Use of exogenous hormones and the risk of breast cancer: results from self-reported survey data with validity assessment

Sanna Heikkinen, Markku Juhani Koskenvuo, Nea Malila, Tytti Sarkeala, Eero Pukkala, Janne Pitkäniemi

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Kuvaus

PURPOSE:

Main aim was to estimate the association between use of exogenous hormones and breast cancer (BC) risk in a large population-based survey, and to assess the representativeness and overall validity of the data.

METHODS:

The survey 'Women's Health and Use of Hormones' was conducted in Finland in 2009, including 7,000 BC cases and 20,000 matched population controls. Conditional logistic regression was used to estimate odds ratios and their 95 % confidence interval. For validation, exposure prevalences were compared with population data from Statistics Finland and two large population-based surveys.

RESULTS:

We found positive associations with BC risk and exclusive use of hormone-releasing intrauterine device (HR IUD) in postmenopausal women (1.48, 95 % CI 1.10-1.99), when compared to never-users of any hormonal contraceptive and considering only prediagnostic use in cases. Regarding use of other hormonal contraceptives (HC), a positive association between long HC use (≥2 years) and BC was observed in both groups, OR being 1.37 (95 % CI 1.12-1.68) for premenopausal and 1.11 (95 % CI 1.03-1.20) for postmenopausal women, when compared to never-users of other HC.

CONCLUSIONS:

Observed association between HR IUD use and risk of BC in postmenopausal women is worrying and deserves further attention. Selection bias seemed not to explain this result. Considering the increasing popularity of HR IUD use in, e.g., USA, impact of possible adverse effects in public health could be significant.
Alkuperäiskielienglanti
LehtiCancer Causes & Control
Vuosikerta27
Numero2
Sivut249-258
Sivumäärä10
ISSN0957-5243
DOI - pysyväislinkit
TilaJulkaistu - helmikuuta 2016
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

  • 3142 Kansanterveystiede, ympäristö ja työterveys
  • 3122 Syöpätaudit

Lainaa tätä

Heikkinen, Sanna ; Koskenvuo, Markku Juhani ; Malila, Nea ; Sarkeala, Tytti ; Pukkala, Eero ; Pitkäniemi, Janne. / Use of exogenous hormones and the risk of breast cancer: results from self-reported survey data with validity assessment. Julkaisussa: Cancer Causes & Control. 2016 ; Vuosikerta 27, Nro 2. Sivut 249-258.
@article{03c6d8b179e34c90895ffece3d8f56a4,
title = "Use of exogenous hormones and the risk of breast cancer: results from self-reported survey data with validity assessment",
abstract = "PURPOSE: Main aim was to estimate the association between use of exogenous hormones and breast cancer (BC) risk in a large population-based survey, and to assess the representativeness and overall validity of the data.METHODS: The survey 'Women's Health and Use of Hormones' was conducted in Finland in 2009, including 7,000 BC cases and 20,000 matched population controls. Conditional logistic regression was used to estimate odds ratios and their 95 {\%} confidence interval. For validation, exposure prevalences were compared with population data from Statistics Finland and two large population-based surveys.RESULTS: We found positive associations with BC risk and exclusive use of hormone-releasing intrauterine device (HR IUD) in postmenopausal women (1.48, 95 {\%} CI 1.10-1.99), when compared to never-users of any hormonal contraceptive and considering only prediagnostic use in cases. Regarding use of other hormonal contraceptives (HC), a positive association between long HC use (≥2 years) and BC was observed in both groups, OR being 1.37 (95 {\%} CI 1.12-1.68) for premenopausal and 1.11 (95 {\%} CI 1.03-1.20) for postmenopausal women, when compared to never-users of other HC.CONCLUSIONS: Observed association between HR IUD use and risk of BC in postmenopausal women is worrying and deserves further attention. Selection bias seemed not to explain this result. Considering the increasing popularity of HR IUD use in, e.g., USA, impact of possible adverse effects in public health could be significant.",
keywords = "3142 Public health care science, environmental and occupational health, breast cancer, case-control study, epidemiology, hormonal contraceptive, intrauterine device, 3122 Cancers",
author = "Sanna Heikkinen and Koskenvuo, {Markku Juhani} and Nea Malila and Tytti Sarkeala and Eero Pukkala and Janne Pitk{\"a}niemi",
year = "2016",
month = "2",
doi = "10.1007/s10552-015-0702-5",
language = "English",
volume = "27",
pages = "249--258",
journal = "Cancer Causes & Control",
issn = "0957-5243",
publisher = "Springer",
number = "2",

}

Use of exogenous hormones and the risk of breast cancer: results from self-reported survey data with validity assessment. / Heikkinen, Sanna; Koskenvuo, Markku Juhani; Malila, Nea; Sarkeala, Tytti; Pukkala, Eero; Pitkäniemi, Janne.

julkaisussa: Cancer Causes & Control, Vuosikerta 27, Nro 2, 02.2016, s. 249-258.

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

TY - JOUR

T1 - Use of exogenous hormones and the risk of breast cancer: results from self-reported survey data with validity assessment

AU - Heikkinen, Sanna

AU - Koskenvuo, Markku Juhani

AU - Malila, Nea

AU - Sarkeala, Tytti

AU - Pukkala, Eero

AU - Pitkäniemi, Janne

PY - 2016/2

Y1 - 2016/2

N2 - PURPOSE: Main aim was to estimate the association between use of exogenous hormones and breast cancer (BC) risk in a large population-based survey, and to assess the representativeness and overall validity of the data.METHODS: The survey 'Women's Health and Use of Hormones' was conducted in Finland in 2009, including 7,000 BC cases and 20,000 matched population controls. Conditional logistic regression was used to estimate odds ratios and their 95 % confidence interval. For validation, exposure prevalences were compared with population data from Statistics Finland and two large population-based surveys.RESULTS: We found positive associations with BC risk and exclusive use of hormone-releasing intrauterine device (HR IUD) in postmenopausal women (1.48, 95 % CI 1.10-1.99), when compared to never-users of any hormonal contraceptive and considering only prediagnostic use in cases. Regarding use of other hormonal contraceptives (HC), a positive association between long HC use (≥2 years) and BC was observed in both groups, OR being 1.37 (95 % CI 1.12-1.68) for premenopausal and 1.11 (95 % CI 1.03-1.20) for postmenopausal women, when compared to never-users of other HC.CONCLUSIONS: Observed association between HR IUD use and risk of BC in postmenopausal women is worrying and deserves further attention. Selection bias seemed not to explain this result. Considering the increasing popularity of HR IUD use in, e.g., USA, impact of possible adverse effects in public health could be significant.

AB - PURPOSE: Main aim was to estimate the association between use of exogenous hormones and breast cancer (BC) risk in a large population-based survey, and to assess the representativeness and overall validity of the data.METHODS: The survey 'Women's Health and Use of Hormones' was conducted in Finland in 2009, including 7,000 BC cases and 20,000 matched population controls. Conditional logistic regression was used to estimate odds ratios and their 95 % confidence interval. For validation, exposure prevalences were compared with population data from Statistics Finland and two large population-based surveys.RESULTS: We found positive associations with BC risk and exclusive use of hormone-releasing intrauterine device (HR IUD) in postmenopausal women (1.48, 95 % CI 1.10-1.99), when compared to never-users of any hormonal contraceptive and considering only prediagnostic use in cases. Regarding use of other hormonal contraceptives (HC), a positive association between long HC use (≥2 years) and BC was observed in both groups, OR being 1.37 (95 % CI 1.12-1.68) for premenopausal and 1.11 (95 % CI 1.03-1.20) for postmenopausal women, when compared to never-users of other HC.CONCLUSIONS: Observed association between HR IUD use and risk of BC in postmenopausal women is worrying and deserves further attention. Selection bias seemed not to explain this result. Considering the increasing popularity of HR IUD use in, e.g., USA, impact of possible adverse effects in public health could be significant.

KW - 3142 Public health care science, environmental and occupational health

KW - breast cancer

KW - case-control study

KW - epidemiology

KW - hormonal contraceptive

KW - intrauterine device

KW - 3122 Cancers

U2 - 10.1007/s10552-015-0702-5

DO - 10.1007/s10552-015-0702-5

M3 - Article

VL - 27

SP - 249

EP - 258

JO - Cancer Causes & Control

JF - Cancer Causes & Control

SN - 0957-5243

IS - 2

ER -