The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy

Tommi P. Kilpeläinen; Laura Hellinen; Johannes Vrijdag; Xu Yan; Reinis Svarcbahs; Kati-Sisko Vellonen; Anne-Marie Lambeir; Henri Huttunen; Arto Urtti; Erik A. A. Wallen; Timo T. Myohanen

doi:10.1016/j.biopha.2020.110253

The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy

Tommi P. Kilpeläinen, Laura Hellinen, Johannes Vrijdag, Xu Yan, Reinis Svarcbahs, Kati-Sisko Vellonen, Anne-Marie Lambeir, Henri Huttunen, Arto Urtti, Erik A. A. Wallen, Timo T. Myohanen

Tutkimustuotos: Artikkelijulkaisu › Artikkeli › Tieteellinen › vertaisarvioitu

Alkuperäiskieli	englanti
Artikkeli	110253
Lehti	Biomedicine & Pharmacotherapy
Vuosikerta	128
Sivumäärä	10
ISSN	0753-3322
DOI - pysyväislinkit	https://doi.org/10.1016/j.biopha.2020.110253
Tila	Julkaistu - elok. 2020
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

317 Farmasia

Pääsy asiakirjaan

10.1016/j.biopha.2020.110253

1-s2.0-S0753332220304455-mainLopullinen julkaistu versio, 1,14 MBLisenssi: CC BY

Siteeraa tätä

Kilpeläinen, T. P., Hellinen, L., Vrijdag, J., Yan, X., Svarcbahs, R., Vellonen, K-S., Lambeir, A-M., Huttunen, H., Urtti, A., Wallen, E. A. A., & Myohanen, T. T. (2020). The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy. Biomedicine & Pharmacotherapy, 128, [110253]. https://doi.org/10.1016/j.biopha.2020.110253

@article{932c6bbd839d49a9801f9283249af904,

title = "The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy",

keywords = "Serine protease, Alpha-Synuclein, Autophagy, Parkinson's disease, Protein conformation, ACTIVE-SITE, CELL, KYP-2047, PROTEIN, BRAIN, ENDOPEPTIDASE, PROLINE, 317 Pharmacy",

author = "Kilpel{\"a}inen, {Tommi P.} and Laura Hellinen and Johannes Vrijdag and Xu Yan and Reinis Svarcbahs and Kati-Sisko Vellonen and Anne-Marie Lambeir and Henri Huttunen and Arto Urtti and Wallen, {Erik A. A.} and Myohanen, {Timo T.}",

year = "2020",

month = aug,

doi = "10.1016/j.biopha.2020.110253",

language = "English",

volume = "128",

journal = "Biomedicine & Pharmacotherapy",

issn = "0753-3322",

publisher = "ELSEVIER FRANCE",

}

Kilpeläinen, TP, Hellinen, L, Vrijdag, J, Yan, X, Svarcbahs, R, Vellonen, K-S, Lambeir, A-M, Huttunen, H , Urtti, A , Wallen, EAA & Myohanen, TT 2020, 'The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy', Biomedicine & Pharmacotherapy, Vuosikerta 128, 110253. https://doi.org/10.1016/j.biopha.2020.110253

The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy. / Kilpeläinen, Tommi P.; Hellinen, Laura; Vrijdag, Johannes et al.

julkaisussa: Biomedicine & Pharmacotherapy, Vuosikerta 128, 110253, 08.2020.

Tutkimustuotos: Artikkelijulkaisu › Artikkeli › Tieteellinen › vertaisarvioitu

TY - JOUR

T1 - The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy

AU - Kilpeläinen, Tommi P.

AU - Hellinen, Laura

AU - Vrijdag, Johannes

AU - Yan, Xu

AU - Svarcbahs, Reinis

AU - Vellonen, Kati-Sisko

AU - Lambeir, Anne-Marie

AU - Huttunen, Henri

AU - Urtti, Arto

AU - Wallen, Erik A. A.

AU - Myohanen, Timo T.

PY - 2020/8

Y1 - 2020/8

KW - Serine protease

KW - Alpha-Synuclein

KW - Autophagy

KW - Parkinson's disease

KW - Protein conformation

KW - ACTIVE-SITE

KW - CELL

KW - KYP-2047

KW - PROTEIN

KW - BRAIN

KW - ENDOPEPTIDASE

KW - PROLINE

KW - 317 Pharmacy

U2 - 10.1016/j.biopha.2020.110253

DO - 10.1016/j.biopha.2020.110253

M3 - Article

VL - 128

JO - Biomedicine & Pharmacotherapy

JF - Biomedicine & Pharmacotherapy

SN - 0753-3322

M1 - 110253

ER -