Strategies for coordinating experimentation and modeling in integrative systems biology

Miles MacLeod, Nancy J. Nersessian

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Kuvaus

In this paper,we provide a novel analysis of the affordances and trade‐offs of different strategies for integrating model‐building and experimentation in integrative systems biology. Unimodal strategies rely on collaboration between experimenters and modelers in distinct laboratories. In a bimodal strategy modelers perform their own experiments. Each option has advantages and challenges. In the case of the labs we studied, the choice of strategy often depends on preferences held by lab directors as to the strategy that best achieves certain philosophical objectives concerning what they see as the aims of modeling in systems biology and the epistemic standards to apply to it.We identify an important connection between philosophical divisions in systems biology and the structure of research in systems biology. Better knowledge of these strategies and their philosophical motivations provide insight behind the diversifying structure of the field, and can help lab directors understand the challenges their researchers face, as well as the training and lab organization options available.
Alkuperäiskielienglanti
LehtiJournal of Experimental Zoology. Part B: Molecular and Developmental Evolution
Vuosikerta322
Numero4
Sivut230–239
ISSN1552-5007
DOI - pysyväislinkit
TilaJulkaistu - 27 maaliskuuta 2014
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

  • 1181 Ekologia, evoluutiobiologia
  • 1182 Biokemia, solu- ja molekyylibiologia
  • 611 Filosofia

Lainaa tätä

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abstract = "In this paper,we provide a novel analysis of the affordances and trade‐offs of different strategies for integrating model‐building and experimentation in integrative systems biology. Unimodal strategies rely on collaboration between experimenters and modelers in distinct laboratories. In a bimodal strategy modelers perform their own experiments. Each option has advantages and challenges. In the case of the labs we studied, the choice of strategy often depends on preferences held by lab directors as to the strategy that best achieves certain philosophical objectives concerning what they see as the aims of modeling in systems biology and the epistemic standards to apply to it.We identify an important connection between philosophical divisions in systems biology and the structure of research in systems biology. Better knowledge of these strategies and their philosophical motivations provide insight behind the diversifying structure of the field, and can help lab directors understand the challenges their researchers face, as well as the training and lab organization options available.",
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Strategies for coordinating experimentation and modeling in integrative systems biology. / MacLeod, Miles; Nersessian, Nancy J. .

julkaisussa: Journal of Experimental Zoology. Part B: Molecular and Developmental Evolution, Vuosikerta 322, Nro 4, 27.03.2014, s. 230–239.

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

TY - JOUR

T1 - Strategies for coordinating experimentation and modeling in integrative systems biology

AU - MacLeod, Miles

AU - Nersessian, Nancy J.

PY - 2014/3/27

Y1 - 2014/3/27

N2 - In this paper,we provide a novel analysis of the affordances and trade‐offs of different strategies for integrating model‐building and experimentation in integrative systems biology. Unimodal strategies rely on collaboration between experimenters and modelers in distinct laboratories. In a bimodal strategy modelers perform their own experiments. Each option has advantages and challenges. In the case of the labs we studied, the choice of strategy often depends on preferences held by lab directors as to the strategy that best achieves certain philosophical objectives concerning what they see as the aims of modeling in systems biology and the epistemic standards to apply to it.We identify an important connection between philosophical divisions in systems biology and the structure of research in systems biology. Better knowledge of these strategies and their philosophical motivations provide insight behind the diversifying structure of the field, and can help lab directors understand the challenges their researchers face, as well as the training and lab organization options available.

AB - In this paper,we provide a novel analysis of the affordances and trade‐offs of different strategies for integrating model‐building and experimentation in integrative systems biology. Unimodal strategies rely on collaboration between experimenters and modelers in distinct laboratories. In a bimodal strategy modelers perform their own experiments. Each option has advantages and challenges. In the case of the labs we studied, the choice of strategy often depends on preferences held by lab directors as to the strategy that best achieves certain philosophical objectives concerning what they see as the aims of modeling in systems biology and the epistemic standards to apply to it.We identify an important connection between philosophical divisions in systems biology and the structure of research in systems biology. Better knowledge of these strategies and their philosophical motivations provide insight behind the diversifying structure of the field, and can help lab directors understand the challenges their researchers face, as well as the training and lab organization options available.

KW - 1181 Ecology, evolutionary biology

KW - 1182 Biochemistry, cell and molecular biology

KW - 611 Philosophy

U2 - 10.1002/jez.b.22568

DO - 10.1002/jez.b.22568

M3 - Article

VL - 322

SP - 230

EP - 239

JO - Journal of Experimental Zoology. Part B: Molecular and Developmental Evolution

JF - Journal of Experimental Zoology. Part B: Molecular and Developmental Evolution

SN - 1552-5007

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ER -