Signal peptide mimicry primes Sec61 for client-selective inhibition

Shahid Rehan; Dale Tranter; Phillip P. P. Sharp; Gregory B. B. Craven; Eric Lowe; Janet L. L. Anderl; Tony Muchamuel; Vahid Abrishami; Suvi Kuivanen; Nicole A. A. Wenzell; Andy Jennings; Chakrapani Kalyanaraman; Tomas Strandin; Matti Javanainen; Olli Vapalahti; Matthew P. P. Jacobson; Dustin McMinn; Christopher J. Kirk; Juha T. Huiskonen; Jack Taunton; Ville O. Paavilainen

doi:10.1038/s41589-023-01326-1

Signal peptide mimicry primes Sec61 for client-selective inhibition

Shahid Rehan, Dale Tranter, Phillip P. P. Sharp, Gregory B. B. Craven, Eric Lowe, Janet L. L. Anderl, Tony Muchamuel, Vahid Abrishami, Suvi Kuivanen, Nicole A. A. Wenzell, Andy Jennings, Chakrapani Kalyanaraman, Tomas Strandin, Matti Javanainen, Olli Vapalahti, Matthew P. P. Jacobson, Dustin McMinn, Christopher J. Kirk, Juha T. Huiskonen, Jack TauntonVille O. Paavilainen

Tutkimustuotos: Artikkelijulkaisu › Artikkeli › Tieteellinen › vertaisarvioitu

Alkuperäiskieli	englanti
Lehti	Nature Chemical Biology
Vuosikerta	19
Sivut	1054–1062
Sivumäärä	27
ISSN	1552-4450
DOI - pysyväislinkit	https://doi.org/10.1038/s41589-023-01326-1
Tila	Julkaistu - 2023
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

Passive membrane-permeability
Linear constraint solver
General force-field
Particle mesh ewald
Endoplasmic-reticulum
Protein translocation
Cotranslational translocation
Microsomal-membranes
Lipid-composition
Structural basis
1182 Biokemia, solu- ja molekyylibiologia

Pääsy asiakirjaan

10.1038/s41589-023-01326-1

s41589-023-01326-1Lopullinen julkaistu versio, 9,15 MBLisenssi: CC BY

Siteeraa tätä

Rehan, S., Tranter, D., Sharp, P. P. P., Craven, G. B. B., Lowe, E., Anderl, J. L. L., Muchamuel, T., Abrishami, V., Kuivanen, S., Wenzell, N. A. A., Jennings, A., Kalyanaraman, C., Strandin, T., Javanainen, M., Vapalahti, O., Jacobson, M. P. P., McMinn, D., Kirk, C. J., Huiskonen, J. T., ... Paavilainen, V. O. (2023). Signal peptide mimicry primes Sec61 for client-selective inhibition. Nature Chemical Biology, 19, 1054–1062. https://doi.org/10.1038/s41589-023-01326-1

@article{0d54c709ea8d423a8c3067022f4ac6b1,

title = "Signal peptide mimicry primes Sec61 for client-selective inhibition",

keywords = "Passive membrane-permeability, Linear constraint solver, General force-field, Particle mesh ewald, Endoplasmic-reticulum, Protein translocation, Cotranslational translocation, Microsomal-membranes, Lipid-composition, Structural basis, 1182 Biochemistry, cell and molecular biology",

author = "Shahid Rehan and Dale Tranter and Sharp, {Phillip P. P.} and Craven, {Gregory B. B.} and Eric Lowe and Anderl, {Janet L. L.} and Tony Muchamuel and Vahid Abrishami and Suvi Kuivanen and Wenzell, {Nicole A. A.} and Andy Jennings and Chakrapani Kalyanaraman and Tomas Strandin and Matti Javanainen and Olli Vapalahti and Jacobson, {Matthew P. P.} and Dustin McMinn and Kirk, {Christopher J.} and Huiskonen, {Juha T.} and Jack Taunton and Paavilainen, {Ville O.}",

year = "2023",

doi = "10.1038/s41589-023-01326-1",

language = "English",

volume = "19",

pages = "1054–1062",

journal = "Nature Chemical Biology",

issn = "1552-4450",

publisher = "Nature Publishing Group",

}

Rehan, S, Tranter, D, Sharp, PPP, Craven, GBB, Lowe, E, Anderl, JLL, Muchamuel, T, Abrishami, V, Kuivanen, S, Wenzell, NAA, Jennings, A, Kalyanaraman, C, Strandin, T, Javanainen, M, Vapalahti, O, Jacobson, MPP, McMinn, D, Kirk, CJ, Huiskonen, JT, Taunton, J & Paavilainen, VO 2023, 'Signal peptide mimicry primes Sec61 for client-selective inhibition', Nature Chemical Biology, Vuosikerta 19, Sivut 1054–1062. https://doi.org/10.1038/s41589-023-01326-1

TY - JOUR

T1 - Signal peptide mimicry primes Sec61 for client-selective inhibition

AU - Rehan, Shahid

AU - Tranter, Dale

AU - Sharp, Phillip P. P.

AU - Craven, Gregory B. B.

AU - Lowe, Eric

AU - Anderl, Janet L. L.

AU - Muchamuel, Tony

AU - Abrishami, Vahid

AU - Kuivanen, Suvi

AU - Wenzell, Nicole A. A.

AU - Jennings, Andy

AU - Kalyanaraman, Chakrapani

AU - Strandin, Tomas

AU - Javanainen, Matti

AU - Vapalahti, Olli

AU - Jacobson, Matthew P. P.

AU - McMinn, Dustin

AU - Kirk, Christopher J.

AU - Huiskonen, Juha T.

AU - Taunton, Jack

AU - Paavilainen, Ville O.

PY - 2023

Y1 - 2023

KW - Passive membrane-permeability

KW - Linear constraint solver

KW - General force-field

KW - Particle mesh ewald

KW - Endoplasmic-reticulum

KW - Protein translocation

KW - Cotranslational translocation

KW - Microsomal-membranes

KW - Lipid-composition

KW - Structural basis

KW - 1182 Biochemistry, cell and molecular biology

U2 - 10.1038/s41589-023-01326-1

DO - 10.1038/s41589-023-01326-1

M3 - Article

C2 - 37169961

SN - 1552-4450

VL - 19

SP - 1054

EP - 1062

JO - Nature Chemical Biology

JF - Nature Chemical Biology

ER -