Transcription Factors Stat5a/b and Stat3 in Prostate Cancer Growth and Metastases

Tuomas Mirtti, Pooja Talati, Marja T Nevalainen

Tutkimustuotos: Artikkeli kirjassa/raportissa/konferenssijulkaisussaKirjan luku tai artikkeliTieteellinenvertaisarvioitu

Kuvaus

The majority of prostate cancer fatalities are caused by development of castration-resistant growth and metastatic spread of the primary tumor. There are currently no effective treatments for advanced prostate cancer and therefore it is imperative to develop more effective therapies for prostate cancer. Transcription factors Stat5a/b and Stat3 both represent potential therapeutic target proteins for advanced prostate cancer. Stat5 is the major signal transducer downstream of Prolactin (Prl) receptors in human prostate cancer cells, while Stat3 is known as the key mediator of the IL-6 effects. Stat5a/b and Stat3 both are constitutively active in clinical prostate cancers of high histological grades and in distant prostate cancer metastases. In addition, Stat5a/b and Stat3 both functionally interact with the androgen receptor in human prostate cancer cells. While both Stat5a/b and Stat3 bind to the same DNA consensus sequence, Stat5a/b regulates largely different genes from those that are regulated by Stat3 in human prostate cancer cells. Importantly, Stat5a/b has a preferential role over Stat3 in the promotion of prostate cancer cell viability and tumor growth. At the same time, both Stat5 and Stat3 stimulate metastatic behavior of human prostate cancer cells in vitro and in vivo . The Janus kinase family proteins (Jaks) are primary activators of Stat proteins. Inhibitors of Jak2 would target both transcription factors and theoretically provide control of prostate tumor growth as well as metastatic potential.
Alkuperäiskielienglanti
OtsikkoSignaling Pathways and Molecular Mediators in Metastasis : Transcription Factors Stat5a/b and Stat3 in Prostate Cancer Growth and Metastases
ToimittajatAlessandro Fatatis
Sivumäärä16
JulkaisupaikkaNetherlands
KustantajaSpringer
Julkaisupäivä2012
Sivut245-260
ISBN (painettu)978-94-007-2557-7
ISBN (elektroninen)978-94-007-2558-4
DOI - pysyväislinkit
TilaJulkaistu - 2012
OKM-julkaisutyyppiA3 Kirjan tai muun kokoomateoksen osa

Tieteenalat

  • 1182 Biokemia, solu- ja molekyylibiologia

Lainaa tätä

Mirtti, T., Talati, P., & Nevalainen, M. T. (2012). Transcription Factors Stat5a/b and Stat3 in Prostate Cancer Growth and Metastases. teoksessa A. Fatatis (Toimittaja), Signaling Pathways and Molecular Mediators in Metastasis : Transcription Factors Stat5a/b and Stat3 in Prostate Cancer Growth and Metastases (Sivut 245-260). Netherlands: Springer. https://doi.org/10.1007/978-94-007-2558-4_10
Mirtti, Tuomas ; Talati, Pooja ; Nevalainen, Marja T. / Transcription Factors Stat5a/b and Stat3 in Prostate Cancer Growth and Metastases. Signaling Pathways and Molecular Mediators in Metastasis : Transcription Factors Stat5a/b and Stat3 in Prostate Cancer Growth and Metastases. Toimittaja / Alessandro Fatatis. Netherlands : Springer, 2012. Sivut 245-260
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title = "Transcription Factors Stat5a/b and Stat3 in Prostate Cancer Growth and Metastases",
abstract = "The majority of prostate cancer fatalities are caused by development of castration-resistant growth and metastatic spread of the primary tumor. There are currently no effective treatments for advanced prostate cancer and therefore it is imperative to develop more effective therapies for prostate cancer. Transcription factors Stat5a/b and Stat3 both represent potential therapeutic target proteins for advanced prostate cancer. Stat5 is the major signal transducer downstream of Prolactin (Prl) receptors in human prostate cancer cells, while Stat3 is known as the key mediator of the IL-6 effects. Stat5a/b and Stat3 both are constitutively active in clinical prostate cancers of high histological grades and in distant prostate cancer metastases. In addition, Stat5a/b and Stat3 both functionally interact with the androgen receptor in human prostate cancer cells. While both Stat5a/b and Stat3 bind to the same DNA consensus sequence, Stat5a/b regulates largely different genes from those that are regulated by Stat3 in human prostate cancer cells. Importantly, Stat5a/b has a preferential role over Stat3 in the promotion of prostate cancer cell viability and tumor growth. At the same time, both Stat5 and Stat3 stimulate metastatic behavior of human prostate cancer cells in vitro and in vivo . The Janus kinase family proteins (Jaks) are primary activators of Stat proteins. Inhibitors of Jak2 would target both transcription factors and theoretically provide control of prostate tumor growth as well as metastatic potential.",
keywords = "1182 Biochemistry, cell and molecular biology, Prostate cancer, STAT5, STAT3, metastasis",
author = "Tuomas Mirtti and Pooja Talati and Nevalainen, {Marja T}",
year = "2012",
doi = "10.1007/978-94-007-2558-4_10",
language = "English",
isbn = "978-94-007-2557-7",
pages = "245--260",
editor = "Alessandro Fatatis",
booktitle = "Signaling Pathways and Molecular Mediators in Metastasis",
publisher = "Springer",
address = "United States",

}

Mirtti, T, Talati, P & Nevalainen, MT 2012, Transcription Factors Stat5a/b and Stat3 in Prostate Cancer Growth and Metastases. julkaisussa A Fatatis (Toimittaja), Signaling Pathways and Molecular Mediators in Metastasis : Transcription Factors Stat5a/b and Stat3 in Prostate Cancer Growth and Metastases. Springer, Netherlands, Sivut 245-260. https://doi.org/10.1007/978-94-007-2558-4_10

Transcription Factors Stat5a/b and Stat3 in Prostate Cancer Growth and Metastases. / Mirtti, Tuomas; Talati, Pooja; Nevalainen, Marja T.

Signaling Pathways and Molecular Mediators in Metastasis : Transcription Factors Stat5a/b and Stat3 in Prostate Cancer Growth and Metastases. toim. / Alessandro Fatatis. Netherlands : Springer, 2012. s. 245-260.

Tutkimustuotos: Artikkeli kirjassa/raportissa/konferenssijulkaisussaKirjan luku tai artikkeliTieteellinenvertaisarvioitu

TY - CHAP

T1 - Transcription Factors Stat5a/b and Stat3 in Prostate Cancer Growth and Metastases

AU - Mirtti, Tuomas

AU - Talati, Pooja

AU - Nevalainen, Marja T

PY - 2012

Y1 - 2012

N2 - The majority of prostate cancer fatalities are caused by development of castration-resistant growth and metastatic spread of the primary tumor. There are currently no effective treatments for advanced prostate cancer and therefore it is imperative to develop more effective therapies for prostate cancer. Transcription factors Stat5a/b and Stat3 both represent potential therapeutic target proteins for advanced prostate cancer. Stat5 is the major signal transducer downstream of Prolactin (Prl) receptors in human prostate cancer cells, while Stat3 is known as the key mediator of the IL-6 effects. Stat5a/b and Stat3 both are constitutively active in clinical prostate cancers of high histological grades and in distant prostate cancer metastases. In addition, Stat5a/b and Stat3 both functionally interact with the androgen receptor in human prostate cancer cells. While both Stat5a/b and Stat3 bind to the same DNA consensus sequence, Stat5a/b regulates largely different genes from those that are regulated by Stat3 in human prostate cancer cells. Importantly, Stat5a/b has a preferential role over Stat3 in the promotion of prostate cancer cell viability and tumor growth. At the same time, both Stat5 and Stat3 stimulate metastatic behavior of human prostate cancer cells in vitro and in vivo . The Janus kinase family proteins (Jaks) are primary activators of Stat proteins. Inhibitors of Jak2 would target both transcription factors and theoretically provide control of prostate tumor growth as well as metastatic potential.

AB - The majority of prostate cancer fatalities are caused by development of castration-resistant growth and metastatic spread of the primary tumor. There are currently no effective treatments for advanced prostate cancer and therefore it is imperative to develop more effective therapies for prostate cancer. Transcription factors Stat5a/b and Stat3 both represent potential therapeutic target proteins for advanced prostate cancer. Stat5 is the major signal transducer downstream of Prolactin (Prl) receptors in human prostate cancer cells, while Stat3 is known as the key mediator of the IL-6 effects. Stat5a/b and Stat3 both are constitutively active in clinical prostate cancers of high histological grades and in distant prostate cancer metastases. In addition, Stat5a/b and Stat3 both functionally interact with the androgen receptor in human prostate cancer cells. While both Stat5a/b and Stat3 bind to the same DNA consensus sequence, Stat5a/b regulates largely different genes from those that are regulated by Stat3 in human prostate cancer cells. Importantly, Stat5a/b has a preferential role over Stat3 in the promotion of prostate cancer cell viability and tumor growth. At the same time, both Stat5 and Stat3 stimulate metastatic behavior of human prostate cancer cells in vitro and in vivo . The Janus kinase family proteins (Jaks) are primary activators of Stat proteins. Inhibitors of Jak2 would target both transcription factors and theoretically provide control of prostate tumor growth as well as metastatic potential.

KW - 1182 Biochemistry, cell and molecular biology

KW - Prostate cancer

KW - STAT5

KW - STAT3

KW - metastasis

U2 - 10.1007/978-94-007-2558-4_10

DO - 10.1007/978-94-007-2558-4_10

M3 - Chapter

SN - 978-94-007-2557-7

SP - 245

EP - 260

BT - Signaling Pathways and Molecular Mediators in Metastasis

A2 - Fatatis, Alessandro

PB - Springer

CY - Netherlands

ER -

Mirtti T, Talati P, Nevalainen MT. Transcription Factors Stat5a/b and Stat3 in Prostate Cancer Growth and Metastases. julkaisussa Fatatis A, toimittaja, Signaling Pathways and Molecular Mediators in Metastasis : Transcription Factors Stat5a/b and Stat3 in Prostate Cancer Growth and Metastases. Netherlands: Springer. 2012. s. 245-260 https://doi.org/10.1007/978-94-007-2558-4_10