The Cre/Lox System to Assess the Development of the Mouse Brain

Claudius Frank Kratochwil, Filippo M. Rijli

Tutkimustuotos: Artikkeli kirjassa/raportissa/konferenssijulkaisussaKirjan luku tai artikkeliTieteellinen

Abstrakti

Cre-mediated recombination has become a powerful tool to confine gene deletions (conditional knockouts) or overexpression of genes (conditional knockin/overexpression). By spatiotemporal restriction of genetic manipulations, major problems of classical knockouts such as embryonic lethality or pleiotropy can be circumvented. Furthermore, Cre-mediated recombination has broad applications in the analysis of the cellular behavior of subpopulations and cell types as well as for genetic fate mapping. This chapter gives an overview about applications for the Cre/LoxP system and their execution.
Alkuperäiskielienglanti
OtsikkoBrain Development: Methods in Molecular Biology : Methods in Molecular Biology
ToimittajatSimon Sprecher
Vuosikerta2047
JulkaisupaikkaNew York, NY
KustantajaHumana press
Julkaisupäivä2020
ISBN (painettu)978-1-4939-9731-2
ISBN (elektroninen)978-1-4939-9732-9
TilaJulkaistu - 2020
OKM-julkaisutyyppiB2 Kirjan tai muun kokoomateoksen osa

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