognosis, proportional hazards model, statistics and numerical data, Adult, Aged, Biomarkers, Tumor, Carcinoma, Pancreatic Ductal, Diagnosis, Differential, Female, Humans, Immunohistochemistry, Kaplan-Meier Estimate, Male, Middle Aged, Outcome Assessment (Health Care), Pancreatic Neoplasms, Pancreatitis, Chronic, Pancreatitis-Associated Proteins, Prognosis, Proportional Hazards Models, 3111 Biomedicine, 3122 Cancers",
author = "K. Saukkonen and J. Hagstr{\"o}m and H. Mustonen and Laura Lehtinen and O. Carpen and L.C. Andersson and H. Sepp{\"a}nen and C. Haglund",
year = "2018",
doi = "10.1177/1010428318761494",
language = "English",
volume = "40",
journal = "Tumor Biology",
issn = "1010-4283",
publisher = "SAGE Publications Ltd STM",
number = "3",

}

Prognostic and diagnostic value of REG4 serum and tissue expression in pancreatic ductal adenocarcinoma. / Saukkonen, K.; Hagström, J.; Mustonen, H.; Lehtinen, Laura; Carpen, O.; Andersson, L.C.; Seppänen, H.; Haglund, C.

julkaisussa: Tumor Biology, Vuosikerta 40, Nro 3, 2018.

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

TY - JOUR

T1 - Prognostic and diagnostic value of REG4 serum and tissue expression in pancreatic ductal adenocarcinoma

AU - Saukkonen, K.

AU - Hagström, J.

AU - Mustonen, H.

AU - Lehtinen, Laura

AU - Carpen, O.

AU - Andersson, L.C.

AU - Seppänen, H.

AU - Haglund, C.

PY - 2018

Y1 - 2018

N2 - Expression of regenerating islet-derived protein 4 (REG4), a secretory protein involved in cell differentiation and proliferation, is upregulated in inflammatory bowel diseases and in many gastrointestinal malignancies. The prognostic significance of its expression in pancreatic ductal adenocarcinoma is unknown. Our aim was to investigate tumor tissue and serum REG4 expression in pancreatic ductal adenocarcinoma patients. We also evaluated as a control the diagnostic value of serum REG4 level in patients with chronic pancreatitis. Immunohistochemical expression of REG4 was evaluated in 154 surgical specimens and serum REG4 level in 130 samples from pancreatic ductal adenocarcinoma patients treated at Helsinki University Hospital, Finland, in 2000–2011. REG4 tissue and serum expression was assessed in relation to clinicopathological parameters and patient survival. A chronic pancreatitis control group comprised 34 patients who underwent pancreatic resection because of suspicion of malignancy. Significant survival differences were detectable in subgroups: in tumor stages IA–IIA, high serum REG4 level predicted worse survival (p=0.046). In patients with grade I tumor, positive tissue REG4 expression predicted better survival (p=0.006). In multivariate analysis, neither tissue nor serum REG4 expression was independent prognostic factors. Serum REG4 levels were higher in pancreatic ductal adenocarcinoma than in chronic pancreatitis (p=0.002), with diagnostic sensitivity of 45% and specificity of 91%. In logistic regression analysis, a multivariate model with REG4, CA19-9, and age provided sensitivity of 82% and specificity of 79%. REG4 tissue expression is a prognostic marker in subgroups of pancreatic ductal adenocarcinoma patients. Serum REG4 level might be useful in differential diagnosis between pancreatic ductal adenocarcinoma and chronic pancreatitis. © 2018, © The Author(s) 2018.

AB - Expression of regenerating islet-derived protein 4 (REG4), a secretory protein involved in cell differentiation and proliferation, is upregulated in inflammatory bowel diseases and in many gastrointestinal malignancies. The prognostic significance of its expression in pancreatic ductal adenocarcinoma is unknown. Our aim was to investigate tumor tissue and serum REG4 expression in pancreatic ductal adenocarcinoma patients. We also evaluated as a control the diagnostic value of serum REG4 level in patients with chronic pancreatitis. Immunohistochemical expression of REG4 was evaluated in 154 surgical specimens and serum REG4 level in 130 samples from pancreatic ductal adenocarcinoma patients treated at Helsinki University Hospital, Finland, in 2000–2011. REG4 tissue and serum expression was assessed in relation to clinicopathological parameters and patient survival. A chronic pancreatitis control group comprised 34 patients who underwent pancreatic resection because of suspicion of malignancy. Significant survival differences were detectable in subgroups: in tumor stages IA–IIA, high serum REG4 level predicted worse survival (p=0.046). In patients with grade I tumor, positive tissue REG4 expression predicted better survival (p=0.006). In multivariate analysis, neither tissue nor serum REG4 expression was independent prognostic factors. Serum REG4 levels were higher in pancreatic ductal adenocarcinoma than in chronic pancreatitis (p=0.002), with diagnostic sensitivity of 45% and specificity of 91%. In logistic regression analysis, a multivariate model with REG4, CA19-9, and age provided sensitivity of 82% and specificity of 79%. REG4 tissue expression is a prognostic marker in subgroups of pancreatic ductal adenocarcinoma patients. Serum REG4 level might be useful in differential diagnosis between pancreatic ductal adenocarcinoma and chronic pancreatitis. © 2018, © The Author(s) 2018.

KW - pancreatitis associated protein

KW - REG4 protein, human

KW - tumor marker, adult

KW - aged

KW - biosynthesis

KW - blood

KW - chronic pancreatitis

KW - differential diagnosis

KW - female

KW - human

KW - immunohistochemistry

KW - Kaplan Meier method

KW - male

KW - metabolism

KW - middle aged

KW - outcome assessment

KW - pancreas carcinoma

KW - pancreas tumor

KW - procedures

KW - prognosis

KW - proportional hazards model

KW - statistics and numerical data, Adult

KW - Aged

KW - Biomarkers, Tumor

KW - Carcinoma, Pancreatic Ductal

KW - Diagnosis, Differential

KW - Female

KW - Humans

KW - Immunohistochemistry

KW - Kaplan-Meier Estimate

KW - Male

KW - Middle Aged

KW - Outcome Assessment (Health Care)

KW - Pancreatic Neoplasms

KW - Pancreatitis, Chronic

KW - Pancreatitis-Associated Proteins

KW - Prognosis

KW - Proportional Hazards Models

KW - 3111 Biomedicine

KW - 3122 Cancers

U2 - 10.1177/1010428318761494

DO - 10.1177/1010428318761494

M3 - Article

VL - 40

JO - Tumor Biology

JF - Tumor Biology

SN - 1010-4283

IS - 3

ER -