Survival of nisin activity in intestinal environment

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Kuvaus

The sensitivity of nisin to proteolytical breakdown in intestinal environment was studied in an ex vivo model using jejunal chyme from fistulated dogs. Sixty six percentage of the added nisin retained induction activity after 30 min incubation in jejunal chyme, indicating that nisin has potential to be used as an inducing agent in in situ delivery systems of bioactive peptides and proteins by genetically modified bacteria in the intestine.
Alkuperäiskielienglanti
LehtiBiotechnology Letters
Vuosikerta31
Numero8
Sivut1229-1232
Sivumäärä4
ISSN0141-5492
DOI - pysyväislinkit
TilaJulkaistu - 2009
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

  • 118 Biotieteet

Lainaa tätä

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title = "Survival of nisin activity in intestinal environment",
abstract = "The sensitivity of nisin to proteolytical breakdown in intestinal environment was studied in an ex vivo model using jejunal chyme from fistulated dogs. Sixty six percentage of the added nisin retained induction activity after 30 min incubation in jejunal chyme, indicating that nisin has potential to be used as an inducing agent in in situ delivery systems of bioactive peptides and proteins by genetically modified bacteria in the intestine.",
keywords = "Chyme, Intestine, Nisin, Shelf life, LACTOCOCCUS-LACTIS, 118 Biological sciences",
author = "J. Reunanen and Saris, {P. E. J.}",
year = "2009",
doi = "10.1007/s10529-009-9995-3",
language = "English",
volume = "31",
pages = "1229--1232",
journal = "Biotechnology Letters",
issn = "0141-5492",
publisher = "SPRINGER NEW YORK LLC",
number = "8",

}

Survival of nisin activity in intestinal environment. / Reunanen, J.; Saris, P. E. J.

julkaisussa: Biotechnology Letters, Vuosikerta 31, Nro 8, 2009, s. 1229-1232.

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

TY - JOUR

T1 - Survival of nisin activity in intestinal environment

AU - Reunanen, J.

AU - Saris, P. E. J.

PY - 2009

Y1 - 2009

N2 - The sensitivity of nisin to proteolytical breakdown in intestinal environment was studied in an ex vivo model using jejunal chyme from fistulated dogs. Sixty six percentage of the added nisin retained induction activity after 30 min incubation in jejunal chyme, indicating that nisin has potential to be used as an inducing agent in in situ delivery systems of bioactive peptides and proteins by genetically modified bacteria in the intestine.

AB - The sensitivity of nisin to proteolytical breakdown in intestinal environment was studied in an ex vivo model using jejunal chyme from fistulated dogs. Sixty six percentage of the added nisin retained induction activity after 30 min incubation in jejunal chyme, indicating that nisin has potential to be used as an inducing agent in in situ delivery systems of bioactive peptides and proteins by genetically modified bacteria in the intestine.

KW - Chyme

KW - Intestine

KW - Nisin

KW - Shelf life

KW - LACTOCOCCUS-LACTIS

KW - 118 Biological sciences

U2 - 10.1007/s10529-009-9995-3

DO - 10.1007/s10529-009-9995-3

M3 - Article

VL - 31

SP - 1229

EP - 1232

JO - Biotechnology Letters

JF - Biotechnology Letters

SN - 0141-5492

IS - 8

ER -