Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy

Tuying Yong, Xiaoqiong Zhang, Nana Bie, Hongbo Zhang, Xuting Zhang, Fuying Li, Abdul Hakeem, Jun Hu, Lu Gan, Hélder A. Santos, Xiangliang Yang

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Kuvaus

Developing biomimetic nanoparticles without loss of the integrity of proteins remains a major challenge in cancer chemotherapy. Here, we develop a biocompatible tumor-cell-exocytosed exosome-biomimetic porous silicon nanoparticles (PSiNPs) as drug carrier for targeted cancer chemotherapy. Exosome-sheathed doxorubicin-loaded PSiNPs (DOX@E-PSiNPs), generated by exocytosis of the endocytosed DOX-loaded PSiNPs from tumor cells, exhibit enhanced tumor accumulation, extravasation from blood vessels and penetration into deep tumor parenchyma following intravenous administration. In addition, DOX@E-PSiNPs, regardless of their origin, possess significant cellular uptake and cytotoxicity in both bulk cancer cells and cancer stem cells (CSCs). These properties endow DOX@E-PSiNPs with great in vivo enrichment in total tumor cells and side population cells with features of CSCs, resulting in anticancer activity and CSCs reduction in subcutaneous, orthotopic and metastatic tumor models. These results provide a proof-of-concept for the use of exosome-biomimetic nanoparticles exocytosed from tumor cells as a promising drug carrier for efficient cancer chemotherapy.
Alkuperäiskielienglanti
LehtiNature Communications
Vuosikerta10
Numero1
Sivut3838
Sivumäärä16
ISSN2041-1723
DOI - pysyväislinkit
TilaJulkaistu - 23 elokuuta 2019
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Lainaa tätä

Yong, T., Zhang, X., Bie, N., Zhang, H., Zhang, X., Li, F., ... Yang, X. (2019). Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy. Nature Communications, 10(1), 3838. https://doi.org/10.1038/s41467-019-11718-4
Yong, Tuying ; Zhang, Xiaoqiong ; Bie, Nana ; Zhang, Hongbo ; Zhang, Xuting ; Li, Fuying ; Hakeem, Abdul ; Hu, Jun ; Gan, Lu ; Santos, Hélder A. ; Yang, Xiangliang. / Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy. Julkaisussa: Nature Communications. 2019 ; Vuosikerta 10, Nro 1. Sivut 3838.
@article{d4172203322843f996e36054261590eb,
title = "Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy",
abstract = "Developing biomimetic nanoparticles without loss of the integrity of proteins remains a major challenge in cancer chemotherapy. Here, we develop a biocompatible tumor-cell-exocytosed exosome-biomimetic porous silicon nanoparticles (PSiNPs) as drug carrier for targeted cancer chemotherapy. Exosome-sheathed doxorubicin-loaded PSiNPs (DOX@E-PSiNPs), generated by exocytosis of the endocytosed DOX-loaded PSiNPs from tumor cells, exhibit enhanced tumor accumulation, extravasation from blood vessels and penetration into deep tumor parenchyma following intravenous administration. In addition, DOX@E-PSiNPs, regardless of their origin, possess significant cellular uptake and cytotoxicity in both bulk cancer cells and cancer stem cells (CSCs). These properties endow DOX@E-PSiNPs with great in vivo enrichment in total tumor cells and side population cells with features of CSCs, resulting in anticancer activity and CSCs reduction in subcutaneous, orthotopic and metastatic tumor models. These results provide a proof-of-concept for the use of exosome-biomimetic nanoparticles exocytosed from tumor cells as a promising drug carrier for efficient cancer chemotherapy.",
author = "Tuying Yong and Xiaoqiong Zhang and Nana Bie and Hongbo Zhang and Xuting Zhang and Fuying Li and Abdul Hakeem and Jun Hu and Lu Gan and Santos, {H{\'e}lder A.} and Xiangliang Yang",
year = "2019",
month = "8",
day = "23",
doi = "10.1038/s41467-019-11718-4",
language = "English",
volume = "10",
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journal = "Nature Communications",
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Yong, T, Zhang, X, Bie, N, Zhang, H, Zhang, X, Li, F, Hakeem, A, Hu, J, Gan, L, Santos, HA & Yang, X 2019, 'Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy', Nature Communications, Vuosikerta 10, Nro 1, Sivut 3838. https://doi.org/10.1038/s41467-019-11718-4

Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy. / Yong, Tuying; Zhang, Xiaoqiong; Bie, Nana; Zhang, Hongbo; Zhang, Xuting; Li, Fuying; Hakeem, Abdul; Hu, Jun; Gan, Lu; Santos, Hélder A.; Yang, Xiangliang.

julkaisussa: Nature Communications, Vuosikerta 10, Nro 1, 23.08.2019, s. 3838.

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

TY - JOUR

T1 - Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy

AU - Yong, Tuying

AU - Zhang, Xiaoqiong

AU - Bie, Nana

AU - Zhang, Hongbo

AU - Zhang, Xuting

AU - Li, Fuying

AU - Hakeem, Abdul

AU - Hu, Jun

AU - Gan, Lu

AU - Santos, Hélder A.

AU - Yang, Xiangliang

PY - 2019/8/23

Y1 - 2019/8/23

N2 - Developing biomimetic nanoparticles without loss of the integrity of proteins remains a major challenge in cancer chemotherapy. Here, we develop a biocompatible tumor-cell-exocytosed exosome-biomimetic porous silicon nanoparticles (PSiNPs) as drug carrier for targeted cancer chemotherapy. Exosome-sheathed doxorubicin-loaded PSiNPs (DOX@E-PSiNPs), generated by exocytosis of the endocytosed DOX-loaded PSiNPs from tumor cells, exhibit enhanced tumor accumulation, extravasation from blood vessels and penetration into deep tumor parenchyma following intravenous administration. In addition, DOX@E-PSiNPs, regardless of their origin, possess significant cellular uptake and cytotoxicity in both bulk cancer cells and cancer stem cells (CSCs). These properties endow DOX@E-PSiNPs with great in vivo enrichment in total tumor cells and side population cells with features of CSCs, resulting in anticancer activity and CSCs reduction in subcutaneous, orthotopic and metastatic tumor models. These results provide a proof-of-concept for the use of exosome-biomimetic nanoparticles exocytosed from tumor cells as a promising drug carrier for efficient cancer chemotherapy.

AB - Developing biomimetic nanoparticles without loss of the integrity of proteins remains a major challenge in cancer chemotherapy. Here, we develop a biocompatible tumor-cell-exocytosed exosome-biomimetic porous silicon nanoparticles (PSiNPs) as drug carrier for targeted cancer chemotherapy. Exosome-sheathed doxorubicin-loaded PSiNPs (DOX@E-PSiNPs), generated by exocytosis of the endocytosed DOX-loaded PSiNPs from tumor cells, exhibit enhanced tumor accumulation, extravasation from blood vessels and penetration into deep tumor parenchyma following intravenous administration. In addition, DOX@E-PSiNPs, regardless of their origin, possess significant cellular uptake and cytotoxicity in both bulk cancer cells and cancer stem cells (CSCs). These properties endow DOX@E-PSiNPs with great in vivo enrichment in total tumor cells and side population cells with features of CSCs, resulting in anticancer activity and CSCs reduction in subcutaneous, orthotopic and metastatic tumor models. These results provide a proof-of-concept for the use of exosome-biomimetic nanoparticles exocytosed from tumor cells as a promising drug carrier for efficient cancer chemotherapy.

UR - https://www.nature.com/ncomms/

U2 - 10.1038/s41467-019-11718-4

DO - 10.1038/s41467-019-11718-4

M3 - Article

VL - 10

SP - 3838

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

ER -