Time-resolved SERS for characterizing extracellular vesicles

T. Rojalin, H. Saari, P. Somersalo, Saara Laitinen, Mikko Turunen, T. Viitala, Sebastian Wachsmann-Hogiu, Zachary J. Smith, M. Yliperttula

Tutkimustuotos: KonferenssimateriaalitPosteriTutkimus

Kuvaus

The aim of this work is to develop a platform for characterizing extracellular vesicles (EV) by using gold-polymer nanopillar SERS arrays simultaneously circumventing the photoluminescence-related disadvantages of Raman with a time-resolved approach. EVs are rich of biochemical information reporting of, for example, diseased state of the biological system. Currently, straightforward, label-free and fast EV characterization methods with low sample consumption are warranted. In this study, SERS spectra of red blood cell and platelet derived EVs were successfully measured and their biochemical contents analyzed using multivariate data analysis techniques. The developed platform could be conveniently used for EV analytics in general. © 2017 SPIE.
Alkuperäiskielienglanti
DOI - pysyväislinkit
TilaJulkaistu - 2017
OKM-julkaisutyyppiEi sovellu
TapahtumaConference of Plasmonics in Biology and Medicine - San Francisco, Yhdysvallat (USA)
Kesto: 28 tammikuuta 20172 helmikuuta 2017
Konferenssinumero: XIV

Konferenssi

KonferenssiConference of Plasmonics in Biology and Medicine
MaaYhdysvallat (USA)
KaupunkiSan Francisco
Ajanjakso28/01/201702/02/2017

Tieteenalat

  • 3121 Sisätaudit
  • 317 Farmasia

Lainaa tätä

Rojalin, T., Saari, H., Somersalo, P., Laitinen, S., Turunen, M., Viitala, T., ... Yliperttula, M. (2017). Time-resolved SERS for characterizing extracellular vesicles. Posterin esittämispaikka: Conference of Plasmonics in Biology and Medicine, San Francisco, Yhdysvallat (USA). https://doi.org/10.1117/12.2271865
Rojalin, T. ; Saari, H. ; Somersalo, P. ; Laitinen, Saara ; Turunen, Mikko ; Viitala, T. ; Wachsmann-Hogiu, Sebastian ; Smith, Zachary J. ; Yliperttula, M. / Time-resolved SERS for characterizing extracellular vesicles. Posterin esittämispaikka: Conference of Plasmonics in Biology and Medicine, San Francisco, Yhdysvallat (USA).
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title = "Time-resolved SERS for characterizing extracellular vesicles",
abstract = "The aim of this work is to develop a platform for characterizing extracellular vesicles (EV) by using gold-polymer nanopillar SERS arrays simultaneously circumventing the photoluminescence-related disadvantages of Raman with a time-resolved approach. EVs are rich of biochemical information reporting of, for example, diseased state of the biological system. Currently, straightforward, label-free and fast EV characterization methods with low sample consumption are warranted. In this study, SERS spectra of red blood cell and platelet derived EVs were successfully measured and their biochemical contents analyzed using multivariate data analysis techniques. The developed platform could be conveniently used for EV analytics in general. {\circledC} 2017 SPIE.",
keywords = "Multivariant analysis, Raman spectroscopy, Biochemical information, Characterization methods, Extracellular, Multivariate data analysis, Red blood cell, Sample consumption, SERS spectrum, Time-resolved, Plasmons, 3121 Internal medicine, 317 Pharmacy",
author = "T. Rojalin and H. Saari and P. Somersalo and Saara Laitinen and Mikko Turunen and T. Viitala and Sebastian Wachsmann-Hogiu and Smith, {Zachary J.} and M. Yliperttula",
year = "2017",
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language = "English",
note = "Conference of Plasmonics in Biology and Medicine ; Conference date: 28-01-2017 Through 02-02-2017",

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Rojalin, T, Saari, H, Somersalo, P, Laitinen, S, Turunen, M, Viitala, T, Wachsmann-Hogiu, S, Smith, ZJ & Yliperttula, M 2017, 'Time-resolved SERS for characterizing extracellular vesicles' Conference of Plasmonics in Biology and Medicine, San Francisco, Yhdysvallat (USA), 28/01/2017 - 02/02/2017, . https://doi.org/10.1117/12.2271865

Time-resolved SERS for characterizing extracellular vesicles. / Rojalin, T.; Saari, H.; Somersalo, P.; Laitinen, Saara; Turunen, Mikko; Viitala, T.; Wachsmann-Hogiu, Sebastian; Smith, Zachary J.; Yliperttula, M.

2017. Posterin esittämispaikka: Conference of Plasmonics in Biology and Medicine, San Francisco, Yhdysvallat (USA).

Tutkimustuotos: KonferenssimateriaalitPosteriTutkimus

TY - CONF

T1 - Time-resolved SERS for characterizing extracellular vesicles

AU - Rojalin, T.

AU - Saari, H.

AU - Somersalo, P.

AU - Laitinen, Saara

AU - Turunen, Mikko

AU - Viitala, T.

AU - Wachsmann-Hogiu, Sebastian

AU - Smith, Zachary J.

AU - Yliperttula, M.

PY - 2017

Y1 - 2017

N2 - The aim of this work is to develop a platform for characterizing extracellular vesicles (EV) by using gold-polymer nanopillar SERS arrays simultaneously circumventing the photoluminescence-related disadvantages of Raman with a time-resolved approach. EVs are rich of biochemical information reporting of, for example, diseased state of the biological system. Currently, straightforward, label-free and fast EV characterization methods with low sample consumption are warranted. In this study, SERS spectra of red blood cell and platelet derived EVs were successfully measured and their biochemical contents analyzed using multivariate data analysis techniques. The developed platform could be conveniently used for EV analytics in general. © 2017 SPIE.

AB - The aim of this work is to develop a platform for characterizing extracellular vesicles (EV) by using gold-polymer nanopillar SERS arrays simultaneously circumventing the photoluminescence-related disadvantages of Raman with a time-resolved approach. EVs are rich of biochemical information reporting of, for example, diseased state of the biological system. Currently, straightforward, label-free and fast EV characterization methods with low sample consumption are warranted. In this study, SERS spectra of red blood cell and platelet derived EVs were successfully measured and their biochemical contents analyzed using multivariate data analysis techniques. The developed platform could be conveniently used for EV analytics in general. © 2017 SPIE.

KW - Multivariant analysis

KW - Raman spectroscopy, Biochemical information

KW - Characterization methods

KW - Extracellular

KW - Multivariate data analysis

KW - Red blood cell

KW - Sample consumption

KW - SERS spectrum

KW - Time-resolved, Plasmons

KW - 3121 Internal medicine

KW - 317 Pharmacy

U2 - 10.1117/12.2271865

DO - 10.1117/12.2271865

M3 - Poster

ER -

Rojalin T, Saari H, Somersalo P, Laitinen S, Turunen M, Viitala T et al. Time-resolved SERS for characterizing extracellular vesicles. 2017. Posterin esittämispaikka: Conference of Plasmonics in Biology and Medicine, San Francisco, Yhdysvallat (USA). https://doi.org/10.1117/12.2271865