Structure, assembly and inhibition of the Toxoplasma gondii respiratory chain supercomplex

Andrew E. MacLean; Shikha Shikha; Mariana Ferreira Silva; Max J. Gramelspacher; Aaron Nilsen; Katherine M. Liebman; Sovitj Pou; Rolf W. Winter; Amit Meir; Michael K. Riscoe; J. Stone Doggett; Lilach Sheiner; Alexander Muhleip

doi:10.1038/s41594-025-01531-7

Structure, assembly and inhibition of the Toxoplasma gondii respiratory chain supercomplex

Andrew E. MacLean
, Shikha Shikha
, Mariana Ferreira Silva
, Max J. Gramelspacher
, Aaron Nilsen
, Katherine M. Liebman
, Sovitj Pou
, Rolf W. Winter
, Amit Meir
, Michael K. Riscoe
, J. Stone Doggett
, Lilach Sheiner
, Alexander Muhleip

Tutkimustuotos: Artikkelijulkaisu › Artikkeli › Tieteellinen › vertaisarvioitu

Alkuperäiskieli	englanti
Lehti	Nature Structural and Molecular Biology
Vuosikerta	32
Numero	8
Sivut	1424–1433
Sivumäärä	10
ISSN	1545-9993
DOI - pysyväislinkit	https://doi.org/10.1038/s41594-025-01531-7
Tila	Julkaistu - 19 toukok. 2025
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Lisätietoja

Correction: 10.1038/s41594-026-01824-5

Tieteenalat

1182 Biokemia, solu- ja molekyylibiologia

Pääsy asiakirjaan

10.1038/s41594-025-01531-7Lisenssi: CC BY

s41594-025-01531-7Lopullinen julkaistu versio, 26,9 MBLisenssi: CC BY

Siteeraa tätä

MacLean, A. E., Shikha, S., Ferreira Silva, M., Gramelspacher, M. J., Nilsen, A., Liebman, K. M., Pou, S., Winter, R. W., Meir, A., Riscoe, M. K., Doggett, J. S., Sheiner, L., & Muhleip, A. (2025). Structure, assembly and inhibition of the Toxoplasma gondii respiratory chain supercomplex. Nature Structural and Molecular Biology, 32(8), 1424–1433. https://doi.org/10.1038/s41594-025-01531-7

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title = "Structure, assembly and inhibition of the Toxoplasma gondii respiratory chain supercomplex",

keywords = "Cytochrome-c, Hydrophobicity scale, Atovaquone-binding, Complex, Visualization, Mutations, Proteins, System, Domain, Site, 1182 Biochemistry, cell and molecular biology",

author = "MacLean, \{Andrew E.\} and Shikha Shikha and \{Ferreira Silva\}, Mariana and Gramelspacher, \{Max J.\} and Aaron Nilsen and Liebman, \{Katherine M.\} and Sovitj Pou and Winter, \{Rolf W.\} and Amit Meir and Riscoe, \{Michael K.\} and Doggett, \{J. Stone\} and Lilach Sheiner and Alexander Muhleip",

note = "Correction: 10.1038/s41594-026-01824-5",

year = "2025",

month = may,

day = "19",

doi = "10.1038/s41594-025-01531-7",

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MacLean, AE, Shikha, S, Ferreira Silva, M, Gramelspacher, MJ, Nilsen, A, Liebman, KM, Pou, S, Winter, RW, Meir, A, Riscoe, MK, Doggett, JS, Sheiner, L & Muhleip, A 2025, 'Structure, assembly and inhibition of the Toxoplasma gondii respiratory chain supercomplex', Nature Structural and Molecular Biology, Vuosikerta 32, Nro 8, Sivut 1424–1433. https://doi.org/10.1038/s41594-025-01531-7

TY - JOUR

T1 - Structure, assembly and inhibition of the Toxoplasma gondii respiratory chain supercomplex

AU - MacLean, Andrew E.

AU - Shikha, Shikha

AU - Ferreira Silva, Mariana

AU - Gramelspacher, Max J.

AU - Nilsen, Aaron

AU - Liebman, Katherine M.

AU - Pou, Sovitj

AU - Winter, Rolf W.

AU - Meir, Amit

AU - Riscoe, Michael K.

AU - Doggett, J. Stone

AU - Sheiner, Lilach

AU - Muhleip, Alexander

N1 - Correction: 10.1038/s41594-026-01824-5

PY - 2025/5/19

Y1 - 2025/5/19

KW - Cytochrome-c

KW - Hydrophobicity scale

KW - Atovaquone-binding

KW - Complex

KW - Visualization

KW - Mutations

KW - Proteins

KW - System

KW - Domain

KW - Site

KW - 1182 Biochemistry, cell and molecular biology

U2 - 10.1038/s41594-025-01531-7

DO - 10.1038/s41594-025-01531-7

M3 - Article

C2 - 40389671

SN - 1545-9993

VL - 32

SP - 1424

EP - 1433

JO - Nature Structural and Molecular Biology

JF - Nature Structural and Molecular Biology

IS - 8

ER -