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2020

A new cell-based AI-2-mediated quorum sensing interference assay in screening of LsrK-targeted inhibitors

Gatta, V., Tomašič, T., Ilaš, J., Zidar, N., Peterlin Mašič, L., Barančoková, M., Frlan, R., Anderluh, M., Kikelj, D. & Tammela, P., 6 feb 2020, I : ChemBioChem : a European journal of chemical biology.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Anti-influenza virus activity of benzo[d]thiazoles that target heat shock protein 90

Lamut, A., Gjorgjieva, M., Naesens, L., Liekens, S., Lillsunde, K-E., Tammela, P., Kikelj, D. & Tomašič, T., 8 mar 2020, (!!Accepted/In press) I : Bioorganic Chemistry.

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Design, synthesis and biological evaluation of novel DNA gyrase Inhibitors and their siderophore mimic conjugates

Lamut, A., Cruz, C. D., Skok, Ž., Barančoková, M., Zidar, N., Zega, A., Peterlin Mašič, L., Ilaš, J., Tammela, P., Kikelj, D. & Tomašič, T., 2020, I : Bioorganic Chemistry. 95, 13 s., 103550.

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Inhibition of Nonessential Bacterial Targets: Discovery of a Novel Serine O-Acetyltransferase Inhibitor

Pinto de Magalhães, J., Franko, N., Raboni, S., Annunziato, G., Tammela, P., Bruno, A., Bettati, S., Mozzarelli, A., Pieroni, M., Cambanini, B. & Costantino, G., 13 feb 2020, I : ACS Medicinal Chemistry Letters.

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Second generation 4,5,6,7-tetrahydrobenzo[d]thiazoles as novel DNA gyrase inhibitors

Lamut, A., Skok, Ž., Barančoková, M., Gutierrez, L. J., Cruz, C., Tammela, P., Draskovits, G., Szili, P. É., Nyerges, Á., Pál, C., Molek, P., Bratkovič, T., Ilaš, J., Zidar, N., Zega, A., Enriz, R. D., Kikelj, D. & Tomašič, T., feb 2020, I : Future Medicinal Chemistry. 12, 4, s. 277-297 22 s.

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2019

An optimised series of substituted N-phenylpyrrolamides as DNA gyrase B inhibitors

Benetto Tiz, D., Skok, Ž., Durcik, M., Tomašič, T., Peterlin Mašič, L., Ilaš, J., Draskovits, G., Révész, T., Nyerges, Á., Pál, C., Cruz, C. D., Tammela, P. S. M., Žigon, D., Kikelj, D. & Zidar, N., 1 apr 2019, I : European Journal of Medicinal Chemistry. 167, s. 269-290 22 s.

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Antibacterial and antioxidative properties of different parts of garden rhubarb, blackcurrant, chokeberry and blue honeysuckle

Raudsepp, P., Koskar, J., Anton, D., Meremäe, K., Kapp, K., Laurson, P., Bleive, U., Kaldmäe, H., Roasto, M. & Püssa, T., 30 mar 2019, I : Journal of the Science of Food and Agriculture. 99, 5, s. 2311-2320 10 s.

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Antimicrobial Colloidal Silver-Lignin Particles via Ion- and Solvent Exchange

Sakari Lintinen, K., Luiro, S., Figueiredo, P., Sakarinen, E., Mousavi, Z., Seitsonen, J., N. S. Rivière, G., Mattinen, U., Niemelä, M., Tammela, P., Österberg, M., Johansson, L-S., Bobacka, J., Santos, H. A. & A. Kostiainen, M., 16 sep 2019, I : ACS Sustainable Chemistry & Engineering. 7, 18, s. 15297-15303 7 s.

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DPD-inspired discovery of novel LsrK kinase inhibitors: an opportunity to fight antimicrobial resistance

Stotani, S., Gatta, V., Medarametla, P., Padmanaban, M., Karawajzyk, A., Giordanetto, F., Tammela, P., Laitinen, T., Poso, A., Tzalis, D. & Collina, S., 14 mar 2019, I : Journal of Medicinal Chemistry. 62, 5, s. 2720-2737 18 s.

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Identification and characterization of approved drugs and drug-like compounds as covalent Escherichia coli ClpP inhibitors

Sassetti, E., Cruz, C. D., Tammela, P., Winterhalter, M., Augustyns, K., Gribbon, P. & Windshügel, B., 1 jun 2019, I : International Journal of Molecular Sciences. 20, 11, 13 s., 2686.

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Inhibition of Hepatitis C replication by targeting the molecular chaperone Hsp90 - synthesis and biological evaluation of 4,5,6,7-tetrahydrobenzo[1,2-d]thiazole derivatives

Lillsunde, K-E. M., Tomašič, T., Schult, P., Lohmann, V., Kikelj, D. & Tammela, P., 5 feb 2019, I : ChemMedChem : chemistry enabling drug discovery.. 14, 3, s. 334-342 9 s.

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New N-phenyl-4,5-dibromopyrrolamides as DNA gyrase B inhibitors

Zidar, N., Macut, H., Tomašič, T., Peterlin Mašič, L., Ilaš, J., Zega, A., Tammela, P. & Kikelj, D., 1 jun 2019, I : MedChemComm. 10, 6, s. 1007-1017 11 s.

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Targeting Quorum Sensing: High-Throughput Screening to Identify Novel LsrK Inhibitors

Gatta, V., Ilina, P., Porter, A., McElroy, S. & Tammela, P., 2 jun 2019, I : International Journal of Molecular Sciences. 20, 12, 17 s., 3112.

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α-Amino diphenyl phosphonates as novel inhibitors of Escherichia coli ClpP protease

Moreno-Cinos, C., Sassetti, E., Salado, I. G., Witt, G., Benramdane, S., Reinhardt, L., Cruz, C. D., Joossens, J., Van der Veken, P., Brötz-Oesterhelt, H., Tammela, P. S. M., Winterhalter, M., Gribbon, P., Windshügel, B. & Augustyns, K., 24 jan 2019, I : Journal of Medicinal Chemistry. 62, 2, s. 774-797 24 s.

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2018

A versatile strategy for the synthesis of 4,5-dihydroxy-2,3-pentadione (DPD) and related compounds as potential modulators of bacterial quorum sensing

Stotani, S., Gatta, V., Medda, F., Padmanaban, M., Karawajzyk, A., Tammela, P. S. M., Giordanetto, F., Tzalis, D. & Collina, S., 6 okt 2018, I : Molecules. 23, 10, 22 s., 2545.

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Defining conditions for biofilm inhibition and eradication assays for Gram-positive clinical reference strains

Cruz, C. D., Shah, S. & Tammela, P., 3 nov 2018, I : BMC Microbiology. 18, 9 s., 173.

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Design, Synthesis and Biological Evaluation of 1-Ethyl-3-(thiazol-2-yl)urea Derivatives as Escherichia coli DNA Gyrase Inhibitors

Tomašič, T., Barančoková, M., Zidar, N., Ilaš, J., Tammela, P. S. M. & Kikelj, D., 3 jan 2018, I : Archiv der Pharmazie : Chemistry in life sciences. 351, 1, 16 s., e1700333.

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Hyaluronic Acid Graft Copolymers with Cleavable Arms as Potential Intravitreal Drug Delivery Vehicles

Borke, T., Najberg, M., Ilina, P., Bhattacharya, M., Urtti, A., Tenhu, H. & Hietala, S., 1 jan 2018, I : Macromolecular Bioscience. 18, 1, 13 s., 1700200.

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Marine Microalgae: Promising Source for New Bioactive Compounds

de Vera, C. R., Díaz Crespín, G., Hernández Daranas, A., Montalvão Looga, S., Lillsunde, K-E., Tammela, P., Perälä, M., Hongisto, V., Virtanen, J., Rischer, H., Muller, C. D., Norte, M., Fernández, J. J. & Souto, M. L., 6 sep 2018, I : Marine Drugs. 16, 9, 12 s., 317.

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Miniaturized whole-cell bacterial bioreporter assay for identification of quorum sensing interfering compounds

Ilina, P., Ma, X., Sintim, H. O. & Tammela, P. S. M., nov 2018, I : Journal of Microbiological Methods. 154, s. 40-45 6 s.

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New N-phenylpyrrolamide DNA gyrase B inhibitors: Optimization of efficacy and antibacterial activity

Durcik, M., Lovison, D., Skok, Ž., Durante Cruz, C., Tammela, P., Tomašič, T., Benetto Tiz, D., Draskovits, G., Nyerges, Á., Pál, C., Ilaš, J., Peterlin Mašič, L., Kikelj, D. & Zidar, N., 25 jun 2018, I : European Journal of Medicinal Chemistry. 154, s. 117-132 16 s.

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Pumilol, a Diterpenoid with a Rare Strobane Skeleton from Pinus pumila (Pinaceae)

Langat, M., Helfenstein, A., Horner, C., Tammela, P., Hokkanen, H., Izotov, D. & Mulholland, D., 3 jul 2018, I : Chemistry & Biodiversity. 15, 10, 7 s., e1800056.

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Structure-based virtual screening of LsrK kinase inhibitors to target quorum sensing

Medarametla, P., Gatta, V., Kajander, T. A., Laitinen, T., Tammela, P. S. M. & Poso, A., 20 nov 2018, I : ChemMedChem : chemistry enabling drug discovery.. 13, 22, s. 2400-2407 8 s.

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Synthesis and Antiproliferative Activity of Marine Bromotyrosine Purpurealidin I and Its Derivatives

Bhat, C., Ilina, P., Tilli, I., Vorácova, M., Bruun, T., Barba, V., Hribernik, N., Lillsunde, K-E., Mäki-Lohiluoma, E., Rüffer, T., Lang, H., Yli-Kauhaluoma, J., Kiuru, P. & Tammela, P., 3 dec 2018, I : Marine Drugs. 16, 12, 26 s., 481.

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Synthesis and Evaluation of N-Phenylpyrrolamides as DNA Gyrase B Inhibitors

Durcik, M., Tammela, P. S. M., Barančoková, M., Tomašič, T., Ilaš, J., Kikelj, D. & Zidar, N., 22 jan 2018, I : ChemMedChem : chemistry enabling drug discovery.. 13, 2, s. 186-198 13 s.

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2017

Analyzing user-generated online content for drug discovery: Development and use of MedCrawler

Helfenstein, A. & Tammela, P., 15 apr 2017, I : Bioinformatics. 33, 8, s. 1205-1209 5 s.

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Antibacterial profiling of abietane-type diterpenoids

Helfenstein, A., Vahermo, M. M. A., Nawrot, D. A., Demirci, F., İşcan, G., Krogerus, S., Yli-Kauhaluoma, J. T., Moreira, V. M. & Tammela, P. S. M., jan 2017, I : Bioorganic & Medicinal Chemistry. 25, 1, s. 132-137 6 s.

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Design, synthesis and biological evaluation of 4,5-dibromo-N-(thiazol-2-yl)-1H-pyrrole-2-carboxamide derivatives as novel DNA gyrase inhibitors

Tomašič, T., Mirt, M., Barančoková, M., Ilaš, J., Zidar, N., Tammela, P. S. M. & Kikelj, D., 1 jan 2017, I : Bioorganic & Medicinal Chemistry. 25, 1, s. 338-349 12 s.

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Design, Synthesis and Evaluation of Novel Tyrosine-Based DNA Gyrase B Inhibitors

Cotman, A., Trampuž, M., Brvar, M., Kikelj, D., Ilaš, J., Peterlin-Mašič, L., Montalvao, S. I. G. H., Tammela, P. S. M. & Frlan, R., aug 2017, I : Archiv der Pharmazie : Chemistry in life sciences. 350, 8, 16 s., 1700087 .

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Discovery of substituted oxadiazoles as a novel scaffold for DNA gyrase inhibitors

Jakopin, Z., Ilas, J., Barancokova, M., Brvar, M., Tammela, P., Dolenc, M. S., Tomasic, T. & Kikelj, D., 21 apr 2017, I : European Journal of Medicinal Chemistry. 130, s. 171-184 14 s.

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Fabrication of concave micromirrors for single cell imaging via controlled over-exposure of organically modified ceramics in single step lithography

Bonabi, A., Cito, S., Tammela, P., Jokinen, V. & Sikanen, T., maj 2017, I : Biomicrofluidics. 11, 3, 11 s., 034118.

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Inhibition of Breast Cancer Resistance Protein and Multidrug Resistance Associated Protein 2 by Natural Compounds and Their Derivatives

Sjöstedt, N., Holvikari, K., Tammela, P. & Kidron, H., jan 2017, I : Molecular Pharmaceutics. 14, 1, s. 135-146 12 s.

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Marine alkaloid oroidin analogues with antiviral potential: a novel class of synthetic compounds targeting the cellular chaperone Hsp90

Lillsunde, K-E., Tomašič, T., Kikelj, D. & Tammela, P., dec 2017, I : Chemical Biology and Drug Design (Print). 90, 6, s. 1147-1154 8 s.

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Persistent Listeria monocytogenes strains isolated from mussel production facilities form more biofilm but are not linked to specific genetic markers

Nowak, J., Cruz, C. D., Tempelaars, M., Abee, T., van Vliet, A. H. M., Fletcher, G. C., Hedderley, D., Palmer, J. & Flint, S., 1 sep 2017, I : International Journal of Food Microbiology. 256, s. 45-53 9 s.

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Screening bioactivity and bioactive constituents of Nordic unifloral honeys

Salonen, A., Virjamo, V., Tammela, P. S. M., Fauch, L. & Julkunen-Tiitto, R., 18 maj 2017, I : Food Chemistry. 237, s. 214-224 11 s.

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2016

Cell-based bioreporter assay coupled to HPLC micro-fractionation in the evaluation of antimicrobial properties of the basidiomycete fungus Pycnoporus cinnabarinus

Järvinen, P. P., Nybond, S. C. S., Marcourt, L., Queiroz, E. F., Wolfender, J-L., Mettälä, A. H., Karp, M., Vuorela, H. J., Vuorela, P. M., Hatakka, A. I. & Tammela, P. S. M., 2016, I : Pharmaceutical Biology. 54, 6, s. 1108-1115 8 s.

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Discovery of bentzothiazole scaffold-based DNA gyrase B inhibitors

Gjorgjieva, M., Tomašič, T., Barančokova, M., Katsamakas, S., Ilaš, J., Tammela, P., Peterlin Mašič, L. & Kikelj, D., okt 2016, I : Journal of Medicinal Chemistry. 59, 19, s. 8941-8954 14 s.

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Large-scale bioprospecting of cyanobacteria, micro- and macroalgae from the Aegean Sea

Montalvao, S. I. G. H., Demirel, Z., Devi, P., Lombardi, V., Hongisto, V., Perälä, M., Hattara, J., Imamoglu, E., Shet Tilvi, S., Turan, G., Conk Dalay, M. & Tammela, P. S. M., 1 mar 2016, I : New Biotechnology. 33, 3, s. 399-406 8 s.

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Mint Flavorings from Candies Inhibit the Infectivity of Chlamydia pneumoniae

Hanski, L. L., Kapp, K., Tiirola, T. M., Orav, A., Vuorela, H. J., Püssa, T. & Vuorela, P. M., nov 2016, I : Natural Product Communications. 11, 11, s. 1725-1728 4 s.

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Minttujen (Mentha) koostumus ja antimikrobinen vaikutus

Kapp, K., 14 dec 2016, I : Dosis : farmaseuttinen aikakauskirja. 32, 2, s. 160-164 5 s.

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Nanofibrillar cellulose wound dressing in skin graft donor site treatment

Hakkarainen, T., Koivuniemi, R., Kosonen, M., Escobedo-Lucea, C., Sanz Garcia, A., Vuola, J., Valtonen, J., Tammela, P., Mäkitie, A., Luukko, K., Yliperttula, M. & Kavola, H., 2016, I : Journal of Controlled Release. 244, Part B, s. 292-301 10 s.

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New N-phenyl-4,5-dibromopyrrolamides and N-phenylindolamides as ATPase inhibitors of DNA gyrase

Zidar, N., Tomasic, T., Macut, H., Sirc, A., Brvar, M., Montalvao, S., Tammela, P., Ilas, J. & Kikelj, D., 30 mar 2016, I : European Journal of Medicinal Chemistry. 117, s. 197-211 15 s.

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Synthesis and biological evaluation of crown ether acyl derivatives

Febles, M., Montalvao, S. I. G. H., Crespín, G. D., Norte, M., Padrón, J. M., Tammela, P. S. M., Fernández, J. J. & Daranas, A. H., nov 2016, I : Bioorganic & Medicinal Chemistry Letters. 26, 22, s. 5591-5593 3 s.

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2015

Acetate-Derived Metabolites from the Brown Alga Lobophora variegata

Gutiérrez-Cepeda, A., Fernández, J. J., Norte, M., Montalvão, S., Tammela, P. & Souto, M. L., jul 2015, I : Journal of Natural Products. 78, 7, s. 1716-1722 7 s.

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Baltic cyanobacteria - a source of biologically active compounds

Mazur-Marzec, H., Błaszczyk, A., Felczykowska, A., Hohlfeld, N., Kobos, J., Toruńska-Sitarz, A., Devi, P., Montalvao, S., D'Souza, L., Tammela, P., Mikosik, A., Bloch, S., Nejman-Faleńczyk, B. & Węgrzyn, G., jul 2015, I : European Journal of Phycology. 50, 3, s. 343-360 18 s.

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Bioluminescent whole-cell reporter gene assays as screening tools in the identification of antimicrobial natural product extracts

Nybond, S. C. S., Karp, M., Yrjönen, T. J. & Tammela, P. S. M., maj 2015, I : Journal of Microbiological Methods. 114, s. 54-56 3 s.

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Discovery of 4,5,6,7-tetrahydrobenzo[1,2-d]thiazoles as novel DNA gyrase inhibitors targeting the ATP-binding site

Tomašič, T., Katsamakas, S., Hodnik, Ž., Ilaš, J., Brvar, M., Solmajer, T., Montalvao, S., Tammela, P., Banjanac, M., Ergović, G., Anderluh, M., Peterlin Mašič, L. & Kikelj, D., 23 jul 2015, I : Journal of Medicinal Chemistry. 58, 14, s. 5501-5521 21 s.

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Effect of differentiation on endocytic profiles of endothelial and epithelial cell culture models

Ilina, P., Partti, S., Niklander, J., Ruponen, M., Lou, Y-R. & Yliperttula, M., 1 mar 2015, I : Experimental Cell Research. 332, 1, s. 89-101 13 s.

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Exploring the structure-activity relationships of ABCC2 modulators using a screening approach

Wissel, G., Kudryavtsev, P., Ghemtio, L., Tammela, P., Wipf, P., Yliperttula, M., Finel, M., Urtti, A., Kidron, H. & Xhaard, H., 2015, I : Bioorganic & Medicinal Chemistry. 23, 13, s. 3513-3525 13 s.

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