• PL 56 (Viikinkaari 5E), Biocenter 2

    00014 HELSINGIN YLIOPISTO

    Finland

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2015

Integrated in vitro - in silico screening strategy for the discovery of antibacterial compounds

Nybond, S., Ghemtio, L., Nawrot, D., Karp, M., Xhaard, H. & Tammela, P., 2015, I : Assay and drug development technologies. 13, 1, s. 25-33 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

N-Phenyl-4,5-dibromopyrrolamides and N-phenylindolamides as ATP competitive DNA gyrase B Inhibitors: Design, synthesis, and evaluation

Zidar, N., Macut, H., Tomašič, T., Brvar, M., Montalvao, S., Tammela, P., Solmajer, T., Peterlin Mašič, L., Ilaš, J. & Kikelj, D., 2015, I : Journal of Medicinal Chemistry. 58, 15, s. 6179-6194 16 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Screening_mgmt: A Python Module for Managing Screening Data

Helfenstein, A. & Tammela, P., feb 2015, I : Journal of Laboratory Automation. 20, 1, s. 56-59 4 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Synthesis and biological evaluation of 2-arylbenzimidazoles targeting Leishmania donovani

Keurulainen, L., Siiskonen, A., Nasereddin, A., Kopelyanskiy, D., Sacerdoti-Sierra, N., Leino, T. O., Tammela, P., Yli-Kauhaluoma, J., Jaffe, C. L. & Kiuru, P., 1 maj 2015, I : Bioorganic & Medicinal Chemistry Letters. 25, 9, s. 1933-1937 5 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2014

Antimicrobial activity of the marine alkaloids, clathrodin and oroidin, and their synthetic analogues

Zidar, N., Montalvão, S., Hodnik, Z., Nawrot, D. A., Zula, A., Ilas, J., Kikelj, D., Tammela, P. & Peterlin Masic, L., 2014, I : Marine Drugs. 12, 2, s. 940-963 24 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Bioactive cembrane derivatives from the Indian Ocean soft coral, Sinularia kavarattiensis

Lillsunde, K-E., Festa, C., Adel, H., De Marino, S., Lombardi, V., Tilvi, S., Nawrot, D., Zampella, A., D'Souza, L., D'Auria, M. V. & Tammela, P., 3 jul 2014, I : Marine Drugs. 12, 7, s. 4045-4068 24 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Exploring Marine Resources for Bioactive Compounds

Kiuru, P., D'Auria, M. V., Muller, C. D., Tammela, P., Vuorela, H. & Yli-Kauhaluoma, J., sep 2014, I : Planta Medica. 80, 14, s. 1234-1246 13 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Screening and Characterisation of Antimicrobial Properties of Semisynthetic Betulin Derivatives

Haque, S., Nawrot, D. A., Alakurtti, S., Ghemtio, L., Yli-Kauhaluoma, J. & Tammela, P., 17 jul 2014, I : PLoS One. 9, 7, 9 s., e102696.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Utilization of in situ ELISA method for examining Trk receptor phosphorylation in cultured cells

Antila, H., Autio, H., Turunen, L., Harju, K., Tammela, P., Wennerberg, K., Yli-Kauhaluoma, J., Huttunen, H. J., Castren, E. & Rantamaki, T., 30 jan 2014, I : Journal of Neuroscience Methods. 222, s. 142-146 5 s.

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2013

Antimicrobial assay optimization and validation for HTS in 384-well format using a bioluminescent E. coli K-12 strain

Nybond, S., Karp, M. & Tammela, P., 2013, I : European Journal of Pharmaceutical Sciences. 49, 4, s. 782-789 8 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Commercial peppermint (Mentha × piperita L.) teas: Antichlamydial effect and polyphenolic composition

Kapp, K., Hakala, E., Orav, A., Pohjala, L., Vuorela, P., Püssa, T., Vuorela, H. & Raal, A., 2013, I : Food Research International. 53, 2, s. 758-766 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2012

Aggregating Behavior of Phenolic Compounds - A Source of False Bioassay Results?

Pohjala, L. & Tammela, P., 2012, I : Molecules. 17, 9, s. 10774-10790 17 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Ent-kauren-19-oic acid derivatives from the stem bark of Croton pseudopulchellus Pax

Langat, M. K., Crouch, N. R., Pohjala, L., Tammela, P., Smith, P. J. & Mulholland, D. A., 2012, I : Phytochemistry Letters. 5, 3, s. 414-418 5 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Genetic blockage of endocytic pathways reveals differences in the intracellular processing of non-viral gene delivery systems

Ilina, P., Hyvonen, Z., Saura, M., Sandvig, K., Yliperttula, M. & Ruponen, M., 10 nov 2012, I : Journal of Controlled Release. 163, 3, s. 385-395 11 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Kaubanduslike piparmünditeede koostis ja mõju Chlamydia pneumonia`le

Kapp, K., 2012, I : Eesti rohuteadlane.. 6, s. 21-22

Forskningsoutput: TidskriftsbidragArtikelProfessionell

γ-Aminobutyric Acid Type A (GABAA) Receptor Activation Modulates Tau Phosphorylation

Nykänen, N-P., Kysenius, K. J., Sakha, P., Tammela, P. & Huttunen, H. J., 24 feb 2012, I : Journal of Biological Chemistry. 287, 9, s. 6743-6752 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2011

Antidepressant Drugs Transactivate TrkB Neurotrophin Receptors in the Adult Rodent Brain Independently of BDNF and Monoamine Transporter Blockade.

Rantamäki, T., Vesa, L. K., Antila, H., Di Lieto, A., Tammela, P., Schmitt, A., Lesch, K-P., Rios, M. & Castrén, E., jun 2011, I : PLoS One. 6, 6, s. e20567 8 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Discovery of dual binding site acetylcholinesterase inhibitors identified by pharmacophore modeling and sequential virtual screening techniques.

Gupta, S., Fallarero, A., Järvinen (née Oinonen), P., Karlsson, D., Johnson, M. S., Vuorela, P. & Mohan, C. G., feb 2011, I : Bioorganic & Medicinal Chemistry Letters. 21, 4, s. 1105-1112 8 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Discovery of Dual Binding Site Acetylcholinesterase Inhibitors Identified by Pharmacophore Modelling and Sequential Virtual Screening Techniques

Gupta, S., Fallarero, A., Järvinen, P., Karlsson, D., Johnson, M. S., Vuorela, P. M. & Mohan, C. G., 2011, I : Bioorganic & Medicinal Chemistry Letters. 21, 4, s. 1106-1112

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Inhibitors of Alphavirus Entry and Replication Identified with a Stable Chikungunya Replicon Cell Line and Virus-Based Assays

Pohjala, L., Utt, A., Varjak, M., Lulla, A., Merits, A., Ahola, T. & Tammela, P., 19 dec 2011, I : PLoS One. 6, 12, s. e28923 13 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Potency determinations of acetylcholinesterase inhibitors using Ellman's reagent-based assay in screening: Effect of assay variants

Järvinen, P., Vuorela, P., Hatakka, A. & Fallarero, A., 2011, I : Analytical Biochemistry. 408, 1, s. 166-168 3 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Triterpenoid Acids and Lactones from the Leaves of Fadogia tetraquetra var. tetraquetra (Rubiaceae)

Mulholland, D. A., Mohammed, A. M. A., Coombes, P. H., Haque, S., Pohjala, L., Tammela, P. & Crouch, N. R., 2011, I : Natural Product Communications. 6, 11, s. 1573-1576

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2009

Acetylcholinesterase inhibitory guided fractionation of Melissa officinalis L.

Dastmalchi, K., Ollilainen, V., Lackman, P., af Gennas, G. B., Dorman, H. J. D., Jarvinen, P. P., Yli-Kauhaluoma, J. & Hiltunen, R., 2009, I : Bioorganic & Medicinal Chemistry. 17, 2, s. 867-871 5 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Betulin-derived compounds as inhibitors of alphavirus replication

Pohjala, L., Alakurtti, S., Ahola, T., Yli-Kauhaluoma, J. & Tammela, P., 2009, I : Journal of Natural Products. 72, 11, s. 1917-1926 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Discovering protein kinase C active plants growing in Finland utilizing automated bioassay combined to LC/MS

Galkin, A., Jokela, J., Wahlsten, M., Tammela, P., Sivonen, K. & Vuorela, P., 2009, I : Natural Product Communications. 4, 1, s. 139-142 4 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2008

Comparison of transgenic Gerbera hybrida lines and traditional varieties shows no differences in cytotoxicity or metabolic fingerprints

Ainasoja, M., Pohjala, L., Tammela, P., Somervuo, P., Vuorela, P. & Teeri, T., 2008, I : Transgenic Research. 17, 5, s. 793-803 11 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Hydrophobic derivatives of 5-(hydroxymethyl)isophthalic acid that selectively induce apoptosis in leukemia cells but not in fibroblasts

Galkin, A., Surakka, A., Boije af Gennäs, G., Ruotsalainen, T., Kreander, K., Tammela, P., Sivonen, K., Yli-Kauhaluoma, J. & Vuorela, P., 2008, I : Drug Development Research. 69, 4, s. 185-195 11 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Listeria monocytogenes: UM AGENTE INFECCIOSO AINDA POUCO CONHECIDO NO BRASIL

Cruz, CD., Destro, M. T. & Martinez, M. B., 2008, I : Alimentos e Nutricao. 19, 2, s. 195-206 12 s.

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2007

Assessing the data quality in predictive toxicology using a panel of cell lines and cytotoxicity assays

Pohjala, L., Tammela, P., Samanta, S., Yli-Kauhaluoma, J. & Vuorela, P., 2007, I : Analytical Biochemistry. 362, 2, s. 221-228

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Development of the CELLOP optimisation model for plant cell cultivation

Eeva, M., Vuorela, P., Tammela, P., Nyman, M., Ojala, S., Fagerstedt, K., Haario, H. & Vuorela, H., 2007, I : Biologia Plantarum. 51, 1, s. 27-33 7 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2006

Identification of COMT and ErmC inhibitors by using a microplate assay in combination with library focusing by virtual screening

Kreander, K., Kurkela, M., Siiskonen, A., Vuorela, P. & Tammela, P., 2006, I : Pharmazie. 61, 3, s. 247-248 2 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Inhibitory effect of dietary phenolic compounds on Chlamydia pneumoniae in cell cultures

Alvesalo, J., Vuorela, H., Tammela, P., Leinonen, M., Saikku, P. & Vuorela, P., 2006, I : Biochemical Pharmacology. 71, 6, s. 735-741

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

In-vitro mutagenic potential and effect on permeability of co-administered drugs across Caco-2 cell monolayers of Rubus idaeus and its fortified fractions

Kreander, K., Galkin, A., Vuorela, S., Tammela, P., Laitinen, L., Heinonen, M. & Vuorela, P., 2006, I : Journal of Pharmacy and Pharmacology. 58, 11, s. 1545-1552

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Similarity based virtual screening: a tool for targeted library design

Alvesalo, J., Siiskonen, A., Vainio, M., Tammela, P. & Vuorela, P., 2006, I : Journal of Medicinal Chemistry. 49, 7, s. 2353-2356

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2004

Development and validation of a time-resolved fluorometric immunoassay for screening of antichlamydial activity using a genus-specific europium-conjugated antibody

Tammela, P., Alvesalo, J., Riihimaki, L., Airenne, S., Leinonen, M., Hurskainen, P., Enkvist, K. & Vuorela, P., 2004, I : Analytical Biochemistry. 333, 1, s. 39-48 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2003

In vitro assay for human toxicity of cereulide, the emetic mitochondrial toxin produced by food poisoning Bacillus cereus

Jääskeläinen, E., Teplova, V., Andersson, M., Andersson, L. C., Tammela, P., Andersson, M., Pirhonen, T., Saris, N-E., Vuorela, P. & Salkinoja-Salonen, M. S., okt 2003, I : Toxicology in Vitro. 17, 5-6, s. 737-744 8 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2001

Avaliação do teor de lipídios em queijos Minas Frescal industrializados e artesanais e em ricotas comercializados na região de Botucatu/SP

Cruz, CD. & Gomes, M. I., 2001, I : Instituto Adolfo Lutz. Revista. 60, 2, s. 109-112 4 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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