Tailoring porous silicon for biomedical applications: from drug delivery to cancer immunotherapy

Tutkimustuotos: ArtikkelijulkaisuKatsausartikkeliTieteellinenvertaisarvioitu

Kuvaus

In the past two decades, porous silicon (PSi) has attracted increasing attention for its potential biomedical applications. With its controllable geometry, tunable nanoporous structure, large pore volume/high specific surface area and versatile surface chemistry, PSi shows significant advantages over conventional drug carriers. In this review, we overview the recent progresses of PSi in drug delivery and cancer immunotherapy. First, we provide an overview of the fabrication of PSi with various geometric structures and highlight how the unique geometry of PSi facilitates its biomedical applications, especially for drug delivery. Second, surface chemistry and modification of PSi are discussed in relation to strengthen its performance in drug delivery and bioimaging. Then, emerging technologies for engineering PSi-based composites are summarized. This review also highlights the emerging advances of PSi in the context of cancer immunotherapy. Overall, the very promising research results encourage further exploration of PSi for biomedical applications, particularly in drug delivery and cancer immunotherapy, and future translation of PSi into clinical applications.
Alkuperäiskielienglanti
Artikkeli1703740
LehtiAdvanced Materials
Vuosikerta30
Numero24
Sivumäärä38
ISSN0935-9648
DOI - pysyväislinkit
TilaJulkaistu - 13 kesäkuuta 2018
OKM-julkaisutyyppiA2 Katsausartikkeli tieteellisessä aikakauslehdessä

Tieteenalat

  • 116 Kemia
  • 317 Farmasia
  • 221 Nanoteknologia
  • 216 Materiaalitekniikka

Lainaa tätä

@article{2e695baaa2f34e4a9755078317cf06c8,
title = "Tailoring porous silicon for biomedical applications: from drug delivery to cancer immunotherapy",
abstract = "In the past two decades, porous silicon (PSi) has attracted increasing attention for its potential biomedical applications. With its controllable geometry, tunable nanoporous structure, large pore volume/high specific surface area and versatile surface chemistry, PSi shows significant advantages over conventional drug carriers. In this review, we overview the recent progresses of PSi in drug delivery and cancer immunotherapy. First, we provide an overview of the fabrication of PSi with various geometric structures and highlight how the unique geometry of PSi facilitates its biomedical applications, especially for drug delivery. Second, surface chemistry and modification of PSi are discussed in relation to strengthen its performance in drug delivery and bioimaging. Then, emerging technologies for engineering PSi-based composites are summarized. This review also highlights the emerging advances of PSi in the context of cancer immunotherapy. Overall, the very promising research results encourage further exploration of PSi for biomedical applications, particularly in drug delivery and cancer immunotherapy, and future translation of PSi into clinical applications.",
keywords = "116 Chemical sciences, 317 Pharmacy, 221 Nano-technology, 216 Materials engineering, drug delivery, immunotherapy, nanomedicine, porous silicon, surface modification, PLGA COMPOSITE MICROSPHERES, WOUND-HEALING APPLICATIONS, PLASMA-PROTEIN ADSORPTION, CORE-SHELL NANOPARTICLES, IN-VIVO ASSESSMENT, MESOPOROUS SILICON, SURFACE-CHEMISTRY, BREAST-CANCER, COMBINATION THERAPY, MULTISTAGE NANOVECTORS",
author = "Wei Li and Zehua Liu and Flavia Fontana and Yaping Ding and Dongfei Liu and Hirvonen, {Jouni Tapio} and {Almeida Santos}, Helder",
year = "2018",
month = "6",
day = "13",
doi = "10.1002/adma.201703740",
language = "English",
volume = "30",
journal = "Advanced Materials",
issn = "0935-9648",
publisher = "Wiley-VCH",
number = "24",

}

Tailoring porous silicon for biomedical applications: from drug delivery to cancer immunotherapy. / Li, Wei; Liu, Zehua; Fontana, Flavia; Ding, Yaping; Liu, Dongfei; Hirvonen, Jouni Tapio; Almeida Santos, Helder.

julkaisussa: Advanced Materials, Vuosikerta 30, Nro 24, 1703740, 13.06.2018.

Tutkimustuotos: ArtikkelijulkaisuKatsausartikkeliTieteellinenvertaisarvioitu

TY - JOUR

T1 - Tailoring porous silicon for biomedical applications: from drug delivery to cancer immunotherapy

AU - Li, Wei

AU - Liu, Zehua

AU - Fontana, Flavia

AU - Ding, Yaping

AU - Liu, Dongfei

AU - Hirvonen, Jouni Tapio

AU - Almeida Santos, Helder

PY - 2018/6/13

Y1 - 2018/6/13

N2 - In the past two decades, porous silicon (PSi) has attracted increasing attention for its potential biomedical applications. With its controllable geometry, tunable nanoporous structure, large pore volume/high specific surface area and versatile surface chemistry, PSi shows significant advantages over conventional drug carriers. In this review, we overview the recent progresses of PSi in drug delivery and cancer immunotherapy. First, we provide an overview of the fabrication of PSi with various geometric structures and highlight how the unique geometry of PSi facilitates its biomedical applications, especially for drug delivery. Second, surface chemistry and modification of PSi are discussed in relation to strengthen its performance in drug delivery and bioimaging. Then, emerging technologies for engineering PSi-based composites are summarized. This review also highlights the emerging advances of PSi in the context of cancer immunotherapy. Overall, the very promising research results encourage further exploration of PSi for biomedical applications, particularly in drug delivery and cancer immunotherapy, and future translation of PSi into clinical applications.

AB - In the past two decades, porous silicon (PSi) has attracted increasing attention for its potential biomedical applications. With its controllable geometry, tunable nanoporous structure, large pore volume/high specific surface area and versatile surface chemistry, PSi shows significant advantages over conventional drug carriers. In this review, we overview the recent progresses of PSi in drug delivery and cancer immunotherapy. First, we provide an overview of the fabrication of PSi with various geometric structures and highlight how the unique geometry of PSi facilitates its biomedical applications, especially for drug delivery. Second, surface chemistry and modification of PSi are discussed in relation to strengthen its performance in drug delivery and bioimaging. Then, emerging technologies for engineering PSi-based composites are summarized. This review also highlights the emerging advances of PSi in the context of cancer immunotherapy. Overall, the very promising research results encourage further exploration of PSi for biomedical applications, particularly in drug delivery and cancer immunotherapy, and future translation of PSi into clinical applications.

KW - 116 Chemical sciences

KW - 317 Pharmacy

KW - 221 Nano-technology

KW - 216 Materials engineering

KW - drug delivery

KW - immunotherapy

KW - nanomedicine

KW - porous silicon

KW - surface modification

KW - PLGA COMPOSITE MICROSPHERES

KW - WOUND-HEALING APPLICATIONS

KW - PLASMA-PROTEIN ADSORPTION

KW - CORE-SHELL NANOPARTICLES

KW - IN-VIVO ASSESSMENT

KW - MESOPOROUS SILICON

KW - SURFACE-CHEMISTRY

KW - BREAST-CANCER

KW - COMBINATION THERAPY

KW - MULTISTAGE NANOVECTORS

UR - http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1521-4095

U2 - 10.1002/adma.201703740

DO - 10.1002/adma.201703740

M3 - Review Article

VL - 30

JO - Advanced Materials

JF - Advanced Materials

SN - 0935-9648

IS - 24

M1 - 1703740

ER -