Organisationsprofil

We assess the epidemiology, clinical impact and pathogenesis of human parvoviruses by development of an extensive repertoire of molecular and immunological diagnostic approaches and by characterization of virus-cell interactions.

Recent highlights:

- We showed that antibody EIA, mRNA RT-PCR or PCR of serum is needed for accurate diagnosis of acute HBoV1 infections, while the commonly used PCR of airway samples is insufficient.

- We showed that respiratory infections by HBoV1 are systemic, elicit immune responses, cause respiratory tract symptoms and otitis media, and affect almost all children before age 7.

- We showed that HBoV1 can persist in the upper airways for 6 months, cause life-threatening respiratory infections, can penetrate the blood-brain barrier causing encephalitis, and along with HBoV2-4, confuse serology by cross reactivity and an immunological phenomenon called “original antigenic sin”.

- We confirmed bufavirus to be a human virus and showed B-cell responses in humans.

- We found a striking difference in the global seroprevalence of BuV: 2-4% in Finland and the USA but 56-85% in Africa and the Middle East.

- We found a significant association of cutaneous T-cell lymphoma with detection of cutavirus DNA in skin biopsies.

Current team members: Elina Väisänen, Man Xu and Ushanandini Mohanraj

Recent short-term students: Yu Fu, Daranee Monthian, Maija Jokinen, and Michelle Ardales

Past PhD students: Kati Hokynar 2007, Laura Kakkola 2008, Anita Riipinen 2011, Päivi Norja 2012, Tingting Chen 2013, Kalle Kantola 2014, Reza Sadeghi 2014.

Internationellt och inhemskt samarbete Publikationer och projekt inom de senaste fem åren.

Personer

Ushanandini Mohanraj

Person: undervisnings- och forskningspersonal

Maria Söderlund-Venermo

maria.soderlund-venermo@helsinki.fi

Avdelningen för virologi - universitetslektor
Anja Maria Söderlund-Venermo / Ansvarig forskare

Person: HU, undervisnings- och forskningspersonal

Elina Väisänen

elina.vaisanen@helsinki.fi

Person: HU, Extern undervisning och koordinering av ämne

Man Xu

man.xu@helsinki.fi

Person: HU

Publikationer 2000 2019

118 Artikel
14 Översiktsartikel
7 Kapitel
4 Doktorsavhandling
4 Mer
- 2 Ledare
- 2 Brev

Cutavirus DNA in Malignant and Nonmalignant Skin of Cutaneous T-Cell Lymphoma and Organ Transplant Patients but Not of Healthy Adults

Väisänen, E., Fu, Y., Koskenmies, S., Fyhrquist, N., Wang, Y., Keinonen, A., Mäkisalo, H., Väkevä, L., Pitkänen, S., Ranki, A., Hedman, K. & Söderlund-Venermo, M., 1 jun 2019, I : Clinical Infectious Diseases. 68, 11, s. 1904-1910 7 s.

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

ICTV Virus Taxonomy Profile: Parvoviridae

ICTV Report Consortium, Cotmore, S. F., Agbandje-McKenna, M., Canuti, M., Soderlund-Venermo, M. & Tattersall, P., mar 2019, I : Journal of General Virology. 100, 3, s. 367-368 2 s., 001212.

Forskningsoutput: Tidskriftsbidrag › Ledare › Vetenskaplig

Öppen tillgång

Fil

Newly detected DNA viruses in juvenile nasopharyngeal angiofibroma (JNA) and oral and oropharyngeal squamous cell carcinoma (OSCC/OPSCC)

Dickinson, A., Xu, M., Silen, S., Wang, Y., Fu, Y., Sadeghi, M., Toppinen, M., Carpen, T., Hedman, K., Mäkitie, A. & Söderlund-Venermo, M., feb 2019, I : European Archives of Oto-Rhino-Laryngology. 276, 2, s. 613-617 5 s.

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

Öppen tillgång

Fil

Occurrence of newly discovered human polyomaviruses in skin of liver transplant recipients and their relation with squamous cell carcinoma in situ and actinic keratosis - a single-center cohort study

Wang, Y., Keinonen, A., Koskenmies, S., Pitkänen, S., Fyhrquist, N., Sadeghi, M., Mäkisalo, H., Söderlund-Venermo, M. & Hedman, K., maj 2019, I : Transplant International. 32, 5, s. 516-522 7 s.

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

Pulmonary function and bronchial reactivity 4 years after the first virus-induced wheezing

Leino, A., Lukkarinen, M., Turunen, R., Vuorinen, T., Söderlund-Venermo, M., Vahlberg, T., Camargo, C. A., Bochkov, Y. A., Gern, J. E. & Jartti, T., mar 2019, I : Allergy : European journal of allergy and clinical immunology. 74, 3, s. 518-526 9 s.

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review