STING agonism overcomes STAT3-mediated immunosuppression and adaptive resistance to PARP inhibition in ovarian cancer

Liya Ding; Qiwei Wang; Antons Martincuks; Michael J. Kearns; Tao Jiang; Ziying Lin; Xin Cheng; Changli Qian; Shaozhen Xie; Hye-Jung Kim; Inga-Maria Launonen; Anniina Färkkilä; Thomas M. Roberts; Gordon J. Freeman; Joyce F. Liu; Panagiotis A. Konstantinopoulos; Ursula Matulonis; Hua Yu; Jean J. Zhao

doi:10.1136/jitc-2022-005627

STING agonism overcomes STAT3-mediated immunosuppression and adaptive resistance to PARP inhibition in ovarian cancer

Liya Ding, Qiwei Wang, Antons Martincuks, Michael J. Kearns, Tao Jiang, Ziying Lin, Xin Cheng, Changli Qian, Shaozhen Xie, Hye-Jung Kim, Inga-Maria Launonen, Anniina Färkkilä, Thomas M. Roberts, Gordon J. Freeman, Joyce F. Liu, Panagiotis A. Konstantinopoulos, Ursula Matulonis, Hua Yu, Jean J. Zhao

Tutkimustuotos: Artikkelijulkaisu › Artikkeli › Tieteellinen › vertaisarvioitu

Alkuperäiskieli	englanti
Artikkeli	e005627
Lehti	Journal for Immunotherapy of Cancer
Vuosikerta	11
Numero	1
Sivumäärä	15
ISSN	2051-1426
DOI - pysyväislinkit	https://doi.org/10.1136/jitc-2022-005627
Tila	Julkaistu - tammik. 2023
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

Combination
Drug Therapy
Immunomodulation
Immunotherapy
Macrophages
Tumor Microenvironment
3122 Syöpätaudit

Pääsy asiakirjaan

10.1136/jitc-2022-005627

e005627.fullLopullinen julkaistu versio, 6,48 MBLisenssi: CC BY-NC

Discovery and therapeutic exploitation of immunological vulnerabilities in ovarian cancer
Färkkilä, A. (Projektinjohtaja), Kang, Z. (Osallistuja), Niemiec, I. (Osallistuja), Nagaraj, A. (Osallistuja), Perez Villatoro, F. R. (Osallistuja), Chernenko, A. (Osallistuja) & Shah, S. (Osallistuja)
01/01/2021 → 31/12/2023
Projekti: Helsingin yliopiston kolmivuotinen tutkimushanke

Siteeraa tätä

Ding, L., Wang, Q., Martincuks, A., Kearns, M. J., Jiang, T., Lin, Z., Cheng, X., Qian, C., Xie, S., Kim, H.-J., Launonen, I.-M., Färkkilä, A., Roberts, T. M., Freeman, G. J., Liu, J. F., Konstantinopoulos, P. A., Matulonis, U., Yu, H., & Zhao, J. J. (2023). STING agonism overcomes STAT3-mediated immunosuppression and adaptive resistance to PARP inhibition in ovarian cancer. Journal for Immunotherapy of Cancer, 11(1), Artikkeli e005627. https://doi.org/10.1136/jitc-2022-005627

@article{5a9204d9cd8e4c8ab2a16dba95bb4b69,

title = "STING agonism overcomes STAT3-mediated immunosuppression and adaptive resistance to PARP inhibition in ovarian cancer",

keywords = "Combination, Drug Therapy, Immunomodulation, Immunotherapy, Macrophages, Tumor Microenvironment, 3122 Cancers",

author = "Liya Ding and Qiwei Wang and Antons Martincuks and Kearns, {Michael J.} and Tao Jiang and Ziying Lin and Xin Cheng and Changli Qian and Shaozhen Xie and Hye-Jung Kim and Inga-Maria Launonen and Anniina F{\"a}rkkil{\"a} and Roberts, {Thomas M.} and Freeman, {Gordon J.} and Liu, {Joyce F.} and Konstantinopoulos, {Panagiotis A.} and Ursula Matulonis and Hua Yu and Zhao, {Jean J.}",

year = "2023",

month = jan,

doi = "10.1136/jitc-2022-005627",

language = "English",

volume = "11",

journal = "Journal for Immunotherapy of Cancer",

issn = "2051-1426",

publisher = "BMJ PUBLISHING GROUP",

number = "1",

}

Ding, L, Wang, Q, Martincuks, A, Kearns, MJ, Jiang, T, Lin, Z, Cheng, X, Qian, C, Xie, S, Kim, H-J, Launonen, I-M , Färkkilä, A, Roberts, TM, Freeman, GJ, Liu, JF, Konstantinopoulos, PA, Matulonis, U, Yu, H & Zhao, JJ 2023, 'STING agonism overcomes STAT3-mediated immunosuppression and adaptive resistance to PARP inhibition in ovarian cancer', Journal for Immunotherapy of Cancer, Vuosikerta 11, Nro 1, e005627. https://doi.org/10.1136/jitc-2022-005627

TY - JOUR

T1 - STING agonism overcomes STAT3-mediated immunosuppression and adaptive resistance to PARP inhibition in ovarian cancer

AU - Ding, Liya

AU - Wang, Qiwei

AU - Martincuks, Antons

AU - Kearns, Michael J.

AU - Jiang, Tao

AU - Lin, Ziying

AU - Cheng, Xin

AU - Qian, Changli

AU - Xie, Shaozhen

AU - Kim, Hye-Jung

AU - Launonen, Inga-Maria

AU - Färkkilä, Anniina

AU - Roberts, Thomas M.

AU - Freeman, Gordon J.

AU - Liu, Joyce F.

AU - Konstantinopoulos, Panagiotis A.

AU - Matulonis, Ursula

AU - Yu, Hua

AU - Zhao, Jean J.

PY - 2023/1

Y1 - 2023/1

KW - Combination

KW - Drug Therapy

KW - Immunomodulation

KW - Immunotherapy

KW - Macrophages

KW - Tumor Microenvironment

KW - 3122 Cancers

U2 - 10.1136/jitc-2022-005627

DO - 10.1136/jitc-2022-005627

M3 - Article

C2 - 36609487

SN - 2051-1426

VL - 11

JO - Journal for Immunotherapy of Cancer

JF - Journal for Immunotherapy of Cancer

IS - 1

M1 - e005627

ER -

STING agonism overcomes STAT3-mediated immunosuppression and adaptive resistance to PARP inhibition in ovarian cancer

Tieteenalat

Pääsy asiakirjaan

Projektit

Discovery and therapeutic exploitation of immunological vulnerabilities in ovarian cancer

Siteeraa tätä