The Effect of Dividing Walls, a Tunnel, and Restricted Feeding on Cardiovascular Responses to Cage Change and Gavage in Rats (Rattus norvegicus)

Niina Kemppinen, Anna Sofia Meller, Kari Mauranen, Tarja Kohila, Timo Olavi Nevalainen

    Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

    Kuvaus

    Cage change and gavage are routine procedures in animal facilities, yet little is known about whether housing modifications change responses to these procedures. Telemetric activity and cardiovascular parameters were assessed in this experiment. BN and F344 male rats were housed in open or individually ventilated cages, each containing 3 rats, 1 of which had a transponder. A crossover design was used, in which 2 groups were given dividers made of 2 intersecting boards (1 form contained holes loaded with food pellets; the other did not) and 1 group was given a rectangular tunnel. On day 8 of each 2-wk period, the cages were changed; on day 11, rats were gavaged. The parameters were evaluated for the first hour and for the following 17 h. Baseline values for each rat were subtracted from the corresponding response values. The presence of objects did not affect the responses of F344 rats to cage changing or gavage. In BN rats with IVCs, the presence of the plain divider modified the response to both procedures. Responses to procedures appeared to be dependent on both the strain and the cage object, thus complicating the establishment of valid general recommendations.
    Alkuperäiskielienglanti
    LehtiJournal of the American Association for Laboratory Animal Science
    Vuosikerta48
    Numero2
    Sivut157-165
    Sivumäärä9
    ISSN1559-6109
    TilaJulkaistu - 2009
    OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

    Tieteenalat

    • 118 Biotieteet

    Lainaa tätä

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    title = "The Effect of Dividing Walls, a Tunnel, and Restricted Feeding on Cardiovascular Responses to Cage Change and Gavage in Rats (Rattus norvegicus)",
    abstract = "Cage change and gavage are routine procedures in animal facilities, yet little is known about whether housing modifications change responses to these procedures. Telemetric activity and cardiovascular parameters were assessed in this experiment. BN and F344 male rats were housed in open or individually ventilated cages, each containing 3 rats, 1 of which had a transponder. A crossover design was used, in which 2 groups were given dividers made of 2 intersecting boards (1 form contained holes loaded with food pellets; the other did not) and 1 group was given a rectangular tunnel. On day 8 of each 2-wk period, the cages were changed; on day 11, rats were gavaged. The parameters were evaluated for the first hour and for the following 17 h. Baseline values for each rat were subtracted from the corresponding response values. The presence of objects did not affect the responses of F344 rats to cage changing or gavage. In BN rats with IVCs, the presence of the plain divider modified the response to both procedures. Responses to procedures appeared to be dependent on both the strain and the cage object, thus complicating the establishment of valid general recommendations.",
    keywords = "118 Biological sciences",
    author = "Niina Kemppinen and Meller, {Anna Sofia} and Kari Mauranen and Tarja Kohila and Nevalainen, {Timo Olavi}",
    year = "2009",
    language = "English",
    volume = "48",
    pages = "157--165",
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    The Effect of Dividing Walls, a Tunnel, and Restricted Feeding on Cardiovascular Responses to Cage Change and Gavage in Rats (Rattus norvegicus). / Kemppinen, Niina; Meller, Anna Sofia; Mauranen, Kari; Kohila, Tarja; Nevalainen, Timo Olavi.

    julkaisussa: Journal of the American Association for Laboratory Animal Science, Vuosikerta 48, Nro 2, 2009, s. 157-165.

    Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

    TY - JOUR

    T1 - The Effect of Dividing Walls, a Tunnel, and Restricted Feeding on Cardiovascular Responses to Cage Change and Gavage in Rats (Rattus norvegicus)

    AU - Kemppinen, Niina

    AU - Meller, Anna Sofia

    AU - Mauranen, Kari

    AU - Kohila, Tarja

    AU - Nevalainen, Timo Olavi

    PY - 2009

    Y1 - 2009

    N2 - Cage change and gavage are routine procedures in animal facilities, yet little is known about whether housing modifications change responses to these procedures. Telemetric activity and cardiovascular parameters were assessed in this experiment. BN and F344 male rats were housed in open or individually ventilated cages, each containing 3 rats, 1 of which had a transponder. A crossover design was used, in which 2 groups were given dividers made of 2 intersecting boards (1 form contained holes loaded with food pellets; the other did not) and 1 group was given a rectangular tunnel. On day 8 of each 2-wk period, the cages were changed; on day 11, rats were gavaged. The parameters were evaluated for the first hour and for the following 17 h. Baseline values for each rat were subtracted from the corresponding response values. The presence of objects did not affect the responses of F344 rats to cage changing or gavage. In BN rats with IVCs, the presence of the plain divider modified the response to both procedures. Responses to procedures appeared to be dependent on both the strain and the cage object, thus complicating the establishment of valid general recommendations.

    AB - Cage change and gavage are routine procedures in animal facilities, yet little is known about whether housing modifications change responses to these procedures. Telemetric activity and cardiovascular parameters were assessed in this experiment. BN and F344 male rats were housed in open or individually ventilated cages, each containing 3 rats, 1 of which had a transponder. A crossover design was used, in which 2 groups were given dividers made of 2 intersecting boards (1 form contained holes loaded with food pellets; the other did not) and 1 group was given a rectangular tunnel. On day 8 of each 2-wk period, the cages were changed; on day 11, rats were gavaged. The parameters were evaluated for the first hour and for the following 17 h. Baseline values for each rat were subtracted from the corresponding response values. The presence of objects did not affect the responses of F344 rats to cage changing or gavage. In BN rats with IVCs, the presence of the plain divider modified the response to both procedures. Responses to procedures appeared to be dependent on both the strain and the cage object, thus complicating the establishment of valid general recommendations.

    KW - 118 Biological sciences

    M3 - Article

    VL - 48

    SP - 157

    EP - 165

    JO - Journal of the American Association for Laboratory Animal Science

    JF - Journal of the American Association for Laboratory Animal Science

    SN - 1559-6109

    IS - 2

    ER -