Kuvaus

Telomere length has been suggested a biomarker of aging and is associated with several chronic diseases. However, the association between telomere length and physical performance is not well known. Using both cross-sectional and longitudinal data, we studied 582 women and 453 men from the Helsinki Birth Cohort Study at two time-points; a baseline examination in 2001-2004 at a mean age of 61 years and a follow-up examination approximately 10 years later in 2011-2013. Telomere length was measured both at baseline and at follow-up using real-time quantitative polymerase chain reaction. Physical performance was evaluated only at follow-up using the Senior Fitness Test (SFT), which assesses strength, flexibility and endurance. In women, shorter telomere length at follow-up (p = 0.044) and greater telomere attrition during follow-up time (p = 0.022) were associated with poorer physical performance after adjusting for covariates (age at baseline, smoking status, body mass index at baseline, follow-up time and educational attainment). No similar associations were found for men. This indicates that, at least in women, telomere length could potentially be used as a biomarker for physical performance, however, more longitudinal studies are needed to confirm this association.
Alkuperäiskielienglanti
Artikkeli111145
LehtiMechanisms of Ageing and Development
Vuosikerta183
ISSN0047-6374
DOI - pysyväislinkit
TilaJulkaistu - 3 syyskuuta 2019
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

  • 3142 Kansanterveystiede, ympäristö ja työterveys

Lainaa tätä

Åström, Max J. ; von Bonsdorff, Mikaela B. ; Perälä, Mia-Maria ; Salonen, Minna K. ; Rantanen, Taina ; Kajantie, Eero ; Simonen, Mika ; Pohjolainen, Pertti ; Haapanen, Markus J. ; Guzzardi, Maria A. ; Iozzo, Patricia ; Kautiainen, Hannu ; Eriksson, Johan G. / Telomere length and physical performance among older people – the Helsinki Birth Cohort Study. Julkaisussa: Mechanisms of Ageing and Development. 2019 ; Vuosikerta 183.
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title = "Telomere length and physical performance among older people – the Helsinki Birth Cohort Study",
abstract = "Telomere length has been suggested a biomarker of aging and is associated with several chronic diseases. However, the association between telomere length and physical performance is not well known. Using both cross-sectional and longitudinal data, we studied 582 women and 453 men from the Helsinki Birth Cohort Study at two time-points; a baseline examination in 2001-2004 at a mean age of 61 years and a follow-up examination approximately 10 years later in 2011-2013. Telomere length was measured both at baseline and at follow-up using real-time quantitative polymerase chain reaction. Physical performance was evaluated only at follow-up using the Senior Fitness Test (SFT), which assesses strength, flexibility and endurance. In women, shorter telomere length at follow-up (p = 0.044) and greater telomere attrition during follow-up time (p = 0.022) were associated with poorer physical performance after adjusting for covariates (age at baseline, smoking status, body mass index at baseline, follow-up time and educational attainment). No similar associations were found for men. This indicates that, at least in women, telomere length could potentially be used as a biomarker for physical performance, however, more longitudinal studies are needed to confirm this association.",
keywords = "3142 Public health care science, environmental and occupational health, Biomarkers, Physical function, Aging, Epidemiology",
author = "{\AA}str{\"o}m, {Max J.} and {von Bonsdorff}, {Mikaela B.} and Mia-Maria Per{\"a}l{\"a} and Salonen, {Minna K.} and Taina Rantanen and Eero Kajantie and Mika Simonen and Pertti Pohjolainen and Haapanen, {Markus J.} and Guzzardi, {Maria A.} and Patricia Iozzo and Hannu Kautiainen and Eriksson, {Johan G.}",
year = "2019",
month = "9",
day = "3",
doi = "10.1016/j.mad.2019.111145",
language = "English",
volume = "183",
journal = "Mechanisms of Ageing and Development",
issn = "0047-6374",
publisher = "ELSEVIER IRELAND LTD",

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Telomere length and physical performance among older people – the Helsinki Birth Cohort Study. / Åström, Max J.; von Bonsdorff, Mikaela B.; Perälä, Mia-Maria; Salonen, Minna K.; Rantanen, Taina; Kajantie, Eero; Simonen, Mika; Pohjolainen, Pertti; Haapanen, Markus J.; Guzzardi, Maria A.; Iozzo, Patricia; Kautiainen, Hannu; Eriksson, Johan G.

julkaisussa: Mechanisms of Ageing and Development, Vuosikerta 183, 111145, 03.09.2019.

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

TY - JOUR

T1 - Telomere length and physical performance among older people – the Helsinki Birth Cohort Study

AU - Åström, Max J.

AU - von Bonsdorff, Mikaela B.

AU - Perälä, Mia-Maria

AU - Salonen, Minna K.

AU - Rantanen, Taina

AU - Kajantie, Eero

AU - Simonen, Mika

AU - Pohjolainen, Pertti

AU - Haapanen, Markus J.

AU - Guzzardi, Maria A.

AU - Iozzo, Patricia

AU - Kautiainen, Hannu

AU - Eriksson, Johan G.

PY - 2019/9/3

Y1 - 2019/9/3

N2 - Telomere length has been suggested a biomarker of aging and is associated with several chronic diseases. However, the association between telomere length and physical performance is not well known. Using both cross-sectional and longitudinal data, we studied 582 women and 453 men from the Helsinki Birth Cohort Study at two time-points; a baseline examination in 2001-2004 at a mean age of 61 years and a follow-up examination approximately 10 years later in 2011-2013. Telomere length was measured both at baseline and at follow-up using real-time quantitative polymerase chain reaction. Physical performance was evaluated only at follow-up using the Senior Fitness Test (SFT), which assesses strength, flexibility and endurance. In women, shorter telomere length at follow-up (p = 0.044) and greater telomere attrition during follow-up time (p = 0.022) were associated with poorer physical performance after adjusting for covariates (age at baseline, smoking status, body mass index at baseline, follow-up time and educational attainment). No similar associations were found for men. This indicates that, at least in women, telomere length could potentially be used as a biomarker for physical performance, however, more longitudinal studies are needed to confirm this association.

AB - Telomere length has been suggested a biomarker of aging and is associated with several chronic diseases. However, the association between telomere length and physical performance is not well known. Using both cross-sectional and longitudinal data, we studied 582 women and 453 men from the Helsinki Birth Cohort Study at two time-points; a baseline examination in 2001-2004 at a mean age of 61 years and a follow-up examination approximately 10 years later in 2011-2013. Telomere length was measured both at baseline and at follow-up using real-time quantitative polymerase chain reaction. Physical performance was evaluated only at follow-up using the Senior Fitness Test (SFT), which assesses strength, flexibility and endurance. In women, shorter telomere length at follow-up (p = 0.044) and greater telomere attrition during follow-up time (p = 0.022) were associated with poorer physical performance after adjusting for covariates (age at baseline, smoking status, body mass index at baseline, follow-up time and educational attainment). No similar associations were found for men. This indicates that, at least in women, telomere length could potentially be used as a biomarker for physical performance, however, more longitudinal studies are needed to confirm this association.

KW - 3142 Public health care science, environmental and occupational health

KW - Biomarkers

KW - Physical function

KW - Aging

KW - Epidemiology

U2 - 10.1016/j.mad.2019.111145

DO - 10.1016/j.mad.2019.111145

M3 - Article

VL - 183

JO - Mechanisms of Ageing and Development

JF - Mechanisms of Ageing and Development

SN - 0047-6374

M1 - 111145

ER -