The azulene scaffold from a medicinal chemist's perspective: Physicochemical and in vitro parameters relevant for drug discovery

Teppo Leino, Peter Sieger, Jari Yli-Kauhaluoma, Erik A. A. Wallén, Jörg T. Kley

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Abstrakti

Azulene is a bicyclic scaffold rarely applied in medicinal chemistry. Here we report physicochemical and in vitro parameters relevant for drug discovery for a series of diversely substituted azulenes. We syn-thesized and characterized several scaffold hopping series of analogously substituted azulenes, indoles and naphthalenes. This enabled a comparison of azulene with the more common scaffolds indole and naphthalene. Our data indicates that undesirably low photostability of azulenes is restricted to certain substitution patterns. Generally, we conclude that azulene is an underused lipophilic bicycle and should be considered as a valuable complement to the collection of medicinal chemistry scaffolds. (c) 2022 The Authors. Published by Elsevier Masson SAS.

Alkuperäiskielienglanti
Artikkeli114374
LehtiEuropean Journal of Medicinal Chemistry
Vuosikerta237
Sivumäärä12
ISSN0223-5234
DOI - pysyväislinkit
TilaJulkaistu - 5 heinäk. 2022
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

  • 317 Farmasia

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