Kuvaus

Tick-borne encephalitis virus (TBEV) is a growing health concern. It causes a severe disease that can lead to permanent neurological complications or death and the incidence of TBEV infections is constantly rising. Our understanding of TBEV’s structure lags behind that of other flaviviruses, but has advanced recently with the publication of a high-resolution structure of the TBEV virion. The gaps in our knowledge include: aspects of receptor binding, replication and virus assembly. Furthermore, TBEV has mostly been studied in mammalian systems, even though the virus’ interaction with its tick hosts is a central part of its life cycle. Elucidating these aspects of TBEV biology are crucial for the development of TBEV antivirals, as well as the improvement of diagnostics. In this review, we summarise the current structural knowledge on TBEV, bringing attention to the current gaps in our understanding, and propose further research that is needed to truly understand the structural-functional relationship of the virus and its hosts.
Alkuperäiskielienglanti
Artikkeli350
LehtiViruses
Vuosikerta10
Numero7
Sivumäärä20
ISSN1999-4915
DOI - pysyväislinkit
TilaJulkaistu - 28 kesäkuuta 2018
OKM-julkaisutyyppiA2 Katsausartikkeli tieteellisessä aikakauslehdessä

Tieteenalat

  • 1183 Kasvibiologia, mikrobiologia, virologia

Lainaa tätä

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title = "Tick-Borne Encephalitis Virus: A Structural View",
abstract = "Tick-borne encephalitis virus (TBEV) is a growing health concern. It causes a severe disease that can lead to permanent neurological complications or death and the incidence of TBEV infections is constantly rising. Our understanding of TBEV’s structure lags behind that of other flaviviruses, but has advanced recently with the publication of a high-resolution structure of the TBEV virion. The gaps in our knowledge include: aspects of receptor binding, replication and virus assembly. Furthermore, TBEV has mostly been studied in mammalian systems, even though the virus’ interaction with its tick hosts is a central part of its life cycle. Elucidating these aspects of TBEV biology are crucial for the development of TBEV antivirals, as well as the improvement of diagnostics. In this review, we summarise the current structural knowledge on TBEV, bringing attention to the current gaps in our understanding, and propose further research that is needed to truly understand the structural-functional relationship of the virus and its hosts.",
keywords = "1183 Plant biology, microbiology, virology, tick-borne encephalitis virus, TBEV, flavivirus structure, envelope protein, M protein, E protein, prM, nucleocapsid, virus assembly, maturation, WEST-NILE-VIRUS, LAMININ-BINDING PROTEIN, RECOMBINANT SUBVIRAL PARTICLES, FLAVIVIRUS MEMBRANE-FUSION, NUCLEOLAR HELICASE DDX56, DENGUE VIRUS, CAPSID PROTEIN, ENVELOPE PROTEIN, FEVER VIRUS, HEPARAN-SULFATE",
author = "Pulkkinen, {Lauri I. A.} and Butcher, {Sarah J.} and Maria Anastasina",
year = "2018",
month = "6",
day = "28",
doi = "10.3390/v10070350",
language = "English",
volume = "10",
journal = "Viruses",
issn = "1999-4915",
publisher = "MDPI",
number = "7",

}

Tick-Borne Encephalitis Virus: A Structural View. / Pulkkinen, Lauri I. A.; Butcher, Sarah J.; Anastasina, Maria.

julkaisussa: Viruses, Vuosikerta 10, Nro 7, 350, 28.06.2018.

Tutkimustuotos: ArtikkelijulkaisuKatsausartikkeliTieteellinenvertaisarvioitu

TY - JOUR

T1 - Tick-Borne Encephalitis Virus: A Structural View

AU - Pulkkinen, Lauri I. A.

AU - Butcher, Sarah J.

AU - Anastasina, Maria

PY - 2018/6/28

Y1 - 2018/6/28

N2 - Tick-borne encephalitis virus (TBEV) is a growing health concern. It causes a severe disease that can lead to permanent neurological complications or death and the incidence of TBEV infections is constantly rising. Our understanding of TBEV’s structure lags behind that of other flaviviruses, but has advanced recently with the publication of a high-resolution structure of the TBEV virion. The gaps in our knowledge include: aspects of receptor binding, replication and virus assembly. Furthermore, TBEV has mostly been studied in mammalian systems, even though the virus’ interaction with its tick hosts is a central part of its life cycle. Elucidating these aspects of TBEV biology are crucial for the development of TBEV antivirals, as well as the improvement of diagnostics. In this review, we summarise the current structural knowledge on TBEV, bringing attention to the current gaps in our understanding, and propose further research that is needed to truly understand the structural-functional relationship of the virus and its hosts.

AB - Tick-borne encephalitis virus (TBEV) is a growing health concern. It causes a severe disease that can lead to permanent neurological complications or death and the incidence of TBEV infections is constantly rising. Our understanding of TBEV’s structure lags behind that of other flaviviruses, but has advanced recently with the publication of a high-resolution structure of the TBEV virion. The gaps in our knowledge include: aspects of receptor binding, replication and virus assembly. Furthermore, TBEV has mostly been studied in mammalian systems, even though the virus’ interaction with its tick hosts is a central part of its life cycle. Elucidating these aspects of TBEV biology are crucial for the development of TBEV antivirals, as well as the improvement of diagnostics. In this review, we summarise the current structural knowledge on TBEV, bringing attention to the current gaps in our understanding, and propose further research that is needed to truly understand the structural-functional relationship of the virus and its hosts.

KW - 1183 Plant biology, microbiology, virology

KW - tick-borne encephalitis virus

KW - TBEV

KW - flavivirus structure

KW - envelope protein

KW - M protein

KW - E protein

KW - prM

KW - nucleocapsid

KW - virus assembly

KW - maturation

KW - WEST-NILE-VIRUS

KW - LAMININ-BINDING PROTEIN

KW - RECOMBINANT SUBVIRAL PARTICLES

KW - FLAVIVIRUS MEMBRANE-FUSION

KW - NUCLEOLAR HELICASE DDX56

KW - DENGUE VIRUS

KW - CAPSID PROTEIN

KW - ENVELOPE PROTEIN

KW - FEVER VIRUS

KW - HEPARAN-SULFATE

U2 - 10.3390/v10070350

DO - 10.3390/v10070350

M3 - Review Article

VL - 10

JO - Viruses

JF - Viruses

SN - 1999-4915

IS - 7

M1 - 350

ER -