Biomolecular Complex Purification Core Facility (Biocomplex)

Utrustning/facilitet: Central servicefacilitet

  • Plats

    Viikinkaari 9

    Biocenter 1 (B-building, 6th floor]






Biocomplex is specialized in macromolecular sample preparation and purification for functional and structural studies using preparative ultracentrifugation, asymmetrical flow field-flow fractionation, and monolithic chromotography. Biocomplex is part of the national Instruct-FI network and Biocenter Finland. Biocomplex, cryo-EM, NMR, and protein crystallization core facilities form Instruct-HiLIFE platform, which operates both at the Faculty of Biological and Environmental Sciences and Institute of Biotechnology (HiLIFE). Instruct-FI in on the Finnish Research Infrastructure road map 2014-2020. Instruct-FI coordinates the structural biology research infrastructure activities in Finland and operates as the Structural Biology Programme of the Biocenter Finland.
Instruct-ERIC is a pan-European research infrastructure in structural biology, making high-end technologies and methods available to all European researchers. Instruct services and expertise are provided in the Instruct Centres. The main experimental technologies are complementary, and increasingly link detailed atomic structure with cellular context. Services include sample preparation methods, biomolecular analysis techniques, and 3D structural analysis, Biocomplex operated as one of the Instruct Centres in 2009-2017 (ICVIR, Instruct Centre for Virus Production).

Forskningsinfrastrukturens typ

  • !!Service
  • !!Equipment


  • 1182 Biokemi, cell- och molekylärbiologi
  • 1183 Växtbiologi, mikrobiologi, virologi
  • 119 Övrig naturvetenskap

ESFRI tematiska områden

  • !!Biological and Medical Sciences

HU forskningsinfrastruktur klassificering

  • Central serviceenhet


Analysis of spounaviruses as a case study for the overdue reclassification of tailed phages

Barylski, J., Enault, F., Dutilh, B. E., Schuller, M. B. P., Edwards, R. A., Gillis, A., Klumpp, J., Knezevic, P., Krupovic, M., Kuhn, J. H., Lavigne, R., Oksanen, H. M., Sullivan, M. B., Jang, H. B., Simmonds, P., Aiewsakun, P., Wittmann, J., Tolstoy, I., Brister, J. R., Kropinki, A. & 1 andra, Adriaenssens, E. M., jan 2020, I : Systematic Biology. 69, 1, s. 110-123 14 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Öppen tillgång

Enzymatically synthesized 2'-fluoro-modified Dicer-substrate siRNA swarms against herpes simplex virus demonstrate enhanced antiviral efficacy and low cytotoxicity

Levanova, A., Kalke, K., Lund, L., Sipari, N., Sadeghi, M., Nyman, M., Paavilainen, H., Hukkanen, V. & Poranen, M., okt 2020, I : Antiviral Research. 182, 8 s., 104916.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

ICTV Virus Taxonomy Profile: Finnlakeviridae

Mäntynen, S. S., Laanto, E., Sundberg, L-R., Poranen, M., Oksanen, H. M. & ICTV Report Consortium, 2020, (!!Accepted/In press) I : Journal of General Virology.

Forskningsoutput: TidskriftsbidragÖversiktsartikelVetenskapligPeer review


Asymmetrical flow field-flow fractionation and virus applications

Katri Eskelin (!!Speaker)

24 feb 2020

Aktivitet: Typer för tal eller presentation!!Oral presentation

Instruct-ERIC Access Committee (Extern organisation)

Hanna M Oksanen (Medlem)

2020 → …

Aktivitet: MedlemskapstyperMedlemskap eller annan roll i granskningskommitté

Instruct-ERIC Centre Finland (Extern organisation)

Hanna M Oksanen (Expert)

2019 → …

Aktivitet: MedlemskapstyperMedlemskap eller annan roll i forskningsnätverk