Publikationer

2020

Design and application of oncolytic viruses for cancer immunotherapy

Ylösmäki, E. & Cerullo, V., okt 2020, I : Current Opinion in Biotechnology. 65, s. 25-36 12 s.

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Exploiting Preexisting Immunity to Enhance Oncolytic Cancer Immunotherapy

Tähtinen, S., Feola, S., Capasso, C., Laustio, N., Groeneveldt, C., Ylösmäki, E. O., Ylösmäki, L., Martins, B., Fusciello, M., Medeot, M., Tagliamonte, M., Chiaro, J., Hamdan, F., Peltonen, K., Ranki, T., Buonaguro, L. & Cerullo, V., 15 jun 2020, I : Cancer Research. 80, 12, s. 2575-2585 11 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Extracellular vesicles provide a capsid-free vector for oncolytic adenoviral DNA delivery

Saari, H., Turunen, T., Lohmus, A., Turunen, M., Jalasvuori, M., Butcher, S. J., Yla-Herttuala, S., Viitala, T., Cerullo, V., Siljander, P. R. M. & Yliperttula, M., 1 jan 2020, I : Journal of Extracellular Vesicles. 9, 1, 24 s., 1747206.

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Front cover - Cell Membrane Wrapping: Influence of Cell Membrane Wrapping on the Cell−Porous Silicon Nanoparticle Interactions (Adv. Healthcare Mater. 17/2020)

Fontana, F., Lindstedt, H., Correia, A., Chiaro, J., Kari, O., Ndika, J., Alenius, H., Buck, J., Sieber, S., Mäkilä, E., Salonen, J., Urtti, A., Cerullo, V., Hirvonen, J. & Santos, H. A., 9 sep 2020, I : Advanced Healthcare Materials. 9, 17, 9 s., 2070056.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Influence of Cell Membrane Wrapping on the Cell-Porous Silicon Nanoparticle Interactions

Fontana, F., Lindstedt, H., Correia, A., Chiaro, J., Kari, O., Ndika, J., Alenius, H., Buck, J., Sieber, S., Mäkilä, E., Salonen, J., Urtti, A., Cerullo, V., Hirvonen, J. & Santos, H. A., 9 sep 2020, I : Advanced Healthcare Materials. 9, 17, 9 s., 2000529.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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MicroRNA-193a family as potential clinical biomarker and therapeutic agent in advanced Melanoma

Carpi, S., Polini, B., Ylösmäki, L., Ylösmäki, E., Cerullo, V., Romanini, A. & Nieri, P., 11 feb 2020, I : Journal of Translational Medicine. 18, Supplement 1, 1 s., 25.

Forskningsoutput: TidskriftsbidragMötesabstraktForskningPeer review

Novel chimerized IgA CD20 antibodies: Improving neutrophil activation against CD20-positive malignancies

Evers, M., Ten Broeke, T., Jansen, J. H. M., Nederend, M., Hamdan, F., Reiding, K. R., Meyer, S., Moerer, P., Brinkman, I., Rösner, T., Lebbink, R. J., Valerius, T. & Leusen, J. H. W., 1 jan 2020, I : MAbs. 12, 1, 10 s., 1795505.

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Tumor Suppressor Role of hsa-miR-193a-3p and-5p in Cutaneous Melanoma

Polini, B., Carpi, S., Doccini, S., Citi, V., Martelli, A., Feola, S., Santorelli, F. M., Cerullo, V., Romanini, A. & Nieri, P., sep 2020, I : International Journal of Molecular Sciences. 21, 17, 18 s., 6183.

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Uncovering the Tumor Antigen Landscape: What to Know about the Discovery Process

Feola, S., Chiaro, J., Martins, B. & Cerullo, V., jun 2020, I : Cancers. 12, 6, 28 s., 1660.

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2019
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Biohybrid Cloaked Nanovaccines for Cancer Immunotherapy

Fontana, F., 14 jun 2019, Helsinki: Helsinki University Printing House. 78 s.

Forskningsoutput: AvhandlingDoktorsavhandlingSamling av artiklar

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Biohybrid Vaccines for Improved Treatment of Aggressive Melanoma with Checkpoint Inhibitor

Fontana, F., Fusciello, M., Groeneveldt, C., Capasso, C., Chiaro, J., Feola, S., Liu, Z., Mäkilä, E., Salonen, J., Hirvonen, J., Cerullo, V. & Santos, H. A., jun 2019, I : ACS Nano. 13, 6, s. 6477-6490 14 s.

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Extracellular vesicles enhance the targeted delivery of immunogenic oncolytic adenovirus and paclitaxel in immunocompetent mice

Garofalo, M., Villa, A., Rizzi, N., Kuryk, L., Rinner, B., Cerullo, V., Yliperttula, M., Mazzaferro, V. & Ciana, P., 28 jan 2019, I : Journal of Controlled Release. 294, s. 165-175 11 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1/2-dependent apoptosis

Turunen, S. P., von Nandelstadh, P., Öhman, T., Gucciardo, E., Seashore-Ludlow, B., Martins, B., Rantanen, V., Li, H., Höpfner, K., Östling, P., Varjosalo, M. & Lehti, K., dec 2019, I : Cell Death and Differentiation. 26, 12, s. 2577-2593 17 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Harnessing therapeutic viruses as a delivery vehicle for RNA-based therapy

Ylösmäki, L., Polini, B., Carpi, S., Martins, B., Smertina, E., Feola, S., Fusciello, M., Peltonen, K., Nieri, P., Ylösmäki, E. & Cerullo, V., 23 okt 2019, I : PLoS One. 14, 10, s. e0224072

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Helper-dependent adenovirus-mediated gene transfer of a secreted LDL receptor/transferrin chimeric protein reduces aortic atherosclerosis in LDL receptor-deficient mice

Leggiero, E., Labruna, G., Iaffaldano, L., Lombardo, B., Greco, A., Fiorenza, D., Gramanzini, M., Montanaro, D., Baldi, A., Cerullo, V., Sacchetti, L. & Pastore, L., apr 2019, I : Gene Therapy (Basingstoke). 26, 3-4, s. 121-130 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Oncolytic adenovirus drives specific immune response generated by a poly-epitope pDNA vaccine encoding melanoma neoantigens into the tumor site

Lopes, A., Feola, S., Ligot, S., Fusciello, M., Vandermeulen, G., Préat, V. & Cerullo, V., 10 jul 2019, I : Journal for Immunotherapy of Cancer. 7, 1, 14 s., 174.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Optimization of Early Steps in Oncolytic Adenovirus ONCOS-401 Production in T-175 and HYPERFlasks

Kuryk, L., Moller, A-S. W., Vuolanto, A., Pesonen, S., Garofalo, M., Cerullo, V. & Jaderberg, M., 1 feb 2019, I : International Journal of Molecular Sciences. 20, 3, 15 s., 621.

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Peptide Nucleic Acid-Functionalized Adenoviral Vectors Targeting G-Quadruplexes in the P1 Promoter of Bcl-2 Proto-Oncogene: A New Tool for Gene Modulation in Anticancer Therapy

Falanga, A. P., Cerullo, V., Marzano, M., Feola, S., Oliviero, G., Piccialli, G. & Borbone, N., mar 2019, I : Bioconjugate Chemistry. 30, 3, s. 572-582 11 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Synergistic effect of combined administration of an oncolytic adenovirus and Bifidobacterium spp. supplements in a mouse model of melanoma

Tripodi, L., Leggiero, E., D'Argenio, V., Granata, I., Capasso, C., Passariello, M., D'Agostino, A., Guarracino, M. R., De Lorenzo, C., Cerullo, V. & Pastore, L., 1 nov 2019, I : Human Gene Therapy. 30, 11, s. A30-A31 2 s.

Forskningsoutput: TidskriftsbidragMötesabstraktForskningPeer review

2018

Antitumor effect of oncolytic virus and paclitaxel encapsulated in extracellular vesicles for lung cancer treatment

Garofalo, M., Saari, H., Somersalo, P., Crescenti, D., Kuryk, L., Aksela, L., Capasso, C., Madetoja, M., Koskinen, K., Oksanen, T., Mäkitie, A., Jalasvuori, M., Cerullo, V., Ciana, P. & Yliperttula, M., 10 aug 2018, I : Journal of Controlled Release. 283, s. 223-234 12 s.

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Antitumor-specific T-cell responses induced by oncolytic adenovirus ONCOS-102 (AdV5/3-D24-GM-CSF) in peritoneal mesothelioma mouse model

Kuryk, L., Moller, A-S. W., Garofalo, M., Cerullo, V., Pesonen, S., Alemany, R. & Jaderberg, M., okt 2018, I : Journal of Medical Virology. 90, 10, s. 1669-1673 5 s.

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Cancer-Targeted Oncolytic Adenoviruses for Modulation of the Immune System

Cerullo, V., Capasso, C., Vähä-Koskela, M., Hemminki, O. & Hemminki, A., 2018, I : Current Cancer Drug Targets. 18, 2, s. 124-138 15 s.

Forskningsoutput: TidskriftsbidragÖversiktsartikelVetenskapligPeer review

Development of Biohybrid Multistage Nanovaccines for Melanoma

Fontana, F., Capasso, C., Shahbazi, M-A., Liu, D., Fusciello, M., Feola, S., Zhang, H., Mäkilä, E., Salonen, J., Hirvonen, J. T., Cerullo, V. & Almeida Santos, H., 2018.

Forskningsoutput: KonferensbidragSammanfattning

Oncolytic Adenoviruses Encapsulated into the Extracellular Vesicles as Carriers for Cancer Drug Delivery

Garofalo, M., Saari, H., Somersalo, P., Crescenti, D., Kuryk, L., Aksela, L., Capasso, C., Madetoja, M., Koskinen, K., Makitie, A., Jalasvuori, M., Cerullo, V., Ciana, P. & Yliperttula, M., maj 2018, I : Molecular therapy. 26, 5, s. 203-203 1 s.

Forskningsoutput: TidskriftsbidragMötesabstraktForskningPeer review

Oncolytic vaccines increase the response to PD-L1 blockade in immunogenic and poorly immunogenic tumors

Feola, S., Capasso, C., Fusciello, M., Martins, B., Tähtinen, S., Medeot, M., Carpi, S., Frascaro, F., Ylösmaki, E., Peltonen, K., Pastore, L. & Cerullo, V., 2018, I : OncoImmunology. 7, 8, 10 s., 1457596.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Personalized Cancer Vaccine Platform for Clinically Relevant Oncolytic Enveloped Viruses

Ylösmäki, E., Malorzo, C., Capasso, C., Honkasalo, O., Fusciello, M., Martins, B., Ylösmäki, L., Louna, A., Feola, S., Paavilainen, H., Peltonen, K., Hukkanen, V., Viitala, T. & Cerullo, V., 5 sep 2018, I : Molecular therapy. 26, 9, s. 2315-2325 11 s.

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Small-Molecule Targeting of RNA Polymerase I Activates a Conserved Transcription Elongation Checkpoint

Wei, T., Najmi, S. M., Liu, H., Peltonen, K., Kucerova, A., Schneider, D. A. & Laiho, M., 10 apr 2018, I : Cell Reports. 23, 2, s. 404-414 11 s.

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The microenvironment of proliferative diabetic retinopathy supports lymphatic neovascularization

Gucciardo, E., Loukovaara, S., Korhonen, A., Repo, P., Martins, B., Vihinen, H., Jokitalo, E. & Lehti, K., jun 2018, I : Journal of Pathology. 245, 2, s. 172-185 14 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2017

ANKRD54 preferentially selects Bruton's Tyrosine Kinase (BTK) from a Human Src-Homology 3 (SH3) domain library

Gustafsson, M. O., Mohammad, D. K., Ylosmaki, E., Choi, H., Shrestha, S., Wang, Q., Nore, B. F., Saksela, K. & Smith, C. I. E., 3 apr 2017, I : PLoS One. 12, 4, 13 s., 0174909.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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A novel in silico framework to improve MHC-I epitopes and break the tolerance to melanoma

Capasso, C., Magarkar, A., Cervera-Carascon, V., Fusciello, M., Feolaf, S., Muller, M., Garofalo, M., Kuryk, L., Tahtinen, S., Pastore, L., Bunker, A. & Cerullo, V., 2017, I : OncoImmunology. 6, 9, 14 s., 1319028.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Homology between cancer and viral epitopes as criteria to design improved cancer vaccines

Capasso, C., Whalley, T., Marwah, V. S., Serafin, A., Fusciello, M., Feola, S., Martins, B., Greco, D., Szomolay, B. & Cerullo, V., dec 2017, I : Annals of Oncology. 28, 1 s., 63P.

Forskningsoutput: TidskriftsbidragMötesabstraktForskningPeer review

Metastatic state of parent cells influences the uptake and functionality of prostate cancer cell-derived extracellular vesicles

Lazaro Ibañez, E., Neuvonen, K. M., Takatalo-Laine, S. M., Thanigai Arasu, U., Capasso, C., Cerullo, V., Rhim, J., Rilla, K., Yliperttula, M. L. & Siljander, P. R-M., 10 aug 2017, I : Journal of Extracellular Vesicles.

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Severe neurodegenerative disease in brothers with homozygous mutation in POLR1A

Kara, B., Koroglu, C., Peltonen, K., Steinberg, R. C., Genc, H. M., Holtta-Vuori, M., Guven, A., Kanerva, K., Kotil, T., Solakoglu, S., Zhou, Y., Olkkonen, V. M., Ikonen, E., Laiho, M. & Tolun, A., feb 2017, I : European Journal of Human Genetics. 25, 3, s. 315-323 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Thiol-ene surface modifications for microchip electrophoresis based interaction assays

Tähkä, S., Batelic, L., Capasso, C., Wiedmer, S. K., Cerullo, V. & Sikanen, T. M., okt 2017, s. 1535-1536. 2 s.

Forskningsoutput: KonferensbidragSammanfattning

Toxicological and bio-distribution profile of a GM-CSF-expressing, double-targeted, chimeric oncolytic adenovirus ONCOS-102-Support for clinical studies on advanced cancer treatment

Kuryk, L., Vassilev, L., Ranki, T., Hemminki, A., Karioja-Kallio, A., Levälampi, O., Vuolanto, A., Cerullo, V. & Pesonen, S., 10 aug 2017, I : PLoS One. 12, 8, 15 s., 0182715.

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Uptake and functionality of prostate cancer extracellular vesicles depends on the metastatic stage of the parent cells

Lazaro Ibanez, E., Neuvonen, K. M., Takatalo-Laine, S. M., Thanigai Arasu, U., Capasso, C., Rhim, J., Rilla, K., Yliperttula, M. L. & Siljander, P. R-M., maj 2017, I : Journal of Extracellular Vesicles. 6, sup1

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2016

Chronic Activation of Innate Immunity Correlates With Poor Prognosis in Cancer Patients Treated With Oncolytic Adenovirus

Taipale, K., Liikanen, I., Juhila, J., Turkki, R., Tahtinen, S., Kankainen, M., Vassilev, L., Ristimaki, A., Koski, A., Kanerva, A., Diaconu, I., Cerullo, V., Vaha-Koskela, M., Oksanen, M., Linder, N., Joensuu, T., Lundin, J. & Hemminki, A., jan 2016, I : Molecular therapy. 24, 1, s. 175-183 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Expression of DAI by an oncolytic vaccinia virus boosts the immunogenicity of the virus and enhances antitumor immunity

Hirvinen, M., Capasso, C., Guse, K., Garofalo, M., Vitale, A., Ahonen, M., Kuryk, L., Vähä-Koskela, M., Hemminki, A., Fortino, V., Greco, D. & Cerullo, V., 23 mar 2016, I : Molecular Therapy - Oncolytics. 3, 9 s., 16002.

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Oncogenic Herpesvirus Utilizes Stress-Induced Cell Cycle Checkpoints for Efficient Lytic Replication

Balistreri, G., Viiliainen, J., Turunen, M., Diaz, R., Lyly, L., Pekkonen, P., Rantala, J., Ojala, K., Sarek, G., Teesalu, M., Denisova, O., Peltonen, K., Julkunen, I., Varjosalo, M., Kainov, D., Kallioniemi, O., Laiho, M., Taipale, J., Hautaniemi, S. & Ojala, P. M., feb 2016, I : PLoS Pathogens. 12, 2, 26 s., 1005424.

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Oncolytic adenoviruses coated with MHC-I tumor epitopes increase the anti-tumor immunity and efficacy against melanoma

Capasso, C., Hirvinen, M., Garofalo, M., Romaniuk, D., Kuryk, L., Sarvela, T., Vitale, A., Antopolsky, M., Magarkar, A., Viitala, T., Suutari, T., Bunker, A., Yliperttula, M., Urtti, A. & Cerullo, V., 2016, I : OncoImmunology. 5, 4, 11 s., 1105429.

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Oncolytic Adenovirus Loaded with L-carnosine as Novel Strategy to Enhance the Antitumor Activity

Garofalo, M., Iovine, B., Kuryk, L., Capasso, C., Hirvinen, M., Vitale, A., Yliperttula, M., Bevilacqua, M. A. & Cerullo, V., apr 2016, I : Molecular Cancer Therapeutics. 15, 4, s. 651-660 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Selective replication of miR-145-regulated oncolytic adenovirus in MCF-7 breast cancer cells

Shayestehpour, M., Moghim, S., Salimi, V., Jalilvand, S., Yavarian, J., Romani, B., Ylosmaki, E. & Mokhtari-Azad, T., okt 2016, I : Future Virology. 11, 10, s. 671-680 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Synergistic anti-tumor efficacy of immunogenic adenovirus ONCOS-102 (Ad5/3-D24-GM-CSF) and standard of care chemotherapy in preclinical mesothelioma model

Kuryk, L., Haavisto, E., Garofalo, M., Capasso, C., Hirvinen, M., Pesonen, S., Ranki, T., Vassilev, L. & Cerullo, V., 15 okt 2016, I : International Journal of Cancer. 139, 8, s. 1883-1893 11 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Treatment of osteoarthritis using a helper-dependent adenoviral vector retargeted to chondrocytes

Ruan, M. Z. C., Cerullo, V., Cela, R., Clarke, C., Lundgren-Akerlund, E., Barry, M. A. & Lee, B. H. L., 2016, I : Molecular therapy-Methods & clinical development. 3, 8 s., 16008.

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2015

GMCSF-armed vaccinia virus induces an antitumor immune response

Parviainen, S., Ahonen, M., Diaconu, I., Kipar, A., Siurala, M., Vaha-Koskela, M., Kanerva, A., Cerullo, V. & Hemminki, A., 1 mar 2015, I : International Journal of Cancer. 136, 5, s. 1065-1072 8 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Immunological Effects of a Tumor Necrosis Factor Alpha-Armed Oncolytic Adenovirus

Hirvinen, M., Rajecki, M., Kapanen, M., Parviainen, S., Rouvinen-Lagerstrom, N., Diaconu, I., Nokisalmi, P., Tenhunen, M., Hemminki, A. & Cerullo, V., 1 mar 2015, I : Human Gene Therapy. 26, 3, s. 134-144 11 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

New oncolytic vaccine platform enhance anti-tumor immunity in humanized mice with human melanomas

Capasso, C., Hirvinen, M., Garofalo, M., Romaniuk, D., Kuryk, L., Sarvela, T., Vitale, A., Antopolsky, M., Magarkar, A., Viitala, T., Suutari, T., Bunker, A., Yliperttula, M., Urtti, A. & Cerullo, V., 1 okt 2015, I : Human Gene Therapy. 26, 10, s. A53-A53 1 s.

Forskningsoutput: TidskriftsbidragMötesabstraktForskningPeer review