Waist and hip circumference are independently associated with the risk of liver disease in population-based studies

Oscar A Danielsson; Markku Nissinen; Antti Jula; Veikko Salomaa; Satu Männistö; Annamari Lundqvist; Markus Perola; Fredrik Åberg

doi:10.1111/liv.15053

Waist and hip circumference are independently associated with the risk of liver disease in population-based studies

Oscar A Danielsson, Markku Nissinen, Antti Jula, Veikko Salomaa, Satu Männistö, Annamari Lundqvist, Markus Perola, Fredrik Åberg

Tutkimustuotos: Artikkelijulkaisu › Artikkeli › Tieteellinen › vertaisarvioitu

Abstrakti

Background & Aims While several anthropometric measures predict liver disease, the waist-hip ratio (WHR) has shown superiority in previous studies. We analysed independent and joint associations of waist circumference (WC) and hip circumference (HC) with liver disease and liver-related risk factors. Methods Cross-sectional study (n = 6619) and longitudinal cohort (n = 40 923) comprised individuals from Health 2000 and FINRISK 1992-2012 studies. Prevalent and viral liver diseases were excluded. Longitudinal cohort was linked with national healthcare registers for severe incident liver disease. Linear regression and Cox proportional hazards models were used to analyse anthropometric, lifestyle, metabolic and bioimpedance-related parameters; liver enzymes; and 59 liver-related genetic risk variants. Results WC and HC showed independent and opposite associations with both liver enzymes and incident liver disease among men (HR for liver disease: WC, 1.07, 95% CI 1.03-1.11; HC, 0.96, 95% CI 0.92-0.99; P-range .04 to

Alkuperäiskieli	englanti
Lehti	Liver International
Vuosikerta	41
Numero	12
Sivut	2903-2913
Sivumäärä	11
ISSN	1478-3223
DOI - pysyväislinkit	https://doi.org/10.1111/liv.15053
Tila	Julkaistu - jouluk. 2021
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

3121 Yleislääketiede, sisätaudit ja muut kliiniset lääketieteet

Pääsy asiakirjaan

10.1111/liv.15053

Liver International - 2021 - Danielsson - Waist and hip circumference are independently associated with the risk of liverLopullinen julkaistu versio, 1,09 MBLisenssi: CC BY

Siteeraa tätä

@article{5e98b0822f954f419fcc34c93d3c077c,

title = "Waist and hip circumference are independently associated with the risk of liver disease in population-based studies",

abstract = "Background & Aims While several anthropometric measures predict liver disease, the waist-hip ratio (WHR) has shown superiority in previous studies. We analysed independent and joint associations of waist circumference (WC) and hip circumference (HC) with liver disease and liver-related risk factors. Methods Cross-sectional study (n = 6619) and longitudinal cohort (n = 40 923) comprised individuals from Health 2000 and FINRISK 1992-2012 studies. Prevalent and viral liver diseases were excluded. Longitudinal cohort was linked with national healthcare registers for severe incident liver disease. Linear regression and Cox proportional hazards models were used to analyse anthropometric, lifestyle, metabolic and bioimpedance-related parameters; liver enzymes; and 59 liver-related genetic risk variants. Results WC and HC showed independent and opposite associations with both liver enzymes and incident liver disease among men (HR for liver disease: WC, 1.07, 95% CI 1.03-1.11; HC, 0.96, 95% CI 0.92-0.99; P-range .04 to",

keywords = "BODY-COMPOSITION, CARDIOVASCULAR RISK, FATTY LIVER, INSULIN-RESISTANCE, NORMAL-WEIGHT, OBESITY, PREDICTS DEVELOPMENT, RATIO, SKELETAL-MUSCLE MASS, WHOLE-BODY, anthropometric measures, body mass index, fat, sarcopenia, waist-hip ratio, 3121 General medicine, internal medicine and other clinical medicine",

author = "Danielsson, {Oscar A} and Markku Nissinen and Antti Jula and Veikko Salomaa and Satu M{\"a}nnist{\"o} and Annamari Lundqvist and Markus Perola and Fredrik {\AA}berg",

year = "2021",

month = dec,

doi = "10.1111/liv.15053",

language = "English",

volume = "41",

pages = "2903--2913",

journal = "Liver International",

issn = "1478-3223",

publisher = "Wiley",

number = "12",

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TY - JOUR

T1 - Waist and hip circumference are independently associated with the risk of liver disease in population-based studies

AU - Danielsson, Oscar A

AU - Nissinen, Markku

AU - Jula, Antti

AU - Salomaa, Veikko

AU - Männistö, Satu

AU - Lundqvist, Annamari

AU - Perola, Markus

AU - Åberg, Fredrik

PY - 2021/12

Y1 - 2021/12

N2 - Background & Aims While several anthropometric measures predict liver disease, the waist-hip ratio (WHR) has shown superiority in previous studies. We analysed independent and joint associations of waist circumference (WC) and hip circumference (HC) with liver disease and liver-related risk factors. Methods Cross-sectional study (n = 6619) and longitudinal cohort (n = 40 923) comprised individuals from Health 2000 and FINRISK 1992-2012 studies. Prevalent and viral liver diseases were excluded. Longitudinal cohort was linked with national healthcare registers for severe incident liver disease. Linear regression and Cox proportional hazards models were used to analyse anthropometric, lifestyle, metabolic and bioimpedance-related parameters; liver enzymes; and 59 liver-related genetic risk variants. Results WC and HC showed independent and opposite associations with both liver enzymes and incident liver disease among men (HR for liver disease: WC, 1.07, 95% CI 1.03-1.11; HC, 0.96, 95% CI 0.92-0.99; P-range .04 to

AB - Background & Aims While several anthropometric measures predict liver disease, the waist-hip ratio (WHR) has shown superiority in previous studies. We analysed independent and joint associations of waist circumference (WC) and hip circumference (HC) with liver disease and liver-related risk factors. Methods Cross-sectional study (n = 6619) and longitudinal cohort (n = 40 923) comprised individuals from Health 2000 and FINRISK 1992-2012 studies. Prevalent and viral liver diseases were excluded. Longitudinal cohort was linked with national healthcare registers for severe incident liver disease. Linear regression and Cox proportional hazards models were used to analyse anthropometric, lifestyle, metabolic and bioimpedance-related parameters; liver enzymes; and 59 liver-related genetic risk variants. Results WC and HC showed independent and opposite associations with both liver enzymes and incident liver disease among men (HR for liver disease: WC, 1.07, 95% CI 1.03-1.11; HC, 0.96, 95% CI 0.92-0.99; P-range .04 to

KW - BODY-COMPOSITION

KW - CARDIOVASCULAR RISK

KW - FATTY LIVER

KW - INSULIN-RESISTANCE

KW - NORMAL-WEIGHT

KW - OBESITY

KW - PREDICTS DEVELOPMENT

KW - RATIO

KW - SKELETAL-MUSCLE MASS

KW - WHOLE-BODY

KW - anthropometric measures

KW - body mass index

KW - fat

KW - sarcopenia

KW - waist-hip ratio

KW - 3121 General medicine, internal medicine and other clinical medicine

U2 - 10.1111/liv.15053

DO - 10.1111/liv.15053

M3 - Article

SN - 1478-3223

VL - 41

SP - 2903

EP - 2913

JO - Liver International

JF - Liver International

IS - 12

ER -