Systemic Blockade of Clever-1 Elicits Lymphocyte Activation Alongside Checkpoint Molecule Downregulation in Patients with Solid Tumors: Results from a Phase I/II Clinical Trial

Reetta Virtakoivu; Jenna H. Rannikko; Miro Viitala; Felix Vaura; Akira Takeda; Tapio Lonnberg; Jussi Koivunen; Panu Jaakkola; Annika Pasanen; Shishir Shetty; Maja J. A. de Jonge; Debbie Robbrecht; Yuk Ting Ma; Tanja Skyttä; Anna Minchom; Sirpa Jalkanen; Matti K. Karvonen; Jami Mandelin; Petri Bono; Maija Hollmen

doi:10.1158/1078-0432.CCR-20-4862

Systemic Blockade of Clever-1 Elicits Lymphocyte Activation Alongside Checkpoint Molecule Downregulation in Patients with Solid Tumors: Results from a Phase I/II Clinical Trial

Reetta Virtakoivu, Jenna H. Rannikko, Miro Viitala, Felix Vaura, Akira Takeda, Tapio Lonnberg, Jussi Koivunen, Panu Jaakkola, Annika Pasanen, Shishir Shetty, Maja J. A. de Jonge, Debbie Robbrecht, Yuk Ting Ma, Tanja Skyttä, Anna Minchom, Sirpa Jalkanen, Matti K. Karvonen, Jami Mandelin, Petri Bono, Maija Hollmen

Tutkimustuotos: Artikkelijulkaisu › Artikkeli › Tieteellinen › vertaisarvioitu

Alkuperäiskieli	englanti
Lehti	Clinical Cancer Research
Vuosikerta	27
Numero	15
Sivut	4205-4220
Sivumäärä	16
ISSN	1078-0432
DOI - pysyväislinkit	https://doi.org/10.1158/1078-0432.CCR-20-4862
Tila	Julkaistu - 1 elok. 2021
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

3122 Syöpätaudit

Pääsy asiakirjaan

10.1158/1078-0432.CCR-20-4862

4205.fullLopullinen julkaistu versio, 2,22 MBLisenssi: CC BY-NC-ND

Siteeraa tätä

Virtakoivu, R., Rannikko, J. H., Viitala, M., Vaura, F., Takeda, A., Lonnberg, T., Koivunen, J., Jaakkola, P., Pasanen, A., Shetty, S., de Jonge, M. J. A., Robbrecht, D., Ma, Y. T., Skyttä, T., Minchom, A., Jalkanen, S., Karvonen, M. K., Mandelin, J., Bono, P., & Hollmen, M. (2021). Systemic Blockade of Clever-1 Elicits Lymphocyte Activation Alongside Checkpoint Molecule Downregulation in Patients with Solid Tumors: Results from a Phase I/II Clinical Trial. Clinical Cancer Research, 27(15), 4205-4220. https://doi.org/10.1158/1078-0432.CCR-20-4862

@article{2891657cd37348a8ba4237ad4f1637f7,

title = "Systemic Blockade of Clever-1 Elicits Lymphocyte Activation Alongside Checkpoint Molecule Downregulation in Patients with Solid Tumors: Results from a Phase I/II Clinical Trial",

keywords = "DENDRITIC CELLS, T-CELLS, RECEPTOR, MACROPHAGES, DIFFERENTIATION, HOMEOSTASIS, ENVIRONMENT, STABILIN-1, PATHWAYS, 3122 Cancers",

author = "Reetta Virtakoivu and Rannikko, {Jenna H.} and Miro Viitala and Felix Vaura and Akira Takeda and Tapio Lonnberg and Jussi Koivunen and Panu Jaakkola and Annika Pasanen and Shishir Shetty and {de Jonge}, {Maja J. A.} and Debbie Robbrecht and Ma, {Yuk Ting} and Tanja Skytt{\"a} and Anna Minchom and Sirpa Jalkanen and Karvonen, {Matti K.} and Jami Mandelin and Petri Bono and Maija Hollmen",

year = "2021",

month = aug,

day = "1",

doi = "10.1158/1078-0432.CCR-20-4862",

language = "English",

volume = "27",

pages = "4205--4220",

journal = "Clinical Cancer Research",

issn = "1078-0432",

publisher = "American Association for Cancer Research",

number = "15",

}

Virtakoivu, R, Rannikko, JH, Viitala, M, Vaura, F, Takeda, A, Lonnberg, T, Koivunen, J, Jaakkola, P , Pasanen, A, Shetty, S, de Jonge, MJA, Robbrecht, D, Ma, YT, Skyttä, T, Minchom, A, Jalkanen, S, Karvonen, MK, Mandelin, J, Bono, P & Hollmen, M 2021, 'Systemic Blockade of Clever-1 Elicits Lymphocyte Activation Alongside Checkpoint Molecule Downregulation in Patients with Solid Tumors: Results from a Phase I/II Clinical Trial', Clinical Cancer Research, Vuosikerta 27, Nro 15, Sivut 4205-4220. https://doi.org/10.1158/1078-0432.CCR-20-4862

Systemic Blockade of Clever-1 Elicits Lymphocyte Activation Alongside Checkpoint Molecule Downregulation in Patients with Solid Tumors : Results from a Phase I/II Clinical Trial. / Virtakoivu, Reetta; Rannikko, Jenna H.; Viitala, Miro et al.

julkaisussa: Clinical Cancer Research, Vuosikerta 27, Nro 15, 01.08.2021, s. 4205-4220.

Tutkimustuotos: Artikkelijulkaisu › Artikkeli › Tieteellinen › vertaisarvioitu

TY - JOUR

T1 - Systemic Blockade of Clever-1 Elicits Lymphocyte Activation Alongside Checkpoint Molecule Downregulation in Patients with Solid Tumors

T2 - Results from a Phase I/II Clinical Trial

AU - Virtakoivu, Reetta

AU - Rannikko, Jenna H.

AU - Viitala, Miro

AU - Vaura, Felix

AU - Takeda, Akira

AU - Lonnberg, Tapio

AU - Koivunen, Jussi

AU - Jaakkola, Panu

AU - Pasanen, Annika

AU - Shetty, Shishir

AU - de Jonge, Maja J. A.

AU - Robbrecht, Debbie

AU - Ma, Yuk Ting

AU - Skyttä, Tanja

AU - Minchom, Anna

AU - Jalkanen, Sirpa

AU - Karvonen, Matti K.

AU - Mandelin, Jami

AU - Bono, Petri

AU - Hollmen, Maija

PY - 2021/8/1

Y1 - 2021/8/1

KW - DENDRITIC CELLS

KW - T-CELLS

KW - RECEPTOR

KW - MACROPHAGES

KW - DIFFERENTIATION

KW - HOMEOSTASIS

KW - ENVIRONMENT

KW - STABILIN-1

KW - PATHWAYS

KW - 3122 Cancers

U2 - 10.1158/1078-0432.CCR-20-4862

DO - 10.1158/1078-0432.CCR-20-4862

M3 - Article

VL - 27

SP - 4205

EP - 4220

JO - Clinical Cancer Research

JF - Clinical Cancer Research

SN - 1078-0432

IS - 15

ER -