Risk of anal furunculosis in German Shepherd dogs is associated with the major histocompatibility complex

L. J Kennedy, T O'Neill, A House, A Barnes, Kaisa Kyöstilä, J Innes, N Fretwell, M. J Day, B Catchpole, Hannes Lohi, William E Ollier

    Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

    Kuvaus

    "Anal furunculosis (AF) is a chronic, progressive inflammatory disease of the perianal tissues most frequently affecting middle-aged or older German Shepherd dogs (GSD). Because this breed accounts for over 80% of all reported cases, there is likely to be a genetic association with disease susceptibility. Although there are some similarities with perianal fistulation that occurs in human Crohn's disease, the aetiology and pathogenesis of AF are still poorly understood. Recent research has suggested an immune-mediated aetiology, and evidence for this has been further provided by clinical responses to the immunosuppressive drug cyclosporin. The aim of the current study was to investigate canine major histocompatibility complex immune response genes. Dog leucocyte antigen class II alleles and haplotypes were characterised by sequence-based typing of 107 GSD affected with AF and 196 breed-matched controls collected in the UK. A highly significant association of DLA-DRB1*00101 with the presence of AF was observed (OR = 5.01, CI = 2.7-9.3, P < 0.00000001). This association was confirmed in a second cohort of GSD collected in Finland. Homozygosity for this allele is associated with an earlier disease onset."
    Alkuperäiskielienglanti
    LehtiTissue Antigens
    Vuosikerta71
    Numero1
    Sivut51-56
    Sivumäärä6
    ISSN0001-2815
    DOI - pysyväislinkit
    TilaJulkaistu - 2008
    OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

    Lainaa tätä

    Kennedy, L. J ; O'Neill, T ; House, A ; Barnes, A ; Kyöstilä, Kaisa ; Innes, J ; Fretwell, N ; Day, M. J ; Catchpole, B ; Lohi, Hannes ; Ollier, William E. / Risk of anal furunculosis in German Shepherd dogs is associated with the major histocompatibility complex. Julkaisussa: Tissue Antigens. 2008 ; Vuosikerta 71, Nro 1. Sivut 51-56.
    @article{5b138af7a0da44888a001603c6c9f617,
    title = "Risk of anal furunculosis in German Shepherd dogs is associated with the major histocompatibility complex",
    abstract = "{"}Anal furunculosis (AF) is a chronic, progressive inflammatory disease of the perianal tissues most frequently affecting middle-aged or older German Shepherd dogs (GSD). Because this breed accounts for over 80{\%} of all reported cases, there is likely to be a genetic association with disease susceptibility. Although there are some similarities with perianal fistulation that occurs in human Crohn's disease, the aetiology and pathogenesis of AF are still poorly understood. Recent research has suggested an immune-mediated aetiology, and evidence for this has been further provided by clinical responses to the immunosuppressive drug cyclosporin. The aim of the current study was to investigate canine major histocompatibility complex immune response genes. Dog leucocyte antigen class II alleles and haplotypes were characterised by sequence-based typing of 107 GSD affected with AF and 196 breed-matched controls collected in the UK. A highly significant association of DLA-DRB1*00101 with the presence of AF was observed (OR = 5.01, CI = 2.7-9.3, P < 0.00000001). This association was confirmed in a second cohort of GSD collected in Finland. Homozygosity for this allele is associated with an earlier disease onset.{"}",
    author = "Kennedy, {L. J} and T O'Neill and A House and A Barnes and Kaisa Ky{\"o}stil{\"a} and J Innes and N Fretwell and Day, {M. J} and B Catchpole and Hannes Lohi and Ollier, {William E}",
    year = "2008",
    doi = "10.1111/j.1399-0039.2007.00964.x",
    language = "English",
    volume = "71",
    pages = "51--56",
    journal = "Tissue Antigens",
    issn = "0001-2815",
    publisher = "WILEY-BLACKWELL MUNKSGAARD",
    number = "1",

    }

    Kennedy, LJ, O'Neill, T, House, A, Barnes, A, Kyöstilä, K, Innes, J, Fretwell, N, Day, MJ, Catchpole, B, Lohi, H & Ollier, WE 2008, 'Risk of anal furunculosis in German Shepherd dogs is associated with the major histocompatibility complex' Tissue Antigens, Vuosikerta 71, Nro 1, Sivut 51-56. https://doi.org/10.1111/j.1399-0039.2007.00964.x

    Risk of anal furunculosis in German Shepherd dogs is associated with the major histocompatibility complex. / Kennedy, L. J; O'Neill, T; House, A; Barnes, A; Kyöstilä, Kaisa; Innes, J; Fretwell, N; Day, M. J; Catchpole, B; Lohi, Hannes; Ollier, William E.

    julkaisussa: Tissue Antigens, Vuosikerta 71, Nro 1, 2008, s. 51-56.

    Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

    TY - JOUR

    T1 - Risk of anal furunculosis in German Shepherd dogs is associated with the major histocompatibility complex

    AU - Kennedy, L. J

    AU - O'Neill, T

    AU - House, A

    AU - Barnes, A

    AU - Kyöstilä, Kaisa

    AU - Innes, J

    AU - Fretwell, N

    AU - Day, M. J

    AU - Catchpole, B

    AU - Lohi, Hannes

    AU - Ollier, William E

    PY - 2008

    Y1 - 2008

    N2 - "Anal furunculosis (AF) is a chronic, progressive inflammatory disease of the perianal tissues most frequently affecting middle-aged or older German Shepherd dogs (GSD). Because this breed accounts for over 80% of all reported cases, there is likely to be a genetic association with disease susceptibility. Although there are some similarities with perianal fistulation that occurs in human Crohn's disease, the aetiology and pathogenesis of AF are still poorly understood. Recent research has suggested an immune-mediated aetiology, and evidence for this has been further provided by clinical responses to the immunosuppressive drug cyclosporin. The aim of the current study was to investigate canine major histocompatibility complex immune response genes. Dog leucocyte antigen class II alleles and haplotypes were characterised by sequence-based typing of 107 GSD affected with AF and 196 breed-matched controls collected in the UK. A highly significant association of DLA-DRB1*00101 with the presence of AF was observed (OR = 5.01, CI = 2.7-9.3, P < 0.00000001). This association was confirmed in a second cohort of GSD collected in Finland. Homozygosity for this allele is associated with an earlier disease onset."

    AB - "Anal furunculosis (AF) is a chronic, progressive inflammatory disease of the perianal tissues most frequently affecting middle-aged or older German Shepherd dogs (GSD). Because this breed accounts for over 80% of all reported cases, there is likely to be a genetic association with disease susceptibility. Although there are some similarities with perianal fistulation that occurs in human Crohn's disease, the aetiology and pathogenesis of AF are still poorly understood. Recent research has suggested an immune-mediated aetiology, and evidence for this has been further provided by clinical responses to the immunosuppressive drug cyclosporin. The aim of the current study was to investigate canine major histocompatibility complex immune response genes. Dog leucocyte antigen class II alleles and haplotypes were characterised by sequence-based typing of 107 GSD affected with AF and 196 breed-matched controls collected in the UK. A highly significant association of DLA-DRB1*00101 with the presence of AF was observed (OR = 5.01, CI = 2.7-9.3, P < 0.00000001). This association was confirmed in a second cohort of GSD collected in Finland. Homozygosity for this allele is associated with an earlier disease onset."

    U2 - 10.1111/j.1399-0039.2007.00964.x

    DO - 10.1111/j.1399-0039.2007.00964.x

    M3 - Article

    VL - 71

    SP - 51

    EP - 56

    JO - Tissue Antigens

    JF - Tissue Antigens

    SN - 0001-2815

    IS - 1

    ER -