• PL 56 (Viikinkaari 5E), Biocenter 2

    00014 HELSINGIN YLIOPISTO

    Finland

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Acetate-Derived Metabolites from the Brown Alga Lobophora variegata

Gutiérrez-Cepeda, A., Fernández, J. J., Norte, M., Montalvão, S., Tammela, P. & Souto, M. L., jul 2015, I : Journal of Natural Products. 78, 7, s. 1716-1722 7 s.

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Acetylcholinesterase inhibitory guided fractionation of Melissa officinalis L.

Dastmalchi, K., Ollilainen, V., Lackman, P., af Gennas, G. B., Dorman, H. J. D., Jarvinen, P. P., Yli-Kauhaluoma, J. & Hiltunen, R., 2009, I : Bioorganic & Medicinal Chemistry. 17, 2, s. 867-871 5 s.

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Aggregating Behavior of Phenolic Compounds - A Source of False Bioassay Results?

Pohjala, L. & Tammela, P., 2012, I : Molecules. 17, 9, s. 10774-10790 17 s.

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Analyzing user-generated online content for drug discovery: Development and use of MedCrawler

Helfenstein, A. & Tammela, P., 15 apr 2017, I : Bioinformatics. 33, 8, s. 1205-1209 5 s.

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A new cell-based AI-2-mediated quorum sensing interference assay in screening of LsrK-targeted inhibitors

Gatta, V., Tomašič, T., Ilaš, J., Zidar, N., Peterlin Mašič, L., Barančoková, M., Frlan, R., Anderluh, M., Kikelj, D. & Tammela, P., 6 feb 2020, I : ChemBioChem : a European journal of chemical biology.

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An optimised series of substituted N-phenylpyrrolamides as DNA gyrase B inhibitors

Benetto Tiz, D., Skok, Ž., Durcik, M., Tomašič, T., Peterlin Mašič, L., Ilaš, J., Draskovits, G., Révész, T., Nyerges, Á., Pál, C., Cruz, C. D., Tammela, P. S. M., Žigon, D., Kikelj, D. & Zidar, N., 1 apr 2019, I : European Journal of Medicinal Chemistry. 167, s. 269-290 22 s.

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Antibacterial and antioxidative properties of different parts of garden rhubarb, blackcurrant, chokeberry and blue honeysuckle

Raudsepp, P., Koskar, J., Anton, D., Meremäe, K., Kapp, K., Laurson, P., Bleive, U., Kaldmäe, H., Roasto, M. & Püssa, T., 30 mar 2019, I : Journal of the Science of Food and Agriculture. 99, 5, s. 2311-2320 10 s.

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Antibacterial profiling of abietane-type diterpenoids

Helfenstein, A., Vahermo, M. M. A., Nawrot, D. A., Demirci, F., İşcan, G., Krogerus, S., Yli-Kauhaluoma, J. T., Moreira, V. M. & Tammela, P. S. M., jan 2017, I : Bioorganic & Medicinal Chemistry. 25, 1, s. 132-137 6 s.

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Antidepressant Drugs Transactivate TrkB Neurotrophin Receptors in the Adult Rodent Brain Independently of BDNF and Monoamine Transporter Blockade.

Rantamäki, T., Vesa, L. K., Antila, H., Di Lieto, A., Tammela, P., Schmitt, A., Lesch, K-P., Rios, M. & Castrén, E., jun 2011, I : PLoS One. 6, 6, s. e20567 8 s.

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Anti-influenza virus activity of benzo[d]thiazoles that target heat shock protein 90

Lamut, A., Gjorgjieva, M., Naesens, L., Liekens, S., Lillsunde, K-E., Tammela, P., Kikelj, D. & Tomašič, T., 8 mar 2020, (!!Accepted/In press) I : Bioorganic Chemistry.

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Antimicrobial activity of the marine alkaloids, clathrodin and oroidin, and their synthetic analogues

Zidar, N., Montalvão, S., Hodnik, Z., Nawrot, D. A., Zula, A., Ilas, J., Kikelj, D., Tammela, P. & Peterlin Masic, L., 2014, I : Marine Drugs. 12, 2, s. 940-963 24 s.

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Antimicrobial assay optimization and validation for HTS in 384-well format using a bioluminescent E. coli K-12 strain

Nybond, S., Karp, M. & Tammela, P., 2013, I : European Journal of Pharmaceutical Sciences. 49, 4, s. 782-789 8 s.

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Antimicrobial Colloidal Silver-Lignin Particles via Ion- and Solvent Exchange

Sakari Lintinen, K., Luiro, S., Figueiredo, P., Sakarinen, E., Mousavi, Z., Seitsonen, J., N. S. Rivière, G., Mattinen, U., Niemelä, M., Tammela, P., Österberg, M., Johansson, L-S., Bobacka, J., Santos, H. A. & A. Kostiainen, M., 16 sep 2019, I : ACS Sustainable Chemistry & Engineering. 7, 18, s. 15297-15303 7 s.

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Assessing the data quality in predictive toxicology using a panel of cell lines and cytotoxicity assays

Pohjala, L., Tammela, P., Samanta, S., Yli-Kauhaluoma, J. & Vuorela, P., 2007, I : Analytical Biochemistry. 362, 2, s. 221-228

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Avaliação do teor de lipídios em queijos Minas Frescal industrializados e artesanais e em ricotas comercializados na região de Botucatu/SP

Cruz, CD. & Gomes, M. I., 2001, I : Instituto Adolfo Lutz. Revista. 60, 2, s. 109-112 4 s.

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A versatile strategy for the synthesis of 4,5-dihydroxy-2,3-pentadione (DPD) and related compounds as potential modulators of bacterial quorum sensing

Stotani, S., Gatta, V., Medda, F., Padmanaban, M., Karawajzyk, A., Tammela, P. S. M., Giordanetto, F., Tzalis, D. & Collina, S., 6 okt 2018, I : Molecules. 23, 10, 22 s., 2545.

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Baltic cyanobacteria - a source of biologically active compounds

Mazur-Marzec, H., Błaszczyk, A., Felczykowska, A., Hohlfeld, N., Kobos, J., Toruńska-Sitarz, A., Devi, P., Montalvao, S., D'Souza, L., Tammela, P., Mikosik, A., Bloch, S., Nejman-Faleńczyk, B. & Węgrzyn, G., jul 2015, I : European Journal of Phycology. 50, 3, s. 343-360 18 s.

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Betulin-derived compounds as inhibitors of alphavirus replication

Pohjala, L., Alakurtti, S., Ahola, T., Yli-Kauhaluoma, J. & Tammela, P., 2009, I : Journal of Natural Products. 72, 11, s. 1917-1926 10 s.

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Bioactive cembrane derivatives from the Indian Ocean soft coral, Sinularia kavarattiensis

Lillsunde, K-E., Festa, C., Adel, H., De Marino, S., Lombardi, V., Tilvi, S., Nawrot, D., Zampella, A., D'Souza, L., D'Auria, M. V. & Tammela, P., 3 jul 2014, I : Marine Drugs. 12, 7, s. 4045-4068 24 s.

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Bioluminescent whole-cell reporter gene assays as screening tools in the identification of antimicrobial natural product extracts

Nybond, S. C. S., Karp, M., Yrjönen, T. J. & Tammela, P. S. M., maj 2015, I : Journal of Microbiological Methods. 114, s. 54-56 3 s.

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Cell-based bioreporter assay coupled to HPLC micro-fractionation in the evaluation of antimicrobial properties of the basidiomycete fungus Pycnoporus cinnabarinus

Järvinen, P. P., Nybond, S. C. S., Marcourt, L., Queiroz, E. F., Wolfender, J-L., Mettälä, A. H., Karp, M., Vuorela, H. J., Vuorela, P. M., Hatakka, A. I. & Tammela, P. S. M., 2016, I : Pharmaceutical Biology. 54, 6, s. 1108-1115 8 s.

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Commercial peppermint (Mentha × piperita L.) teas: Antichlamydial effect and polyphenolic composition

Kapp, K., Hakala, E., Orav, A., Pohjala, L., Vuorela, P., Püssa, T., Vuorela, H. & Raal, A., 2013, I : Food Research International. 53, 2, s. 758-766 9 s.

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Comparison of transgenic Gerbera hybrida lines and traditional varieties shows no differences in cytotoxicity or metabolic fingerprints

Ainasoja, M., Pohjala, L., Tammela, P., Somervuo, P., Vuorela, P. & Teeri, T., 2008, I : Transgenic Research. 17, 5, s. 793-803 11 s.

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Defining conditions for biofilm inhibition and eradication assays for Gram-positive clinical reference strains

Cruz, C. D., Shah, S. & Tammela, P., 3 nov 2018, I : BMC Microbiology. 18, 9 s., 173.

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Design, Synthesis and Biological Evaluation of 1-Ethyl-3-(thiazol-2-yl)urea Derivatives as Escherichia coli DNA Gyrase Inhibitors

Tomašič, T., Barančoková, M., Zidar, N., Ilaš, J., Tammela, P. S. M. & Kikelj, D., 3 jan 2018, I : Archiv der Pharmazie : Chemistry in life sciences. 351, 1, 16 s., e1700333.

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Design, synthesis and biological evaluation of 4,5-dibromo-N-(thiazol-2-yl)-1H-pyrrole-2-carboxamide derivatives as novel DNA gyrase inhibitors

Tomašič, T., Mirt, M., Barančoková, M., Ilaš, J., Zidar, N., Tammela, P. S. M. & Kikelj, D., 1 jan 2017, I : Bioorganic & Medicinal Chemistry. 25, 1, s. 338-349 12 s.

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Design, synthesis and biological evaluation of novel DNA gyrase Inhibitors and their siderophore mimic conjugates

Lamut, A., Cruz, C. D., Skok, Ž., Barančoková, M., Zidar, N., Zega, A., Peterlin Mašič, L., Ilaš, J., Tammela, P., Kikelj, D. & Tomašič, T., 2020, I : Bioorganic Chemistry. 95, 13 s., 103550.

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Design, Synthesis and Evaluation of Novel Tyrosine-Based DNA Gyrase B Inhibitors

Cotman, A., Trampuž, M., Brvar, M., Kikelj, D., Ilaš, J., Peterlin-Mašič, L., Montalvao, S. I. G. H., Tammela, P. S. M. & Frlan, R., aug 2017, I : Archiv der Pharmazie : Chemistry in life sciences. 350, 8, 16 s., 1700087 .

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Development and validation of a time-resolved fluorometric immunoassay for screening of antichlamydial activity using a genus-specific europium-conjugated antibody

Tammela, P., Alvesalo, J., Riihimaki, L., Airenne, S., Leinonen, M., Hurskainen, P., Enkvist, K. & Vuorela, P., 2004, I : Analytical Biochemistry. 333, 1, s. 39-48 10 s.

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Development of the CELLOP optimisation model for plant cell cultivation

Eeva, M., Vuorela, P., Tammela, P., Nyman, M., Ojala, S., Fagerstedt, K., Haario, H. & Vuorela, H., 2007, I : Biologia Plantarum. 51, 1, s. 27-33 7 s.

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Discovering protein kinase C active plants growing in Finland utilizing automated bioassay combined to LC/MS

Galkin, A., Jokela, J., Wahlsten, M., Tammela, P., Sivonen, K. & Vuorela, P., 2009, I : Natural Product Communications. 4, 1, s. 139-142 4 s.

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Discovery of 4,5,6,7-tetrahydrobenzo[1,2-d]thiazoles as novel DNA gyrase inhibitors targeting the ATP-binding site

Tomašič, T., Katsamakas, S., Hodnik, Ž., Ilaš, J., Brvar, M., Solmajer, T., Montalvao, S., Tammela, P., Banjanac, M., Ergović, G., Anderluh, M., Peterlin Mašič, L. & Kikelj, D., 23 jul 2015, I : Journal of Medicinal Chemistry. 58, 14, s. 5501-5521 21 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Discovery of bentzothiazole scaffold-based DNA gyrase B inhibitors

Gjorgjieva, M., Tomašič, T., Barančokova, M., Katsamakas, S., Ilaš, J., Tammela, P., Peterlin Mašič, L. & Kikelj, D., okt 2016, I : Journal of Medicinal Chemistry. 59, 19, s. 8941-8954 14 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Discovery of dual binding site acetylcholinesterase inhibitors identified by pharmacophore modeling and sequential virtual screening techniques.

Gupta, S., Fallarero, A., Järvinen (née Oinonen), P., Karlsson, D., Johnson, M. S., Vuorela, P. & Mohan, C. G., feb 2011, I : Bioorganic & Medicinal Chemistry Letters. 21, 4, s. 1105-1112 8 s.

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Discovery of Dual Binding Site Acetylcholinesterase Inhibitors Identified by Pharmacophore Modelling and Sequential Virtual Screening Techniques

Gupta, S., Fallarero, A., Järvinen, P., Karlsson, D., Johnson, M. S., Vuorela, P. M. & Mohan, C. G., 2011, I : Bioorganic & Medicinal Chemistry Letters. 21, 4, s. 1106-1112

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Discovery of substituted oxadiazoles as a novel scaffold for DNA gyrase inhibitors

Jakopin, Z., Ilas, J., Barancokova, M., Brvar, M., Tammela, P., Dolenc, M. S., Tomasic, T. & Kikelj, D., 21 apr 2017, I : European Journal of Medicinal Chemistry. 130, s. 171-184 14 s.

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DPD-inspired discovery of novel LsrK kinase inhibitors: an opportunity to fight antimicrobial resistance

Stotani, S., Gatta, V., Medarametla, P., Padmanaban, M., Karawajzyk, A., Giordanetto, F., Tammela, P., Laitinen, T., Poso, A., Tzalis, D. & Collina, S., 14 mar 2019, I : Journal of Medicinal Chemistry. 62, 5, s. 2720-2737 18 s.

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Effect of differentiation on endocytic profiles of endothelial and epithelial cell culture models

Ilina, P., Partti, S., Niklander, J., Ruponen, M., Lou, Y-R. & Yliperttula, M., 1 mar 2015, I : Experimental Cell Research. 332, 1, s. 89-101 13 s.

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Ent-kauren-19-oic acid derivatives from the stem bark of Croton pseudopulchellus Pax

Langat, M. K., Crouch, N. R., Pohjala, L., Tammela, P., Smith, P. J. & Mulholland, D. A., 2012, I : Phytochemistry Letters. 5, 3, s. 414-418 5 s.

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Exploring Marine Resources for Bioactive Compounds

Kiuru, P., D'Auria, M. V., Muller, C. D., Tammela, P., Vuorela, H. & Yli-Kauhaluoma, J., sep 2014, I : Planta Medica. 80, 14, s. 1234-1246 13 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Exploring the structure-activity relationships of ABCC2 modulators using a screening approach

Wissel, G., Kudryavtsev, P., Ghemtio, L., Tammela, P., Wipf, P., Yliperttula, M., Finel, M., Urtti, A., Kidron, H. & Xhaard, H., 2015, I : Bioorganic & Medicinal Chemistry. 23, 13, s. 3513-3525 13 s.

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Fabrication of concave micromirrors for single cell imaging via controlled over-exposure of organically modified ceramics in single step lithography

Bonabi, A., Cito, S., Tammela, P., Jokinen, V. & Sikanen, T., maj 2017, I : Biomicrofluidics. 11, 3, 11 s., 034118.

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Genetic blockage of endocytic pathways reveals differences in the intracellular processing of non-viral gene delivery systems

Ilina, P., Hyvonen, Z., Saura, M., Sandvig, K., Yliperttula, M. & Ruponen, M., 10 nov 2012, I : Journal of Controlled Release. 163, 3, s. 385-395 11 s.

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Hyaluronic Acid Graft Copolymers with Cleavable Arms as Potential Intravitreal Drug Delivery Vehicles

Borke, T., Najberg, M., Ilina, P., Bhattacharya, M., Urtti, A., Tenhu, H. & Hietala, S., 1 jan 2018, I : Macromolecular Bioscience. 18, 1, 13 s., 1700200.

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Hydrophobic derivatives of 5-(hydroxymethyl)isophthalic acid that selectively induce apoptosis in leukemia cells but not in fibroblasts

Galkin, A., Surakka, A., Boije af Gennäs, G., Ruotsalainen, T., Kreander, K., Tammela, P., Sivonen, K., Yli-Kauhaluoma, J. & Vuorela, P., 2008, I : Drug Development Research. 69, 4, s. 185-195 11 s.

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Identification and characterization of approved drugs and drug-like compounds as covalent Escherichia coli ClpP inhibitors

Sassetti, E., Cruz, C. D., Tammela, P., Winterhalter, M., Augustyns, K., Gribbon, P. & Windshügel, B., 1 jun 2019, I : International Journal of Molecular Sciences. 20, 11, 13 s., 2686.

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Identification of COMT and ErmC inhibitors by using a microplate assay in combination with library focusing by virtual screening

Kreander, K., Kurkela, M., Siiskonen, A., Vuorela, P. & Tammela, P., 2006, I : Pharmazie. 61, 3, s. 247-248 2 s.

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Inhibition of Breast Cancer Resistance Protein and Multidrug Resistance Associated Protein 2 by Natural Compounds and Their Derivatives

Sjöstedt, N., Holvikari, K., Tammela, P. & Kidron, H., jan 2017, I : Molecular Pharmaceutics. 14, 1, s. 135-146 12 s.

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Inhibition of Hepatitis C replication by targeting the molecular chaperone Hsp90 - synthesis and biological evaluation of 4,5,6,7-tetrahydrobenzo[1,2-d]thiazole derivatives

Lillsunde, K-E. M., Tomašič, T., Schult, P., Lohmann, V., Kikelj, D. & Tammela, P., 5 feb 2019, I : ChemMedChem : chemistry enabling drug discovery.. 14, 3, s. 334-342 9 s.

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Inhibition of Nonessential Bacterial Targets: Discovery of a Novel Serine O-Acetyltransferase Inhibitor

Pinto de Magalhães, J., Franko, N., Raboni, S., Annunziato, G., Tammela, P., Bruno, A., Bettati, S., Mozzarelli, A., Pieroni, M., Cambanini, B. & Costantino, G., 13 feb 2020, I : ACS Medicinal Chemistry Letters.

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