Visualisation of calcifications and thin collagen strands in human breast tumour specimens by the diffraction-enhanced imaging technique: a comparison with conventional mammography and histology

Jani Keyriläinen, Manuel Fernandez, Stefan Fiedler, Alberto Bravin, Marja-Liisa Karjalainen-Lindsberg, Pekka Virkkunen, Eva-Maria Elo, Mikko Tenhunen, Pekka Suortti, William Thomlinson

    Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

    Kuvaus

    Six excised human breast tissue specimens carrying benign and malignant tumours were examined with the diffraction-enhanced imaging technique. Diffraction-enhanced images were compared with diagnostic screen-film mammograms and the correlation with histological information of the specimens was established. The enhanced visibility of calcifications, some of which were smaller than 0.15 mm in diameter, is reported in detail. Fine details of the structures such as strands of collagen and contours between glandular and adipose tissue, which are barely visible at the contrast detection limit in the conventional absorption-based mammograms, are clearly visible in the diffraction-enhanced images. Microscopic study of the stained histopathological sections unequivocally confirms the correlation of the radiographic findings with the morphologic changes in specimens. An increased soft tissue contrast and a combination of information obtained with disparate diffraction-enhanced images provide better visibility of mammographically indistinguishable features. This kind of additional structural information of the breast tissue is required to improve assessment accuracy and earlier detection of the breast lesions. These advances in image quality make the method a very promising candidate for mammography. (C) 2004 Elsevier B.V. All rights reserved.
    Alkuperäiskielienglanti
    LehtiEuropean Journal of Radiology
    Vuosikerta53
    Numero2
    Sivut226-237
    Sivumäärä12
    ISSN0720-048X
    DOI - pysyväislinkit
    TilaJulkaistu - 2005
    OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

    Lainaa tätä

    Keyriläinen, Jani ; Fernandez, Manuel ; Fiedler, Stefan ; Bravin, Alberto ; Karjalainen-Lindsberg, Marja-Liisa ; Virkkunen, Pekka ; Elo, Eva-Maria ; Tenhunen, Mikko ; Suortti, Pekka ; Thomlinson, William. / Visualisation of calcifications and thin collagen strands in human breast tumour specimens by the diffraction-enhanced imaging technique : a comparison with conventional mammography and histology. Julkaisussa: European Journal of Radiology. 2005 ; Vuosikerta 53, Nro 2. Sivut 226-237.
    @article{7b0a527281d645029c45cf77429afcb4,
    title = "Visualisation of calcifications and thin collagen strands in human breast tumour specimens by the diffraction-enhanced imaging technique: a comparison with conventional mammography and histology",
    abstract = "Six excised human breast tissue specimens carrying benign and malignant tumours were examined with the diffraction-enhanced imaging technique. Diffraction-enhanced images were compared with diagnostic screen-film mammograms and the correlation with histological information of the specimens was established. The enhanced visibility of calcifications, some of which were smaller than 0.15 mm in diameter, is reported in detail. Fine details of the structures such as strands of collagen and contours between glandular and adipose tissue, which are barely visible at the contrast detection limit in the conventional absorption-based mammograms, are clearly visible in the diffraction-enhanced images. Microscopic study of the stained histopathological sections unequivocally confirms the correlation of the radiographic findings with the morphologic changes in specimens. An increased soft tissue contrast and a combination of information obtained with disparate diffraction-enhanced images provide better visibility of mammographically indistinguishable features. This kind of additional structural information of the breast tissue is required to improve assessment accuracy and earlier detection of the breast lesions. These advances in image quality make the method a very promising candidate for mammography. (C) 2004 Elsevier B.V. All rights reserved.",
    author = "Jani Keyril{\"a}inen and Manuel Fernandez and Stefan Fiedler and Alberto Bravin and Marja-Liisa Karjalainen-Lindsberg and Pekka Virkkunen and Eva-Maria Elo and Mikko Tenhunen and Pekka Suortti and William Thomlinson",
    year = "2005",
    doi = "10.1016/j.ejard.2004.03.015",
    language = "English",
    volume = "53",
    pages = "226--237",
    journal = "European Journal of Radiology",
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    publisher = "ELSEVIER IRELAND LTD",
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    Visualisation of calcifications and thin collagen strands in human breast tumour specimens by the diffraction-enhanced imaging technique : a comparison with conventional mammography and histology. / Keyriläinen, Jani; Fernandez, Manuel; Fiedler, Stefan; Bravin, Alberto; Karjalainen-Lindsberg, Marja-Liisa; Virkkunen, Pekka; Elo, Eva-Maria; Tenhunen, Mikko; Suortti, Pekka; Thomlinson, William.

    julkaisussa: European Journal of Radiology, Vuosikerta 53, Nro 2, 2005, s. 226-237.

    Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

    TY - JOUR

    T1 - Visualisation of calcifications and thin collagen strands in human breast tumour specimens by the diffraction-enhanced imaging technique

    T2 - a comparison with conventional mammography and histology

    AU - Keyriläinen, Jani

    AU - Fernandez, Manuel

    AU - Fiedler, Stefan

    AU - Bravin, Alberto

    AU - Karjalainen-Lindsberg, Marja-Liisa

    AU - Virkkunen, Pekka

    AU - Elo, Eva-Maria

    AU - Tenhunen, Mikko

    AU - Suortti, Pekka

    AU - Thomlinson, William

    PY - 2005

    Y1 - 2005

    N2 - Six excised human breast tissue specimens carrying benign and malignant tumours were examined with the diffraction-enhanced imaging technique. Diffraction-enhanced images were compared with diagnostic screen-film mammograms and the correlation with histological information of the specimens was established. The enhanced visibility of calcifications, some of which were smaller than 0.15 mm in diameter, is reported in detail. Fine details of the structures such as strands of collagen and contours between glandular and adipose tissue, which are barely visible at the contrast detection limit in the conventional absorption-based mammograms, are clearly visible in the diffraction-enhanced images. Microscopic study of the stained histopathological sections unequivocally confirms the correlation of the radiographic findings with the morphologic changes in specimens. An increased soft tissue contrast and a combination of information obtained with disparate diffraction-enhanced images provide better visibility of mammographically indistinguishable features. This kind of additional structural information of the breast tissue is required to improve assessment accuracy and earlier detection of the breast lesions. These advances in image quality make the method a very promising candidate for mammography. (C) 2004 Elsevier B.V. All rights reserved.

    AB - Six excised human breast tissue specimens carrying benign and malignant tumours were examined with the diffraction-enhanced imaging technique. Diffraction-enhanced images were compared with diagnostic screen-film mammograms and the correlation with histological information of the specimens was established. The enhanced visibility of calcifications, some of which were smaller than 0.15 mm in diameter, is reported in detail. Fine details of the structures such as strands of collagen and contours between glandular and adipose tissue, which are barely visible at the contrast detection limit in the conventional absorption-based mammograms, are clearly visible in the diffraction-enhanced images. Microscopic study of the stained histopathological sections unequivocally confirms the correlation of the radiographic findings with the morphologic changes in specimens. An increased soft tissue contrast and a combination of information obtained with disparate diffraction-enhanced images provide better visibility of mammographically indistinguishable features. This kind of additional structural information of the breast tissue is required to improve assessment accuracy and earlier detection of the breast lesions. These advances in image quality make the method a very promising candidate for mammography. (C) 2004 Elsevier B.V. All rights reserved.

    U2 - 10.1016/j.ejard.2004.03.015

    DO - 10.1016/j.ejard.2004.03.015

    M3 - Article

    VL - 53

    SP - 226

    EP - 237

    JO - European Journal of Radiology

    JF - European Journal of Radiology

    SN - 0720-048X

    IS - 2

    ER -