Toward high-contrast breast CT at low radiation dose

technical developments

Jani Keyriläinen, Manuel Fernandez, Marja-Liisa Karjalainen-Lindsberg, Pekka Virkkunen, Marjut Leidenius, Karl von Smitten, Petri Sipilä, Stefan Fiedler, Heikki Suhonen, Pekka Suortti, Alberto Bravin

    Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

    Kuvaus

    This study was approved by the local research ethics committee, and patient informed consent was obtained. The purpose of this study was to demonstrate that high-spatial-resolution low-dose analyzer-based x-ray computed tomography (CT) can substantially improve the radiographic contrast of breast tissue in vitro when compared with that attained by using diagnostic mammography and CT. An excised human breast tumor was examined by using analyzer-based x-ray imaging with synchrotron radiation. The correspondence between analyzer-based x-ray images and diagnostic mammograms, CT images, and histopathologic findings was determined. Calcifications and fine details of soft tissue, which are at the contrast detection limit on diagnostic mammograms, are clearly visible on planar analyzer-based x-ray images. Analyzer-based x-ray CT yields high contrast from smoothly varying internal structures, such as tumorous mass lesions, corresponding to information on actual structures seen at histopathologic analysis. The mean glandular dose of 1.9 mGy in analyzer-based x-ray CT is approximately equivalent to the dose administered during single-view screening mammography. The improved visibility of mammo graphically indistinguishable lesions in vitro suggests that analyzer-based x-ray CT may be a valuable method in radiographic evaluation of the breast, thereby justifying further investigations. (c) RSNA, 2008.
    Alkuperäiskielienglanti
    LehtiRadiology
    Vuosikerta249
    Numero1
    Sivut321-327
    Sivumäärä7
    ISSN0033-8419
    DOI - pysyväislinkit
    TilaJulkaistu - 2008
    OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

    Lainaa tätä

    Keyriläinen, J., Fernandez, M., Karjalainen-Lindsberg, M-L., Virkkunen, P., Leidenius, M., Smitten, K. V., ... Bravin, A. (2008). Toward high-contrast breast CT at low radiation dose: technical developments. Radiology, 249(1), 321-327. https://doi.org/10.1148/radiol.2491072129
    Keyriläinen, Jani ; Fernandez, Manuel ; Karjalainen-Lindsberg, Marja-Liisa ; Virkkunen, Pekka ; Leidenius, Marjut ; Smitten, Karl von ; Sipilä, Petri ; Fiedler, Stefan ; Suhonen, Heikki ; Suortti, Pekka ; Bravin, Alberto. / Toward high-contrast breast CT at low radiation dose : technical developments. Julkaisussa: Radiology. 2008 ; Vuosikerta 249, Nro 1. Sivut 321-327.
    @article{9cfdb3614eba49299f8e97818246808a,
    title = "Toward high-contrast breast CT at low radiation dose: technical developments",
    abstract = "This study was approved by the local research ethics committee, and patient informed consent was obtained. The purpose of this study was to demonstrate that high-spatial-resolution low-dose analyzer-based x-ray computed tomography (CT) can substantially improve the radiographic contrast of breast tissue in vitro when compared with that attained by using diagnostic mammography and CT. An excised human breast tumor was examined by using analyzer-based x-ray imaging with synchrotron radiation. The correspondence between analyzer-based x-ray images and diagnostic mammograms, CT images, and histopathologic findings was determined. Calcifications and fine details of soft tissue, which are at the contrast detection limit on diagnostic mammograms, are clearly visible on planar analyzer-based x-ray images. Analyzer-based x-ray CT yields high contrast from smoothly varying internal structures, such as tumorous mass lesions, corresponding to information on actual structures seen at histopathologic analysis. The mean glandular dose of 1.9 mGy in analyzer-based x-ray CT is approximately equivalent to the dose administered during single-view screening mammography. The improved visibility of mammo graphically indistinguishable lesions in vitro suggests that analyzer-based x-ray CT may be a valuable method in radiographic evaluation of the breast, thereby justifying further investigations. (c) RSNA, 2008.",
    author = "Jani Keyril{\"a}inen and Manuel Fernandez and Marja-Liisa Karjalainen-Lindsberg and Pekka Virkkunen and Marjut Leidenius and Smitten, {Karl von} and Petri Sipil{\"a} and Stefan Fiedler and Heikki Suhonen and Pekka Suortti and Alberto Bravin",
    year = "2008",
    doi = "10.1148/radiol.2491072129",
    language = "English",
    volume = "249",
    pages = "321--327",
    journal = "Radiology",
    issn = "0033-8419",
    publisher = "RADIOLOGICAL SOC NORTH AMERICA",
    number = "1",

    }

    Keyriläinen, J, Fernandez, M, Karjalainen-Lindsberg, M-L, Virkkunen, P, Leidenius, M, Smitten, KV, Sipilä, P, Fiedler, S, Suhonen, H, Suortti, P & Bravin, A 2008, 'Toward high-contrast breast CT at low radiation dose: technical developments', Radiology, Vuosikerta 249, Nro 1, Sivut 321-327. https://doi.org/10.1148/radiol.2491072129

    Toward high-contrast breast CT at low radiation dose : technical developments. / Keyriläinen, Jani; Fernandez, Manuel; Karjalainen-Lindsberg, Marja-Liisa; Virkkunen, Pekka; Leidenius, Marjut; Smitten, Karl von; Sipilä, Petri; Fiedler, Stefan; Suhonen, Heikki; Suortti, Pekka; Bravin, Alberto.

    julkaisussa: Radiology, Vuosikerta 249, Nro 1, 2008, s. 321-327.

    Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

    TY - JOUR

    T1 - Toward high-contrast breast CT at low radiation dose

    T2 - technical developments

    AU - Keyriläinen, Jani

    AU - Fernandez, Manuel

    AU - Karjalainen-Lindsberg, Marja-Liisa

    AU - Virkkunen, Pekka

    AU - Leidenius, Marjut

    AU - Smitten, Karl von

    AU - Sipilä, Petri

    AU - Fiedler, Stefan

    AU - Suhonen, Heikki

    AU - Suortti, Pekka

    AU - Bravin, Alberto

    PY - 2008

    Y1 - 2008

    N2 - This study was approved by the local research ethics committee, and patient informed consent was obtained. The purpose of this study was to demonstrate that high-spatial-resolution low-dose analyzer-based x-ray computed tomography (CT) can substantially improve the radiographic contrast of breast tissue in vitro when compared with that attained by using diagnostic mammography and CT. An excised human breast tumor was examined by using analyzer-based x-ray imaging with synchrotron radiation. The correspondence between analyzer-based x-ray images and diagnostic mammograms, CT images, and histopathologic findings was determined. Calcifications and fine details of soft tissue, which are at the contrast detection limit on diagnostic mammograms, are clearly visible on planar analyzer-based x-ray images. Analyzer-based x-ray CT yields high contrast from smoothly varying internal structures, such as tumorous mass lesions, corresponding to information on actual structures seen at histopathologic analysis. The mean glandular dose of 1.9 mGy in analyzer-based x-ray CT is approximately equivalent to the dose administered during single-view screening mammography. The improved visibility of mammo graphically indistinguishable lesions in vitro suggests that analyzer-based x-ray CT may be a valuable method in radiographic evaluation of the breast, thereby justifying further investigations. (c) RSNA, 2008.

    AB - This study was approved by the local research ethics committee, and patient informed consent was obtained. The purpose of this study was to demonstrate that high-spatial-resolution low-dose analyzer-based x-ray computed tomography (CT) can substantially improve the radiographic contrast of breast tissue in vitro when compared with that attained by using diagnostic mammography and CT. An excised human breast tumor was examined by using analyzer-based x-ray imaging with synchrotron radiation. The correspondence between analyzer-based x-ray images and diagnostic mammograms, CT images, and histopathologic findings was determined. Calcifications and fine details of soft tissue, which are at the contrast detection limit on diagnostic mammograms, are clearly visible on planar analyzer-based x-ray images. Analyzer-based x-ray CT yields high contrast from smoothly varying internal structures, such as tumorous mass lesions, corresponding to information on actual structures seen at histopathologic analysis. The mean glandular dose of 1.9 mGy in analyzer-based x-ray CT is approximately equivalent to the dose administered during single-view screening mammography. The improved visibility of mammo graphically indistinguishable lesions in vitro suggests that analyzer-based x-ray CT may be a valuable method in radiographic evaluation of the breast, thereby justifying further investigations. (c) RSNA, 2008.

    U2 - 10.1148/radiol.2491072129

    DO - 10.1148/radiol.2491072129

    M3 - Article

    VL - 249

    SP - 321

    EP - 327

    JO - Radiology

    JF - Radiology

    SN - 0033-8419

    IS - 1

    ER -