Quercetin-Based Modified Porous Silicon Nanoparticles for Enhanced Inhibition of Doxorubicin-Resistant Cancer Cells

Zehua Liu, Vimalkumar Balasubramanian, Chinmaya Bhat, Mikko Vahermo, Ermei Mäkilä, Marianna Kemell, Flavia Fontana, Agnė Janoniene, Vilma Petrikaite, Jarno Salonen, Jari Yli-Kauhaluoma, Jouni Hirvonen, Hongbo Zhang, Helder A. Santos

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Kuvaus

One of the most challenging obstacle in nanoparticle’s surface modification is to achieve the concept that one ligand can accomplish multiple purposes. Upon such consideration, 3-aminopropoxy-linked quercetin (AmQu), a derivative of a natural flavonoid inspired by the structure of dopamine, is designed and subsequently used to modify the surface of thermally hydrocarbonized porous silicon (PSi) nanoparticles. This nanosystem inherits several advanced properties in a single carrier, including promoted anticancer efficiency, multiple drug resistance (MDR) reversing, stimuli-responsive drug release, drug release monitoring, and enhanced particle-cell interactions. The anti-cancer drug doxorubicin (DOX) is efficiently loaded into this nanosystem and released in a pH-dependent manner. AmQu also effectively quenches the fluorescence of the loaded DOX, thereby allowing the use of the nanosystem for monitoring the intracellular drug release. Furthermore, a synergistic effect with the presence of AmQu is observed in both normal MCF-7 and DOX-resistant MCF-7 breast cancer cells. Due to the similar structure as dopamine, AmQu may facilitate both the interaction and internalization of PSi into the cells. Overall, this PSi-based platform exhibits remarkable superiority in both multi-functionality and anti-cancer efficiency, making this nanovector a promising system for anti-MDR cancer treatment.
Alkuperäiskielienglanti
Artikkeli1601009
LehtiAdvanced Healthcare Materials
Vuosikerta6
Numero3
Sivumäärä11
ISSN2192-2640
DOI - pysyväislinkit
TilaJulkaistu - 8 helmikuuta 2017
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

  • 216 Materiaalitekniikka
  • 221 Nanoteknologia
  • 317 Farmasia

Lainaa tätä

@article{36a55c96cfdd4aacafcb6303be6cb657,
title = "Quercetin-Based Modified Porous Silicon Nanoparticles for Enhanced Inhibition of Doxorubicin-Resistant Cancer Cells",
abstract = "One of the most challenging obstacle in nanoparticle’s surface modification is to achieve the concept that one ligand can accomplish multiple purposes. Upon such consideration, 3-aminopropoxy-linked quercetin (AmQu), a derivative of a natural flavonoid inspired by the structure of dopamine, is designed and subsequently used to modify the surface of thermally hydrocarbonized porous silicon (PSi) nanoparticles. This nanosystem inherits several advanced properties in a single carrier, including promoted anticancer efficiency, multiple drug resistance (MDR) reversing, stimuli-responsive drug release, drug release monitoring, and enhanced particle-cell interactions. The anti-cancer drug doxorubicin (DOX) is efficiently loaded into this nanosystem and released in a pH-dependent manner. AmQu also effectively quenches the fluorescence of the loaded DOX, thereby allowing the use of the nanosystem for monitoring the intracellular drug release. Furthermore, a synergistic effect with the presence of AmQu is observed in both normal MCF-7 and DOX-resistant MCF-7 breast cancer cells. Due to the similar structure as dopamine, AmQu may facilitate both the interaction and internalization of PSi into the cells. Overall, this PSi-based platform exhibits remarkable superiority in both multi-functionality and anti-cancer efficiency, making this nanovector a promising system for anti-MDR cancer treatment.",
keywords = "216 Materials engineering, 221 Nano-technology, 317 Pharmacy, MUSSEL-INSPIRED POLYDOPAMINE , MULTIDRUG-RESISTANCE , SURFACE MODIFICATION , ANTICANCER DRUGS , DELIVERY , ADHESION , IMMOBILIZATION , BIOSENSOR , COATINGS , RELEASE",
author = "Zehua Liu and Vimalkumar Balasubramanian and Chinmaya Bhat and Mikko Vahermo and Ermei M{\"a}kil{\"a} and Marianna Kemell and Flavia Fontana and Agnė Janoniene and Vilma Petrikaite and Jarno Salonen and Jari Yli-Kauhaluoma and Jouni Hirvonen and Hongbo Zhang and {A. Santos}, Helder",
year = "2017",
month = "2",
day = "8",
doi = "10.1002/adhm.201601009",
language = "English",
volume = "6",
journal = "Advanced Healthcare Materials",
issn = "2192-2640",
publisher = "Wiley",
number = "3",

}

Quercetin-Based Modified Porous Silicon Nanoparticles for Enhanced Inhibition of Doxorubicin-Resistant Cancer Cells. / Liu, Zehua; Balasubramanian, Vimalkumar; Bhat, Chinmaya; Vahermo, Mikko ; Mäkilä, Ermei; Kemell, Marianna ; Fontana, Flavia; Janoniene, Agnė; Petrikaite, Vilma; Salonen, Jarno; Yli-Kauhaluoma, Jari ; Hirvonen, Jouni ; Zhang, Hongbo; A. Santos, Helder.

julkaisussa: Advanced Healthcare Materials, Vuosikerta 6, Nro 3, 1601009, 08.02.2017.

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

TY - JOUR

T1 - Quercetin-Based Modified Porous Silicon Nanoparticles for Enhanced Inhibition of Doxorubicin-Resistant Cancer Cells

AU - Liu, Zehua

AU - Balasubramanian, Vimalkumar

AU - Bhat, Chinmaya

AU - Vahermo, Mikko

AU - Mäkilä, Ermei

AU - Kemell, Marianna

AU - Fontana, Flavia

AU - Janoniene, Agnė

AU - Petrikaite, Vilma

AU - Salonen, Jarno

AU - Yli-Kauhaluoma, Jari

AU - Hirvonen, Jouni

AU - Zhang, Hongbo

AU - A. Santos, Helder

PY - 2017/2/8

Y1 - 2017/2/8

N2 - One of the most challenging obstacle in nanoparticle’s surface modification is to achieve the concept that one ligand can accomplish multiple purposes. Upon such consideration, 3-aminopropoxy-linked quercetin (AmQu), a derivative of a natural flavonoid inspired by the structure of dopamine, is designed and subsequently used to modify the surface of thermally hydrocarbonized porous silicon (PSi) nanoparticles. This nanosystem inherits several advanced properties in a single carrier, including promoted anticancer efficiency, multiple drug resistance (MDR) reversing, stimuli-responsive drug release, drug release monitoring, and enhanced particle-cell interactions. The anti-cancer drug doxorubicin (DOX) is efficiently loaded into this nanosystem and released in a pH-dependent manner. AmQu also effectively quenches the fluorescence of the loaded DOX, thereby allowing the use of the nanosystem for monitoring the intracellular drug release. Furthermore, a synergistic effect with the presence of AmQu is observed in both normal MCF-7 and DOX-resistant MCF-7 breast cancer cells. Due to the similar structure as dopamine, AmQu may facilitate both the interaction and internalization of PSi into the cells. Overall, this PSi-based platform exhibits remarkable superiority in both multi-functionality and anti-cancer efficiency, making this nanovector a promising system for anti-MDR cancer treatment.

AB - One of the most challenging obstacle in nanoparticle’s surface modification is to achieve the concept that one ligand can accomplish multiple purposes. Upon such consideration, 3-aminopropoxy-linked quercetin (AmQu), a derivative of a natural flavonoid inspired by the structure of dopamine, is designed and subsequently used to modify the surface of thermally hydrocarbonized porous silicon (PSi) nanoparticles. This nanosystem inherits several advanced properties in a single carrier, including promoted anticancer efficiency, multiple drug resistance (MDR) reversing, stimuli-responsive drug release, drug release monitoring, and enhanced particle-cell interactions. The anti-cancer drug doxorubicin (DOX) is efficiently loaded into this nanosystem and released in a pH-dependent manner. AmQu also effectively quenches the fluorescence of the loaded DOX, thereby allowing the use of the nanosystem for monitoring the intracellular drug release. Furthermore, a synergistic effect with the presence of AmQu is observed in both normal MCF-7 and DOX-resistant MCF-7 breast cancer cells. Due to the similar structure as dopamine, AmQu may facilitate both the interaction and internalization of PSi into the cells. Overall, this PSi-based platform exhibits remarkable superiority in both multi-functionality and anti-cancer efficiency, making this nanovector a promising system for anti-MDR cancer treatment.

KW - 216 Materials engineering

KW - 221 Nano-technology

KW - 317 Pharmacy

KW - MUSSEL-INSPIRED POLYDOPAMINE

KW - MULTIDRUG-RESISTANCE

KW - SURFACE MODIFICATION

KW - ANTICANCER DRUGS

KW - DELIVERY

KW - ADHESION

KW - IMMOBILIZATION

KW - BIOSENSOR

KW - COATINGS

KW - RELEASE

UR - http://onlinelibrary.wiley.com/journal/10.1002/%28ISSN%292192-2659

U2 - 10.1002/adhm.201601009

DO - 10.1002/adhm.201601009

M3 - Article

VL - 6

JO - Advanced Healthcare Materials

JF - Advanced Healthcare Materials

SN - 2192-2640

IS - 3

M1 - 1601009

ER -