Therapeutic potential and metabolic impact of alternative respiratory chain enzymes

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Abstrakti

The alternative enzymes of the respiratory chain, which are found in all the kingdoms of life, except for vertebrates, have received great interest for the treatment of disorders related to mitochondrial dysfunction. These enzymes have recently been used in cellular and animal models to understand and mitigate pathologies from mitochondrial diseases to Parkinson’s disease and cancer. The functional properties of these alternative enzymes have also helped to answer fundamental questions about the role of the respiratory chain in maintaining cellular and tissue metabolism. At the same time, the compatibility of these enzymes with mammalian metabolism has been widely characterized, and rejected on specific occasions. Although many questions remain to be answered regarding the metabolic impact of the alternative enzymes of the respiratory chain in humans, their potential as a therapeutic and research tool is starting to unravel.

Alkuperäiskielienglanti
OtsikkoMolecular Nutrition and Mitochondria : Metabolic Deficits, Whole-Diet Interventions, and Targeted Nutraceuticals
ToimittajatSergej M. Ostojic
Sivumäärä23
JulkaisupaikkaAmsterdam
KustantajaElsevier
Julkaisupäivä2023
Sivut105-127
Artikkeli no4
ISBN (painettu)978-0-323-90256-4
ISBN (elektroninen)978-0-323-98452-2
DOI - pysyväislinkit
TilaJulkaistu - 2023
OKM-julkaisutyyppiA3 Kirjan tai muun kokoomateoksen osa

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