Abstrakti

Background
Despite the importance of immune checkpoints in immunotherapy, the prognostic value of these molecules remains controversial in oral squamous cell carcinoma (OSCC). We performed a systematic review to investigate the prognostic significance of the immune checkpoints in OSCC.

Materials
A systematic search was conducted in Ovid Medline, Scopus and Cochrane libraries, and all studies that evaluated the prognostic significance of immune checkpoints in OSCC were systematically retrieved.

Results
Twelve immune checkpoints/modulators were studied for their prognostic values in OSCC patients between 1985 and 2017. Seven immune checkpoints (FKBP51, B7‐H4, B7‐H6, ALHD1, PD‐L1, B7‐H3 and IDO1) were reported to be associated with poor patients’ survival in at least one study, and five (CTLA‐4, TLT‐2, VISTA, PD‐L2 and PD‐1) did not have a significant prognostic value. PD‐L1 results were controversial as it was reported to be associated with both better and worse patients’ survival.

Conclusions
Even though immune checkpoint markers had high expectation for OSCC prognostication, our systematic review revealed that the majority of them had been studied only once. The other molecules, which had been studied more than once, had controversial findings, except B7‐H3.
Alkuperäiskielisuomi
LehtiJournal of Oral Pathology & Medicine
Vuosikerta25
Numero6
Sivut1435-1445
Sivumäärä10
ISSN0904-2512
DOI - pysyväislinkit
TilaJulkaistu - 13 lokakuuta 2018
OKM-julkaisutyyppiA2 Katsausartikkeli tieteellisessä aikakauslehdessä

Tieteenalat

  • 313 Hammaslääketieteet
  • B7‐H3
  • immune checkpoint
  • oral squamous cell carcinoma
  • prognosis
  • programmed death‐ ligand 1 (PD‐L1)
  • systematic review

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