Projekt per år
Organisationsprofil
Organisationsprofil
Public description:
We are now living in the second golden era of virology research. Newer techniques and detection methods are opening new frontiers in virus discovery. Since 2005, 9 novel human parvoviruses have been discovered, of which bocavirus 1 has been shown by us and others to cause mild to life-threatening pediatric respiratory tract infections, bufavirus to associate with diarrhea, and cutavirus with cutaneous T cell lymphoma. Many of these viruses have, however, been identified so recently that almost nothing is known of their biology, epidemiology or pathogenicity. We are determining the biological and clinical significance and spread of these emerging human parvoviruses by development of a complete repertoire of methods for their detection and accurate diagnosis of their infections. We further intend to characterize the viruses themselves and identify their cell- and tissue tropisms as well as the mechanism of persistence in our body. Novel unknown viruses like these can be of fundamental importance in causing acute or chronic illness, and assessment of their disease associations, epidemiology and molecular characteristics may provide new opportunities for the diagnosis, treatment and prevention of many diseases awaiting etiology. Our results have the potential to open new research avenues in basic and clinical virology, cancer research and health care.
Recent highlights:
- We showed that antibody EIA, mRNA RT-PCR or PCR of serum is needed for accurate diagnosis of acute HBoV1 infections, while the commonly used PCR of airway samples is insufficient.
- We showed that respiratory infections by HBoV1 are systemic, elicit immune responses, cause respiratory tract symptoms and otitis media, and affect almost all children before age 7.
- We showed that HBoV1 can persist in the upper airways for 6 months, cause life-threatening respiratory infections, can penetrate the blood-brain barrier causing encephalitis, and along with HBoV2-4, confuse serology by cross reactivity and an immunological phenomenon called “original antigenic sin”.
- We confirmed bufavirus to be a human virus and showed B-cell responses in humans.
- We found a striking difference in the global seroprevalence of BuV: 2-4% in Finland and the USA but 56-85% in Africa and the Middle East.
- We found a significant association of cutaneous T-cell lymphoma with detection of cutavirus DNA in skin biopsies.
- We found an even higher genoprevalence and significant association of CuV in parapsoriasis en plaques, a precursor of CTCL/MF.
Our team:
Current PhD students: Ushanandini Mohanraj, Rajita Rayamajhi Thapa, Sally Chesnut, Irini Assimakopoulou
Past PhD students: Kati Hokynar 2007, Laura Kakkola 2008, Anita Riipinen 2011, Päivi Norja 2012, Tingting Chen 2013, Kalle Kantola 2014, Reza Sadeghi 2014, Elina Väisänen 2020, Man Xu 2022.
Past graduate and short-term students: Anne Lahtinen, Inga Ziemle, Yu Fu, Daranee Monthian, Maija Jokinen, Michelle Ardales, Mari Toppinen, Tommaso Gritti.
Recent visiting senior researchers: Zaiga Nora-Krukle, Jingjing Li
PI: Maria Söderlund-Venermo
Vetenskapsgrenar
- 3111 Biomedicinska vetenskaper
Samarbeten och ledande forskningsområden under de senaste fem åren
Profiler
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Sally Chesnut
- Doctoral Programme in Biomedicine
- Anja Maria Söderlund-Venermo / Ansvarig forskare
- Medicum - Stipendieforskare
Person: gästforskare, Doktorand
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Rajita Rayamajhi Thapa
- Anja Maria Söderlund-Venermo / Ansvarig forskare
- Doctoral Programme in Population Health
- Avdelningen för virologi - doktorand
Person: U1 Undervisnings- och forskningspersonal, Doktorand
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Maria Söderlund-Venermo
- Anja Maria Söderlund-Venermo / Ansvarig forskare - gruppledare
- Avdelningen för virologi - universitetslektor
Person: U3 Undervisnings- och forskningspersonal, HU
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Cutavirus in inflammatory and neoplastic skin disorders
Salava, A. (Principal Investigator), Bugaeva, O. (deltagare), Väkevä, L. (deltagare) & Söderlund-Venermo, M. (Co-Principal Investigator)
01/01/2023 → …
Projekt: Forskningsprojekt
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Liv och Hälsa Söderlund-Venermo
Söderlund-Venermo, M. (Principal Investigator)
01/05/2023 → 30/04/2025
Projekt: Forskningsprojekt
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Human Parvoviruses: Epidemiology, Molecular Biology and Clinical Impact
Rayamajhi Thapa, R. (Projektledare)
08/07/2019 → 01/01/2025
Projekt: Forskningsprojekt
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The role of translational misregulation in tumorigenesis
Sarin, P. (Principal Investigator), Gregorova, P. (Deltagare) & Rayamajhi Thapa, R. (Deltagare)
01/05/2017 → 30/04/2020
Projekt: Forskningsprojekt
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Transfer RNA modifications as modulators of translation.
Sarin, P. (Principal Investigator), Koh, C. S. (Deltagare), Gregorova, P. (Deltagare), Hotti, H. (Deltagare), Rayamajhi Thapa, R. (Deltagare), Abendroth, U. (Deltagare) & Lampi, M. (Deltagare)
SUOMEN AKATEMIA, Academy of Finland
01/09/2016 → 31/08/2021
Projekt: Forskningsprojekt
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A customizable multiplex protein microarray for antibody testing and its application for tick-borne and other infectious diseases
Krishnamurthy, H. K., Jayaraman, V., Krishna, K., Wang, T., Bei, K., Changalath, C., Matilda, S., Rai, A. J., Welc-Falęciak, R., Pawełczyk, A., Blanton, L. S., Chrdle, A., Fořtová, A., Růžek, D., Nasrallah, G. K., Abu-Raddadi, L. J., Al-Sadeq, D. W., Abdallah, M. A. A., Lilleri, D. & Fornara, C. & 10 andra, , 20 jan. 2025, I: Scientific Reports. 15, 1, 12 s., 2527.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
Öppen tillgångFil -
A Diagnostic Approach to Separate Acute Human Bocavirus 1 Respiratory Tract Infection From Long-lasting Virus Shedding
Thapa, R. R., Nascimento-Carvalho, C., Allander, T., Jartti, T. & Söderlund-Venermo, M., 15 maj 2025, I: Journal of Infectious Diseases. 231, 5, s. e862-e866 5 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
Öppen tillgångFil -
Expression of toll-like receptors in recurrent pleomorphic adenoma and carcinoma ex pleomorphic adenoma
Jauhiainen, M. K., Markkanen, A., Atula, T., Aro, K., Haglund, C., Söderlund-Venermo, M., Mäkitie, A. A., Sinkkonen, S. T. & Hagström, J., jan. 2025, I: APMIS. 133, 1, 8 s., APM13505.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
Öppen tillgångFil -
In search of human protoparvovirus acute infections
Chesnut, S. K., Mohanraj, U., Thapa, R. R., Jalilian, F. A., Amini, R., Sedighi, I., Sedighi, P., Al-Hello, H., Barakat, A. M., Masika, M., Mwaengo, D., Anzala, O., Nora-Krukle, Z., Vilmane, A., Ziemele, I., Manaresi, E., Gallinella, G., Viikari, L., Jartti, T. & Söderlund-Venermo, M., juli 2025, I: Virology. 608, 9 s., 110529.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
Öppen tillgångFil -
Multiple DNA Viruses and HPV Integration in Inverted Papilloma and Associated Sinonasal Carcinoma
Jauhiainen, M. K., Pyöriä, L., Viitasalo, S., Mohanraj, U., Aaltonen, L.-M., Söderlund-Venermo, M., Hagström, J., Mäkitie, A. A., Perdomo, M. F. & Sinkkonen, S. T., feb. 2025, I: Laryngoscope. 135, 2, s. 677-686 10 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
Öppen tillgångFil
Aktiviteter
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XIX Parvovirus Workshop
Söderlund-Venermo, M. (Medlem av vetenskaplig kommitté)
3 sep. 2024 → 7 sep. 2024Aktivitet: Typer för deltagande i eller organisering av evenemang › Arrangemang av och deltagande i konferens/workshop/kurs/seminarium
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Viruses (Basel) (Tidskrift)
Söderlund-Venermo, M. (Referentgranskare)
2024Aktivitet: Typer för peer review av output och redaktionsarbete › Referentgranskning av manuskript
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Cells (Tidskrift)
Söderlund-Venermo, M. (Referentgranskare)
2024Aktivitet: Typer för peer review av output och redaktionsarbete › Referentgranskning av manuskript
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XIX Parvovirus Workshop
Söderlund-Venermo, M. (Talare: Inledningsanförande (keynote))
4 sep. 2024Aktivitet: Typer för deltagande i eller organisering av evenemang › Arrangemang av och deltagande i konferens/workshop/kurs/seminarium
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Prevalence and activity of cutavirus in cutaneous T-cell lymphoma and parapsoriasis en plaques
Mohanraj, U. (!!Speaker)
17 apr. 2024Aktivitet: Typer för tal eller presentation › !!Oral presentation
Priser
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Award for outstanding review
Söderlund-Venermo, M. (!!Recipient), 2008
Pris: Pris och hedersbetygelser
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Award for outstanding review
Söderlund-Venermo, M. (!!Recipient), 2010
Pris: Pris och hedersbetygelser
Tidningsurklipp
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Interview in Keskisuomalainen magazine about viruses
28/03/2021
1 Mediabidrag
Press/media: !!Press / Media
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Prisma Studio TV science program: Tutkijat hyökkäävät vaarallisten uusien virusten kimppuun
09/01/2008
1 Mediabidrag
Press/media: !!Press / Media
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Interview in the Yliopisto magazine: ssDNA viruses in our tissues
01/10/2007
1 Mediabidrag
Press/media: !!Press / Media