Transphyseal bioabsorbable screws cause temporary growth retardation in rabbit femur

Eero Waris, Nureddin Ashammakhi, Christopher Kelly, Lee Andrus, Timo Waris, Ian Jackson

    Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

    Kuvaus

    A self-reinforced bioabsorbable poly-L-lactide/polyglycolide (SR-PLGA) 80/20 screw 2.0 mm in diameter was implanted transphyseally across the distal growth plate of the right femur in 24 immature rabbits. Radiologic evaluation revealed a mean shortening of 3.1 mm at 3 weeks, 11.1 mm at 6 weeks, 9.3 mm at 24 weeks, 9.0 mm at 48 weeks, and 12.6 mm at 72 weeks compared with the intact contralateral femur. In 13 control rabbits, drilling without screw placement did not cause any statistically significant femoral shortening. Therefore, the transphyseal SR-PLGA 80/20 screw caused growth retardation for 6 weeks postoperatively, after which the normal growth tendency was recovered until the growth plate was closed. The duration of temporary growth retardation correlated with that of strength retention of the SR-PLGA 80/20 copolymer. These findings suggest that SR-PLGA 80/20 screws can be applied in transphyseal bone fixation. The use of bioabsorbable screws for temporary epiphysiodesis seems attractive but requires further study.
    Alkuperäiskielienglanti
    LehtiJournal of Pediatric Orthopaedics
    Vuosikerta25
    Numero3
    Sivut342-345
    Sivumäärä4
    ISSN0271-6798
    TilaJulkaistu - 2005
    OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

    Lainaa tätä

    Waris, E., Ashammakhi, N., Kelly, C., Andrus, L., Waris, T., & Jackson, I. (2005). Transphyseal bioabsorbable screws cause temporary growth retardation in rabbit femur. Journal of Pediatric Orthopaedics, 25(3), 342-345.
    Waris, Eero ; Ashammakhi, Nureddin ; Kelly, Christopher ; Andrus, Lee ; Waris, Timo ; Jackson, Ian. / Transphyseal bioabsorbable screws cause temporary growth retardation in rabbit femur. Julkaisussa: Journal of Pediatric Orthopaedics. 2005 ; Vuosikerta 25, Nro 3. Sivut 342-345.
    @article{077c96e559bb4f59b26f2be1d18cae2c,
    title = "Transphyseal bioabsorbable screws cause temporary growth retardation in rabbit femur",
    abstract = "A self-reinforced bioabsorbable poly-L-lactide/polyglycolide (SR-PLGA) 80/20 screw 2.0 mm in diameter was implanted transphyseally across the distal growth plate of the right femur in 24 immature rabbits. Radiologic evaluation revealed a mean shortening of 3.1 mm at 3 weeks, 11.1 mm at 6 weeks, 9.3 mm at 24 weeks, 9.0 mm at 48 weeks, and 12.6 mm at 72 weeks compared with the intact contralateral femur. In 13 control rabbits, drilling without screw placement did not cause any statistically significant femoral shortening. Therefore, the transphyseal SR-PLGA 80/20 screw caused growth retardation for 6 weeks postoperatively, after which the normal growth tendency was recovered until the growth plate was closed. The duration of temporary growth retardation correlated with that of strength retention of the SR-PLGA 80/20 copolymer. These findings suggest that SR-PLGA 80/20 screws can be applied in transphyseal bone fixation. The use of bioabsorbable screws for temporary epiphysiodesis seems attractive but requires further study.",
    author = "Eero Waris and Nureddin Ashammakhi and Christopher Kelly and Lee Andrus and Timo Waris and Ian Jackson",
    year = "2005",
    language = "English",
    volume = "25",
    pages = "342--345",
    journal = "Journal of Pediatric Orthopaedics",
    issn = "0271-6798",
    publisher = "LIPPINCOTT WILLIAMS & WILKINS",
    number = "3",

    }

    Waris, E, Ashammakhi, N, Kelly, C, Andrus, L, Waris, T & Jackson, I 2005, 'Transphyseal bioabsorbable screws cause temporary growth retardation in rabbit femur', Journal of Pediatric Orthopaedics, Vuosikerta 25, Nro 3, Sivut 342-345.

    Transphyseal bioabsorbable screws cause temporary growth retardation in rabbit femur. / Waris, Eero; Ashammakhi, Nureddin; Kelly, Christopher; Andrus, Lee; Waris, Timo; Jackson, Ian.

    julkaisussa: Journal of Pediatric Orthopaedics, Vuosikerta 25, Nro 3, 2005, s. 342-345.

    Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

    TY - JOUR

    T1 - Transphyseal bioabsorbable screws cause temporary growth retardation in rabbit femur

    AU - Waris, Eero

    AU - Ashammakhi, Nureddin

    AU - Kelly, Christopher

    AU - Andrus, Lee

    AU - Waris, Timo

    AU - Jackson, Ian

    PY - 2005

    Y1 - 2005

    N2 - A self-reinforced bioabsorbable poly-L-lactide/polyglycolide (SR-PLGA) 80/20 screw 2.0 mm in diameter was implanted transphyseally across the distal growth plate of the right femur in 24 immature rabbits. Radiologic evaluation revealed a mean shortening of 3.1 mm at 3 weeks, 11.1 mm at 6 weeks, 9.3 mm at 24 weeks, 9.0 mm at 48 weeks, and 12.6 mm at 72 weeks compared with the intact contralateral femur. In 13 control rabbits, drilling without screw placement did not cause any statistically significant femoral shortening. Therefore, the transphyseal SR-PLGA 80/20 screw caused growth retardation for 6 weeks postoperatively, after which the normal growth tendency was recovered until the growth plate was closed. The duration of temporary growth retardation correlated with that of strength retention of the SR-PLGA 80/20 copolymer. These findings suggest that SR-PLGA 80/20 screws can be applied in transphyseal bone fixation. The use of bioabsorbable screws for temporary epiphysiodesis seems attractive but requires further study.

    AB - A self-reinforced bioabsorbable poly-L-lactide/polyglycolide (SR-PLGA) 80/20 screw 2.0 mm in diameter was implanted transphyseally across the distal growth plate of the right femur in 24 immature rabbits. Radiologic evaluation revealed a mean shortening of 3.1 mm at 3 weeks, 11.1 mm at 6 weeks, 9.3 mm at 24 weeks, 9.0 mm at 48 weeks, and 12.6 mm at 72 weeks compared with the intact contralateral femur. In 13 control rabbits, drilling without screw placement did not cause any statistically significant femoral shortening. Therefore, the transphyseal SR-PLGA 80/20 screw caused growth retardation for 6 weeks postoperatively, after which the normal growth tendency was recovered until the growth plate was closed. The duration of temporary growth retardation correlated with that of strength retention of the SR-PLGA 80/20 copolymer. These findings suggest that SR-PLGA 80/20 screws can be applied in transphyseal bone fixation. The use of bioabsorbable screws for temporary epiphysiodesis seems attractive but requires further study.

    M3 - Article

    VL - 25

    SP - 342

    EP - 345

    JO - Journal of Pediatric Orthopaedics

    JF - Journal of Pediatric Orthopaedics

    SN - 0271-6798

    IS - 3

    ER -