The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia

Ralda Nehme; Olli Pietiläinen; Mykyta Artomov; Matthew Tegtmeyer; Vera Valakh; Leevi Lehtonen; Christina Bell; Tarjinder Singh; Aditi Trehan; John Sherwood; Danielle Manning; Emily Peirent; Rhea Malik; Ellen J. Guss; Derek Hawes; Amanda Beccard; Anne M. Bara; Dane Z. Hazelbaker; Emanuela Zuccaro; Giulio Genovese; Alexander A. Loboda; Anna Neumann; Christina Lilliehook; Outi Kuismin; Eija Hamalainen; Mitja Kurki; Christina M. Hultman; Anna K. Kahler; Joao A. Paulo; Andrea Ganna; Jon Madison; Bruce Cohen; Donna McPhie; Rolf Adolfsson; Roy Perlis; Ricardo Dolmetsch; Samouil Farhi; Steven McCarroll; Steven Hyman; Ben Neale; Lindy E. Barrett; Wade Harper; Aarno Palotie; Mark Daly; Kevin Eggan

doi:10.1038/s41467-022-31436-8

The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia

Ralda Nehme, Olli Pietiläinen, Mykyta Artomov, Matthew Tegtmeyer, Vera Valakh, Leevi Lehtonen, Christina Bell, Tarjinder Singh, Aditi Trehan, John Sherwood, Danielle Manning, Emily Peirent, Rhea Malik, Ellen J. Guss, Derek Hawes, Amanda Beccard, Anne M. Bara, Dane Z. Hazelbaker, Emanuela Zuccaro, Giulio GenoveseAlexander A. Loboda, Anna Neumann, Christina Lilliehook, Outi Kuismin, Eija Hamalainen, Mitja Kurki, Christina M. Hultman, Anna K. Kahler, Joao A. Paulo, Andrea Ganna, Jon Madison, Bruce Cohen, Donna McPhie, Rolf Adolfsson, Roy Perlis, Ricardo Dolmetsch, Samouil Farhi, Steven McCarroll, Steven Hyman, Ben Neale, Lindy E. Barrett, Wade Harper, Aarno Palotie, Mark Daly, Kevin Eggan

Tutkimustuotos: Artikkelijulkaisu › Artikkeli › Tieteellinen › vertaisarvioitu

Alkuperäiskieli	englanti
Artikkeli	3690
Lehti	Nature Communications
Vuosikerta	13
Numero	1
Sivumäärä	21
ISSN	2041-1723
DOI - pysyväislinkit	https://doi.org/10.1038/s41467-022-31436-8
Tila	Julkaistu - 27 kesäk. 2022
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

3111 Biolääketieteet
3112 Neurotieteet
1184 Genetiikka, kehitysbiologia, fysiologia

Pääsy asiakirjaan

10.1038/s41467-022-31436-8

s41467-022-31436-8Lopullinen julkaistu versio, 4,39 MBLisenssi: CC BY

Siteeraa tätä

Nehme, R., Pietiläinen, O., Artomov, M., Tegtmeyer, M., Valakh, V., Lehtonen, L., Bell, C., Singh, T., Trehan, A., Sherwood, J., Manning, D., Peirent, E., Malik, R., Guss, E. J., Hawes, D., Beccard, A., Bara, A. M., Hazelbaker, D. Z., Zuccaro, E., ... Eggan, K. (2022). The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia. Nature Communications, 13(1), Artikkeli 3690. https://doi.org/10.1038/s41467-022-31436-8

@article{8b60ced3ee254e7a97a7a0503b889ec5,

title = "The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia",

keywords = "DELETION SYNDROME, PSYCHIATRIC-DISORDERS, MOUSE MODEL, AUTISM SPECTRUM, RISK, BRAIN, INDIVIDUALS, EXPRESSION, MUTATIONS, VARIANTS, 3111 Biomedicine, 3112 Neurosciences, 1184 Genetics, developmental biology, physiology",

author = "Ralda Nehme and Olli Pietil{\"a}inen and Mykyta Artomov and Matthew Tegtmeyer and Vera Valakh and Leevi Lehtonen and Christina Bell and Tarjinder Singh and Aditi Trehan and John Sherwood and Danielle Manning and Emily Peirent and Rhea Malik and Guss, {Ellen J.} and Derek Hawes and Amanda Beccard and Bara, {Anne M.} and Hazelbaker, {Dane Z.} and Emanuela Zuccaro and Giulio Genovese and Loboda, {Alexander A.} and Anna Neumann and Christina Lilliehook and Outi Kuismin and Eija Hamalainen and Mitja Kurki and Hultman, {Christina M.} and Kahler, {Anna K.} and Paulo, {Joao A.} and Andrea Ganna and Jon Madison and Bruce Cohen and Donna McPhie and Rolf Adolfsson and Roy Perlis and Ricardo Dolmetsch and Samouil Farhi and Steven McCarroll and Steven Hyman and Ben Neale and Barrett, {Lindy E.} and Wade Harper and Aarno Palotie and Mark Daly and Kevin Eggan",

year = "2022",

month = jun,

day = "27",

doi = "10.1038/s41467-022-31436-8",

language = "English",

volume = "13",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Publishing Group",

number = "1",

}

Nehme, R, Pietiläinen, O, Artomov, M, Tegtmeyer, M, Valakh, V, Lehtonen, L, Bell, C, Singh, T, Trehan, A, Sherwood, J, Manning, D, Peirent, E, Malik, R, Guss, EJ, Hawes, D, Beccard, A, Bara, AM, Hazelbaker, DZ, Zuccaro, E, Genovese, G, Loboda, AA, Neumann, A, Lilliehook, C, Kuismin, O, Hamalainen, E, Kurki, M, Hultman, CM, Kahler, AK, Paulo, JA, Ganna, A, Madison, J, Cohen, B, McPhie, D, Adolfsson, R, Perlis, R, Dolmetsch, R, Farhi, S, McCarroll, S, Hyman, S, Neale, B, Barrett, LE, Harper, W, Palotie, A , Daly, M & Eggan, K 2022, 'The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia', Nature Communications, Vuosikerta 13, Nro 1, 3690. https://doi.org/10.1038/s41467-022-31436-8

TY - JOUR

T1 - The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia

AU - Nehme, Ralda

AU - Pietiläinen, Olli

AU - Artomov, Mykyta

AU - Tegtmeyer, Matthew

AU - Valakh, Vera

AU - Lehtonen, Leevi

AU - Bell, Christina

AU - Singh, Tarjinder

AU - Trehan, Aditi

AU - Sherwood, John

AU - Manning, Danielle

AU - Peirent, Emily

AU - Malik, Rhea

AU - Guss, Ellen J.

AU - Hawes, Derek

AU - Beccard, Amanda

AU - Bara, Anne M.

AU - Hazelbaker, Dane Z.

AU - Zuccaro, Emanuela

AU - Genovese, Giulio

AU - Loboda, Alexander A.

AU - Neumann, Anna

AU - Lilliehook, Christina

AU - Kuismin, Outi

AU - Hamalainen, Eija

AU - Kurki, Mitja

AU - Hultman, Christina M.

AU - Kahler, Anna K.

AU - Paulo, Joao A.

AU - Ganna, Andrea

AU - Madison, Jon

AU - Cohen, Bruce

AU - McPhie, Donna

AU - Adolfsson, Rolf

AU - Perlis, Roy

AU - Dolmetsch, Ricardo

AU - Farhi, Samouil

AU - McCarroll, Steven

AU - Hyman, Steven

AU - Neale, Ben

AU - Barrett, Lindy E.

AU - Harper, Wade

AU - Palotie, Aarno

AU - Daly, Mark

AU - Eggan, Kevin

PY - 2022/6/27

Y1 - 2022/6/27

KW - DELETION SYNDROME

KW - PSYCHIATRIC-DISORDERS

KW - MOUSE MODEL

KW - AUTISM SPECTRUM

KW - RISK

KW - BRAIN

KW - INDIVIDUALS

KW - EXPRESSION

KW - MUTATIONS

KW - VARIANTS

KW - 3111 Biomedicine

KW - 3112 Neurosciences

KW - 1184 Genetics, developmental biology, physiology

U2 - 10.1038/s41467-022-31436-8

DO - 10.1038/s41467-022-31436-8

M3 - Article

SN - 2041-1723

VL - 13

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 3690

ER -