Stimulation and Inhibition of Lymphangiogenesis Via Adeno-Associated Viral Gene Delivery

Tutkimustuotos: Artikkeli kirjassa/raportissa/konferenssijulkaisussaKirjan luku tai artikkeliTieteellinenvertaisarvioitu

Kuvaus

The lymphatic vessels can be selectively stimulated to grow in adult mice, rats and pigs by application of viral vectors expressing the lymphangiogenic factors VEGF-C or VEGF-D. Vice versa, lymphangiogenesis in various pathological settings can be inhibited by the blocking of the VEGF-C/VEGFR3 interaction using a ligand-binding soluble form of VEGFR3. Furthermore, the recently discovered plasticity of meningeal and lacteal lymphatic vessels provides novel opportunities for their manipulation in disease. Adenoviral and adeno-associated viral vectors (AAVs) provide suitable tools for establishing short- and long-term gene expression, respectively and adenoviral vectors have already been used in clinical trials. As an example, we describe here ways to manipulate the meningeal lymphatic vasculature in the adult mice via AAV-mediated gene delivery. The possibility of stimulation and inhibition of lymphangiogenesis in adult mice has enabled the analysis of the role and function of lymphatic vessels in mouse models of disease.
Alkuperäiskielienglanti
OtsikkoLymphangiogenesis : Methods and Protocols
ToimittajatGuillermo Oliver, Mark Kahn
Sivumäärä10
KustantajaHumana press
Julkaisupäivä22 syyskuuta 2018
Painos1st ed.
Sivut291-300
ISBN (painettu)978-1-4939-8711-5
ISBN (elektroninen)978-1-4939-8712-2
DOI - pysyväislinkit
TilaJulkaistu - 22 syyskuuta 2018
OKM-julkaisutyyppiA3 Kirjan tai muun kokoomateoksen osa

Julkaisusarja

Nimi Methods in Molecular Biology
KustantajaHumana Press
Numero1846
ISSN (painettu)1064-3745
ISSN (elektroninen)1940-6029

Tieteenalat

  • 3111 Biolääketieteet

Lainaa tätä

Karaman, S., Nurmi, H., Antila, S., & Alitalo, K. (2018). Stimulation and Inhibition of Lymphangiogenesis Via Adeno-Associated Viral Gene Delivery. teoksessa G. Oliver, & M. Kahn (Toimittajat), Lymphangiogenesis: Methods and Protocols (1st ed. toim., Sivut 291-300). ( Methods in Molecular Biology; Nro 1846). Humana press. https://doi.org/10.1007/978-1-4939-8712-2_19, https://doi.org/10.1007/978-1-4939-8712-2
Karaman, Sinem ; Nurmi, Harri ; Antila, Salli ; Alitalo, Kari. / Stimulation and Inhibition of Lymphangiogenesis Via Adeno-Associated Viral Gene Delivery. Lymphangiogenesis: Methods and Protocols. Toimittaja / Guillermo Oliver ; Mark Kahn. 1st ed. toim. Humana press, 2018. Sivut 291-300 ( Methods in Molecular Biology; 1846).
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abstract = "The lymphatic vessels can be selectively stimulated to grow in adult mice, rats and pigs by application of viral vectors expressing the lymphangiogenic factors VEGF-C or VEGF-D. Vice versa, lymphangiogenesis in various pathological settings can be inhibited by the blocking of the VEGF-C/VEGFR3 interaction using a ligand-binding soluble form of VEGFR3. Furthermore, the recently discovered plasticity of meningeal and lacteal lymphatic vessels provides novel opportunities for their manipulation in disease. Adenoviral and adeno-associated viral vectors (AAVs) provide suitable tools for establishing short- and long-term gene expression, respectively and adenoviral vectors have already been used in clinical trials. As an example, we describe here ways to manipulate the meningeal lymphatic vasculature in the adult mice via AAV-mediated gene delivery. The possibility of stimulation and inhibition of lymphangiogenesis in adult mice has enabled the analysis of the role and function of lymphatic vessels in mouse models of disease.",
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Karaman, S, Nurmi, H, Antila, S & Alitalo, K 2018, Stimulation and Inhibition of Lymphangiogenesis Via Adeno-Associated Viral Gene Delivery. julkaisussa G Oliver & M Kahn (toim), Lymphangiogenesis: Methods and Protocols. 1st ed. toim, Methods in Molecular Biology, Nro 1846, Humana press, Sivut 291-300. https://doi.org/10.1007/978-1-4939-8712-2_19, https://doi.org/10.1007/978-1-4939-8712-2

Stimulation and Inhibition of Lymphangiogenesis Via Adeno-Associated Viral Gene Delivery. / Karaman, Sinem; Nurmi, Harri; Antila, Salli; Alitalo, Kari.

Lymphangiogenesis: Methods and Protocols. toim. / Guillermo Oliver; Mark Kahn. 1st ed. toim. Humana press, 2018. s. 291-300 ( Methods in Molecular Biology; Nro 1846).

Tutkimustuotos: Artikkeli kirjassa/raportissa/konferenssijulkaisussaKirjan luku tai artikkeliTieteellinenvertaisarvioitu

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AU - Karaman, Sinem

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AU - Antila, Salli

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PY - 2018/9/22

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N2 - The lymphatic vessels can be selectively stimulated to grow in adult mice, rats and pigs by application of viral vectors expressing the lymphangiogenic factors VEGF-C or VEGF-D. Vice versa, lymphangiogenesis in various pathological settings can be inhibited by the blocking of the VEGF-C/VEGFR3 interaction using a ligand-binding soluble form of VEGFR3. Furthermore, the recently discovered plasticity of meningeal and lacteal lymphatic vessels provides novel opportunities for their manipulation in disease. Adenoviral and adeno-associated viral vectors (AAVs) provide suitable tools for establishing short- and long-term gene expression, respectively and adenoviral vectors have already been used in clinical trials. As an example, we describe here ways to manipulate the meningeal lymphatic vasculature in the adult mice via AAV-mediated gene delivery. The possibility of stimulation and inhibition of lymphangiogenesis in adult mice has enabled the analysis of the role and function of lymphatic vessels in mouse models of disease.

AB - The lymphatic vessels can be selectively stimulated to grow in adult mice, rats and pigs by application of viral vectors expressing the lymphangiogenic factors VEGF-C or VEGF-D. Vice versa, lymphangiogenesis in various pathological settings can be inhibited by the blocking of the VEGF-C/VEGFR3 interaction using a ligand-binding soluble form of VEGFR3. Furthermore, the recently discovered plasticity of meningeal and lacteal lymphatic vessels provides novel opportunities for their manipulation in disease. Adenoviral and adeno-associated viral vectors (AAVs) provide suitable tools for establishing short- and long-term gene expression, respectively and adenoviral vectors have already been used in clinical trials. As an example, we describe here ways to manipulate the meningeal lymphatic vasculature in the adult mice via AAV-mediated gene delivery. The possibility of stimulation and inhibition of lymphangiogenesis in adult mice has enabled the analysis of the role and function of lymphatic vessels in mouse models of disease.

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Karaman S, Nurmi H, Antila S, Alitalo K. Stimulation and Inhibition of Lymphangiogenesis Via Adeno-Associated Viral Gene Delivery. julkaisussa Oliver G, Kahn M, toimittajat, Lymphangiogenesis: Methods and Protocols. 1st ed. toim. Humana press. 2018. s. 291-300. ( Methods in Molecular Biology; 1846). https://doi.org/10.1007/978-1-4939-8712-2_19, https://doi.org/10.1007/978-1-4939-8712-2