In vivo small animal SPECT/CT Imaging Laboratory

Utrustning/facilitet: Utrustning

  • Plats

    Viikinkaari 1

    Biocenter 3

    Helsinki

    Finland

Utrustningsinformation

Text

Single photon emission computed tomography/computed tomography (SPECT/CT) has wide applicability in modern bioscience. It is based on detecting a radioactive labelled tracer in the body of a small animal (rodent) in time in vivo in an non-invasive manner. It is one of the most powerful methods to visualize distribution and elimination of drugs in the body and to study drug-targeting methods aiming at tissue specific drug delivery, including gene transfer in vivo. It can be used to monitor status of lesions in disease models, in vivo receptor binding kinetics, tumour growth and eradication by treatment, metabolic activity of the tissues, and survival and fate of transplanted cells. Important advantages of this technology are, on one hand, the lack of limits in tissue depth for detection, the versatility of radiotracers’ chemistry, and the commercial availability of relatively large number of radiopharmaceuticals for widespread applications. Surpassed in detection limits only by fluorescence-based methods, which can detect tracers at concentrations almost to 2 or 3 orders of magnitude lower than SPECT, but do not offer high quantitation, linearity or enough tissue depth, which is true in the case of SPECT. The combination of SPECT with CT, makes accurate anatomic localisation of the tracer and offers 3-D imaging capability. SPECT/CT has the benefit to image the entire body in real time, in vivo, longitudinally in the same animal, which translates not only in ethical convenience and statistical effectiveness, but also in better cost-effectiveness compared with other non-imaging classical strategies.

Detaljer

NamnIn vivo small animal SPECT/CT Imaging Laboratory
Anskaffningsdatum14/12/2015

Forskningsinfrastrukturens typ

  • !!Equipment
  • !!Service

Vetenskapsgrenar

  • 317 Farmaci

ESFRI tematiska områden

  • !!Biological and Medical Sciences

HU forskningsinfrastruktur klassificering

  • Central serviceenhet

Forskningsresultat

Radiolabeled Molecular Imaging Probes for the in Vivo Evaluation of Cellulose Nanocrystals for Biomedical Applications

Imlimthan, S., Otaru, S., Keinänen, O., Correia, A., Lintinen, K., Almeida Santos, H., Airaksinen, A., Kostiainen, M. & Sarparanta, M., feb 2019, I : Biomacromolecules. 20, 2, s. 674–683 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Abscopal Effect in Non-injected Tumors Achieved with Cytokine-Armed Oncolytic Adenovirus

Havunen, R., Santos, J. M., Sorsa, S., Rantapero, T., Lumen, D., Siurala, M., Airaksinen, A. J., Cervera-Carrascon, V., Tähtinen, S., Kanerva, A. & Hemminki, A., 21 dec 2018, I : Molecular Therapy - Oncolytics. 11, s. 109-121 13 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Fil

Adenoviral Delivery of Tumor Necrosis Factor-alpha and Interleukin-2 Enables Successful Adoptive Cell Therapy of Immunosuppressive Melanoma

Siurala, M., Havunen, R., Saha, D., Lumen, D., Airaksinen, A. J., Tähtinen, S., Cervera-Carrascon, V., Bramante, S., Parviainen, S., Vaha-Koskela, M., Kanerva, A. & Hemminki, A., aug 2016, I : Molecular therapy. 24, 8, s. 1435-1443 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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