The role of oxytocinergic genes in the intergenerational transmission of parent-child relationship qualities

Kateryna Savelieva, Mirka Hintsanen, Henrik Dobewall, Markus Jokela, Laura Pulkki-Råback, Marko Elovainio, Ilkka Seppälä, Tero Lehtimäki, Olli Raitakari, Liisa Keltikangas-Järvinen

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Kuvaus

Parenting qualities are known to transmit across generations, but less is known about genetic processes that may modify how strongly parenting quality carries across generations. We examined in prospective data whether oxytocinergic genes of offspring moderate the intergenerational transmission of warm and accepting parent-child relationship qualities. The sample comprised 1167 Finnish parents (G2, 62% female) and their mothers (G1). At the study baseline, G1 mothers (Mage = 38) reported parent-child relationship qualities towards G2 children (age range 3-18). After 28-34 years, G2 offspring reported parent-child relationship qualities towards their own children using the same questionnaire. A cumulative genetic score was computed for G2 by summing up previously identified four alleles associated with non-optimal parenting or social impairments across OXTR (rs1042778, rs2254298, rs53576) and CD38 (rs3796863) genes. Results indicated no interaction effects of G2 cumulative genetic score on the transmission of parent-child relationship qualities. Among single polymorphisms in OXTR, the interaction effects of rs53576 and rs1042778 were found. G1 maternal emotional warmth was associated with higher G2 emotional warmth among G2 participants with the OXTR rs53576 AA/AG genotype, but not among those with the GG genotype. G1 maternal acceptance was associated with higher G2 acceptance among those G2 participants with the OXTR rs1042778 GG/GT genotype, but not among those with the TT genotype. Oxytocinergic genes may influence sensitivity to quality of parent-child relationship, although this needs replication in future studies.

Alkuperäiskielienglanti
Artikkeli104540
LehtiHormones and Behavior
Vuosikerta114
Sivumäärä8
ISSN0018-506X
DOI - pysyväislinkit
TilaJulkaistu - elokuuta 2019
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

  • 515 Psykologia

Lainaa tätä

@article{e1a5d57fe1d84b72a023abcf1cb39711,
title = "The role of oxytocinergic genes in the intergenerational transmission of parent-child relationship qualities",
abstract = "Parenting qualities are known to transmit across generations, but less is known about genetic processes that may modify how strongly parenting quality carries across generations. We examined in prospective data whether oxytocinergic genes of offspring moderate the intergenerational transmission of warm and accepting parent-child relationship qualities. The sample comprised 1167 Finnish parents (G2, 62{\%} female) and their mothers (G1). At the study baseline, G1 mothers (Mage = 38) reported parent-child relationship qualities towards G2 children (age range 3-18). After 28-34 years, G2 offspring reported parent-child relationship qualities towards their own children using the same questionnaire. A cumulative genetic score was computed for G2 by summing up previously identified four alleles associated with non-optimal parenting or social impairments across OXTR (rs1042778, rs2254298, rs53576) and CD38 (rs3796863) genes. Results indicated no interaction effects of G2 cumulative genetic score on the transmission of parent-child relationship qualities. Among single polymorphisms in OXTR, the interaction effects of rs53576 and rs1042778 were found. G1 maternal emotional warmth was associated with higher G2 emotional warmth among G2 participants with the OXTR rs53576 AA/AG genotype, but not among those with the GG genotype. G1 maternal acceptance was associated with higher G2 acceptance among those G2 participants with the OXTR rs1042778 GG/GT genotype, but not among those with the TT genotype. Oxytocinergic genes may influence sensitivity to quality of parent-child relationship, although this needs replication in future studies.",
keywords = "AFFILIATION, Acceptance, BEHAVIOR, CD38 gene, DIFFERENTIAL-SUSCEPTIBILITY, ENVIRONMENT INTERACTION RESEARCH, Gene-environment (GxE) interaction, INDIVIDUAL-DIFFERENCES, Intergenerational transmission, Oxytocin receptor gene (OXTR), Parent-child relationship qualities, RISK, Warmth, 515 Psychology",
author = "Kateryna Savelieva and Mirka Hintsanen and Henrik Dobewall and Markus Jokela and Laura Pulkki-R{\aa}back and Marko Elovainio and Ilkka Sepp{\"a}l{\"a} and Tero Lehtim{\"a}ki and Olli Raitakari and Liisa Keltikangas-J{\"a}rvinen",
year = "2019",
month = "8",
doi = "10.1016/j.yhbeh.2019.06.004",
language = "English",
volume = "114",
journal = "Hormones and Behavior",
issn = "0018-506X",
publisher = "Elsevier Scientific Publ. Co",

}

The role of oxytocinergic genes in the intergenerational transmission of parent-child relationship qualities. / Savelieva, Kateryna; Hintsanen, Mirka; Dobewall, Henrik; Jokela, Markus; Pulkki-Råback, Laura; Elovainio, Marko; Seppälä, Ilkka; Lehtimäki, Tero; Raitakari, Olli; Keltikangas-Järvinen, Liisa.

julkaisussa: Hormones and Behavior, Vuosikerta 114, 104540, 08.2019.

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

TY - JOUR

T1 - The role of oxytocinergic genes in the intergenerational transmission of parent-child relationship qualities

AU - Savelieva, Kateryna

AU - Hintsanen, Mirka

AU - Dobewall, Henrik

AU - Jokela, Markus

AU - Pulkki-Råback, Laura

AU - Elovainio, Marko

AU - Seppälä, Ilkka

AU - Lehtimäki, Tero

AU - Raitakari, Olli

AU - Keltikangas-Järvinen, Liisa

PY - 2019/8

Y1 - 2019/8

N2 - Parenting qualities are known to transmit across generations, but less is known about genetic processes that may modify how strongly parenting quality carries across generations. We examined in prospective data whether oxytocinergic genes of offspring moderate the intergenerational transmission of warm and accepting parent-child relationship qualities. The sample comprised 1167 Finnish parents (G2, 62% female) and their mothers (G1). At the study baseline, G1 mothers (Mage = 38) reported parent-child relationship qualities towards G2 children (age range 3-18). After 28-34 years, G2 offspring reported parent-child relationship qualities towards their own children using the same questionnaire. A cumulative genetic score was computed for G2 by summing up previously identified four alleles associated with non-optimal parenting or social impairments across OXTR (rs1042778, rs2254298, rs53576) and CD38 (rs3796863) genes. Results indicated no interaction effects of G2 cumulative genetic score on the transmission of parent-child relationship qualities. Among single polymorphisms in OXTR, the interaction effects of rs53576 and rs1042778 were found. G1 maternal emotional warmth was associated with higher G2 emotional warmth among G2 participants with the OXTR rs53576 AA/AG genotype, but not among those with the GG genotype. G1 maternal acceptance was associated with higher G2 acceptance among those G2 participants with the OXTR rs1042778 GG/GT genotype, but not among those with the TT genotype. Oxytocinergic genes may influence sensitivity to quality of parent-child relationship, although this needs replication in future studies.

AB - Parenting qualities are known to transmit across generations, but less is known about genetic processes that may modify how strongly parenting quality carries across generations. We examined in prospective data whether oxytocinergic genes of offspring moderate the intergenerational transmission of warm and accepting parent-child relationship qualities. The sample comprised 1167 Finnish parents (G2, 62% female) and their mothers (G1). At the study baseline, G1 mothers (Mage = 38) reported parent-child relationship qualities towards G2 children (age range 3-18). After 28-34 years, G2 offspring reported parent-child relationship qualities towards their own children using the same questionnaire. A cumulative genetic score was computed for G2 by summing up previously identified four alleles associated with non-optimal parenting or social impairments across OXTR (rs1042778, rs2254298, rs53576) and CD38 (rs3796863) genes. Results indicated no interaction effects of G2 cumulative genetic score on the transmission of parent-child relationship qualities. Among single polymorphisms in OXTR, the interaction effects of rs53576 and rs1042778 were found. G1 maternal emotional warmth was associated with higher G2 emotional warmth among G2 participants with the OXTR rs53576 AA/AG genotype, but not among those with the GG genotype. G1 maternal acceptance was associated with higher G2 acceptance among those G2 participants with the OXTR rs1042778 GG/GT genotype, but not among those with the TT genotype. Oxytocinergic genes may influence sensitivity to quality of parent-child relationship, although this needs replication in future studies.

KW - AFFILIATION

KW - Acceptance

KW - BEHAVIOR

KW - CD38 gene

KW - DIFFERENTIAL-SUSCEPTIBILITY

KW - ENVIRONMENT INTERACTION RESEARCH

KW - Gene-environment (GxE) interaction

KW - INDIVIDUAL-DIFFERENCES

KW - Intergenerational transmission

KW - Oxytocin receptor gene (OXTR)

KW - Parent-child relationship qualities

KW - RISK

KW - Warmth

KW - 515 Psychology

U2 - 10.1016/j.yhbeh.2019.06.004

DO - 10.1016/j.yhbeh.2019.06.004

M3 - Article

VL - 114

JO - Hormones and Behavior

JF - Hormones and Behavior

SN - 0018-506X

M1 - 104540

ER -