Kuvaus

Background: Increased incidence of bacterial pneumonia (BP) has been reported in Irish Wolfhounds (IWHs), and recurrence of BP is common. The etiology of recurrent pneumonia in IWHs is largely unknown.

Objectives: To describe clinical findings in IWHs with recurrent BP and investigate possible etiologies.

Animals: Eleven affected IWHs, 25 healthy IWHs, 28 healthy dogs of other Sighthound breeds, and 16 healthy dogs of other breeds.

Methods: Prospective cross-sectional observational study. All affected IWHs underwent thorough clinical examinations including thoracic radiographs, thoracic computed tomography, electron microscopic evaluation of ciliary structure, and bronchoscopy and bronchoalveolar lavage fluid (BALF) cytology and culture. Serum and BALF immunoglobulin concentrations were measured using an ELISA method, and peripheral blood lymphocyte subpopulations were analyzed using flow cytometry. Esophageal function was assessed by fluoroscopy (n = 2).

Results: Median age of onset was 5.0 years (range, 0.4-6.5 years), and when presented for study, dogs had experienced a median of 5 previous episodes of BP (range, 2-6). The following predisposing factors to BP were detected: focal bronchiectasis (10/11), unilateral (2/9) and bilateral (1/9) laryngeal paralysis, and esophageal hypomotility (2/2). Local or systemic immunoglobulin deficiencies or primary ciliary defects were not detected.

Conclusions and Clinical Importance: Recurrent BP affects mostly middle-aged and older IWHs without any evident immune deficit or primary ciliary defects. Focal BE was a frequent finding in affected dogs and likely contributed to the development of recurrent respiratory infections. Laryngeal and esophageal dysfunction identified in a minority of dogs may contribute to recurrent BP.

Alkuperäiskielienglanti
LehtiJournal of Veterinary Internal Medicine
Vuosikerta33
Numero2
Sivut846-855
Sivumäärä10
ISSN1939-1676
DOI - pysyväislinkit
TilaJulkaistu - maaliskuuta 2019
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

  • 413 Eläinlääketiede

Lainaa tätä

@article{d1156f9a9428481190d2af34b09c25ad,
title = "Recurrent bacterial pneumonia in Irish Wolfhounds: Clinical findings and etiological studies",
abstract = "Background: Increased incidence of bacterial pneumonia (BP) has been reported in Irish Wolfhounds (IWHs), and recurrence of BP is common. The etiology of recurrent pneumonia in IWHs is largely unknown.Objectives: To describe clinical findings in IWHs with recurrent BP and investigate possible etiologies.Animals: Eleven affected IWHs, 25 healthy IWHs, 28 healthy dogs of other Sighthound breeds, and 16 healthy dogs of other breeds.Methods: Prospective cross-sectional observational study. All affected IWHs underwent thorough clinical examinations including thoracic radiographs, thoracic computed tomography, electron microscopic evaluation of ciliary structure, and bronchoscopy and bronchoalveolar lavage fluid (BALF) cytology and culture. Serum and BALF immunoglobulin concentrations were measured using an ELISA method, and peripheral blood lymphocyte subpopulations were analyzed using flow cytometry. Esophageal function was assessed by fluoroscopy (n = 2).Results: Median age of onset was 5.0 years (range, 0.4-6.5 years), and when presented for study, dogs had experienced a median of 5 previous episodes of BP (range, 2-6). The following predisposing factors to BP were detected: focal bronchiectasis (10/11), unilateral (2/9) and bilateral (1/9) laryngeal paralysis, and esophageal hypomotility (2/2). Local or systemic immunoglobulin deficiencies or primary ciliary defects were not detected.Conclusions and Clinical Importance: Recurrent BP affects mostly middle-aged and older IWHs without any evident immune deficit or primary ciliary defects. Focal BE was a frequent finding in affected dogs and likely contributed to the development of recurrent respiratory infections. Laryngeal and esophageal dysfunction identified in a minority of dogs may contribute to recurrent BP.",
keywords = "canine, dog, pulmonary, respiratory infection, PRIMARY CILIARY DYSKINESIA, ASPIRATION PNEUMONIA, RISK-FACTORS, DOGS, PREVALENCE, DEFICIENCY, SERUM, SIZE, BRONCHIECTASIS, COMPLICATIONS, 413 Veterinary science",
author = "Viitanen, {Sanna Johanna} and Lappalainen, {Anu Katriina} and Koho, {Ninna Maaria} and Pessa-Morikawa, {Tiina Inkeri} and Lorenzo Ressel and Minna Rajam{\"a}ki",
year = "2019",
month = "3",
doi = "10.1111/jvim.15413",
language = "English",
volume = "33",
pages = "846--855",
journal = "Journal of Veterinary Internal Medicine",
issn = "0891-6640",
publisher = "Wiley",
number = "2",

}

TY - JOUR

T1 - Recurrent bacterial pneumonia in Irish Wolfhounds: Clinical findings and etiological studies

AU - Viitanen, Sanna Johanna

AU - Lappalainen, Anu Katriina

AU - Koho, Ninna Maaria

AU - Pessa-Morikawa, Tiina Inkeri

AU - Ressel, Lorenzo

AU - Rajamäki, Minna

PY - 2019/3

Y1 - 2019/3

N2 - Background: Increased incidence of bacterial pneumonia (BP) has been reported in Irish Wolfhounds (IWHs), and recurrence of BP is common. The etiology of recurrent pneumonia in IWHs is largely unknown.Objectives: To describe clinical findings in IWHs with recurrent BP and investigate possible etiologies.Animals: Eleven affected IWHs, 25 healthy IWHs, 28 healthy dogs of other Sighthound breeds, and 16 healthy dogs of other breeds.Methods: Prospective cross-sectional observational study. All affected IWHs underwent thorough clinical examinations including thoracic radiographs, thoracic computed tomography, electron microscopic evaluation of ciliary structure, and bronchoscopy and bronchoalveolar lavage fluid (BALF) cytology and culture. Serum and BALF immunoglobulin concentrations were measured using an ELISA method, and peripheral blood lymphocyte subpopulations were analyzed using flow cytometry. Esophageal function was assessed by fluoroscopy (n = 2).Results: Median age of onset was 5.0 years (range, 0.4-6.5 years), and when presented for study, dogs had experienced a median of 5 previous episodes of BP (range, 2-6). The following predisposing factors to BP were detected: focal bronchiectasis (10/11), unilateral (2/9) and bilateral (1/9) laryngeal paralysis, and esophageal hypomotility (2/2). Local or systemic immunoglobulin deficiencies or primary ciliary defects were not detected.Conclusions and Clinical Importance: Recurrent BP affects mostly middle-aged and older IWHs without any evident immune deficit or primary ciliary defects. Focal BE was a frequent finding in affected dogs and likely contributed to the development of recurrent respiratory infections. Laryngeal and esophageal dysfunction identified in a minority of dogs may contribute to recurrent BP.

AB - Background: Increased incidence of bacterial pneumonia (BP) has been reported in Irish Wolfhounds (IWHs), and recurrence of BP is common. The etiology of recurrent pneumonia in IWHs is largely unknown.Objectives: To describe clinical findings in IWHs with recurrent BP and investigate possible etiologies.Animals: Eleven affected IWHs, 25 healthy IWHs, 28 healthy dogs of other Sighthound breeds, and 16 healthy dogs of other breeds.Methods: Prospective cross-sectional observational study. All affected IWHs underwent thorough clinical examinations including thoracic radiographs, thoracic computed tomography, electron microscopic evaluation of ciliary structure, and bronchoscopy and bronchoalveolar lavage fluid (BALF) cytology and culture. Serum and BALF immunoglobulin concentrations were measured using an ELISA method, and peripheral blood lymphocyte subpopulations were analyzed using flow cytometry. Esophageal function was assessed by fluoroscopy (n = 2).Results: Median age of onset was 5.0 years (range, 0.4-6.5 years), and when presented for study, dogs had experienced a median of 5 previous episodes of BP (range, 2-6). The following predisposing factors to BP were detected: focal bronchiectasis (10/11), unilateral (2/9) and bilateral (1/9) laryngeal paralysis, and esophageal hypomotility (2/2). Local or systemic immunoglobulin deficiencies or primary ciliary defects were not detected.Conclusions and Clinical Importance: Recurrent BP affects mostly middle-aged and older IWHs without any evident immune deficit or primary ciliary defects. Focal BE was a frequent finding in affected dogs and likely contributed to the development of recurrent respiratory infections. Laryngeal and esophageal dysfunction identified in a minority of dogs may contribute to recurrent BP.

KW - canine

KW - dog

KW - pulmonary

KW - respiratory infection

KW - PRIMARY CILIARY DYSKINESIA

KW - ASPIRATION PNEUMONIA

KW - RISK-FACTORS

KW - DOGS

KW - PREVALENCE

KW - DEFICIENCY

KW - SERUM

KW - SIZE

KW - BRONCHIECTASIS

KW - COMPLICATIONS

KW - 413 Veterinary science

U2 - 10.1111/jvim.15413

DO - 10.1111/jvim.15413

M3 - Article

VL - 33

SP - 846

EP - 855

JO - Journal of Veterinary Internal Medicine

JF - Journal of Veterinary Internal Medicine

SN - 0891-6640

IS - 2

ER -