Projekt per år
Organisationsprofil
Organisationsprofil
Varjosalo Lab
Our longstanding interest is the global and comprehensive understanding of how key cellular signaling molecules; protein kinases, protein phosphatases and transcription factors mediate their signaling potential and how the signaling is changed in diseases in the immuno-oncology axis. For this purpose, we have developed experimental and computational methods to identify the protein-interactions formed by these signaling molecules. Additionally, we employ quantitative mass spectrometry -based proteomics on assessing the protein abundance changes, as well as phosphorylation status of the tissues/cells. Furthermore, combining the data from the different sets of ‘omics’ data (proteomics, HTS and HiSeq), allows us to generate global and systems level understanding on how disease-causing mutations mediate their effects, enabling also the development of therapeutic or diagnostic approaches. Read more on our website.
Internationellt och inhemskt samarbete
Publikationer och projekt inom de senaste fem åren.
Personer
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Salla Keskitalo
- Institutet för bioteknik - laboratoriechef
- Molecular Systems Biology
Person: M5 Stödspersonal for undervisning och forskning
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Matias Kinnunen
- Institutet för bioteknik - Stipendieforskare
- Molecular Systems Biology
Person: gästforskare
Utrustning
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Instruct-ERIC Structural Biology European Research Infrastructure Centre Finland
Butcher, S. (Chef), Oksanen, H. M. (Annat), Poranen, M. (Annat), Eskelin , K. (Annat), Permi, P. (Annat), Varjosalo, M. (Annat), Lehtiö, L. (Annat) & Rouvinen, J. (Annat)
Bio- och miljövetenskapliga fakultetenUtrustning/facilitet: Coordination office
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Integrated Structural Biology Infrastructure-European Research Infrastructure Consortium (Instruct-ERIC) / Consortium FINStruct and Instruct-ERIC
Butcher, S. (Principal Investigator), Poranen, M. (Co-Principal Investigator), Varjosalo, M. (Principal Investigator), Kajander, T. (Co-Principal Investigator), Oksanen, H. M. (Deltagare), Eskelin , K. (Deltagare), Lehtiö, L. (Principal Investigator), Salminen, T. A. (Deltagare) & Papageorgiou, A. C. (Deltagare)
01/01/2022 → 31/12/2026
Projekt: Finlands Akademi: Forskningsinfrastruktur
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Generation Green
Sikanen, T. (Deltagare), Yli-Kauhaluoma, J. (Deltagare), Hirvonen, J. (Deltagare), Vuorela, P. (Deltagare), Kärkkäinen, R. (Deltagare), Vuorensola, K. (Deltagare), Teppo, J. (Deltagare), Salminen, O. (Deltagare), Sivula, S. (Deltagare) & Teräsalmi, E. (Deltagare)
01/01/2015 → …
Projekt: Annan projekt
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Structural Biology Finland (FINStruct) & Instruct-ERIC Centre FI / Research Infrastructure Roadmap 2021-2024
Butcher, S. (Principal Investigator), Poranen, M. (Co-Principal Investigator), Kajander, T. (Co-Principal Investigator), Iwai, H. (Co-Principal Investigator), Varjosalo, M. (Co-Principal Investigator), Lehtiö, L. (Co-Principal Investigator), Rouvinen, J. (Co-Principal Investigator), Salminen, T. A. (Co-Principal Investigator), Papageorgiou, A. C. (Co-Principal Investigator), Oksanen, H. M. (Deltagare) & Eskelin , K. (Deltagare)
01/01/2021 → 31/12/2024
Projekt: Finlands Akademi: Forskningsinfrastruktur
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Genome, transcriptome and proteome of the wood-decay fungus Phlebia radiata
Lundell, T. (Projektledare), Kuuskeri, J. (Deltagare), Mäkinen, M. (Deltagare), Paulin, L. (Deltagare), Laine, P. (Deltagare), Smolander, O.-P. (Deltagare), Varjosalo, M. (Deltagare) & Auvinen, P. (Deltagare)
03/01/2011 → 31/12/2017
Projekt: Forskningsprojekt
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Insight into the function of the Golgi membrane protein GOLM1 in cholangiocytes through interactomic analysis
Nagaraj, M., Emmagouni, S. K. G., Chaurasiya, V., Li, L., Nguyen, V. D., Keskitalo, S., Varjosalo, M., Zhou, Y., Haridas, P. A. N. & Olkkonen, V. M., feb. 2025, (!!E-pub ahead of print) I: FEBS Letters. 18 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Nuclear Factor I Family Members are Key Transcription Factors Regulating Gene Expression
Malaymar Pinar, D., Göös, H., Tan, Z., Kumpula, E.-P., Chowdhury, I., Wang, Z., Zhang, Q., Salokas, K., Keskitalo, S., Wei, G. H., Kumbasar, A. & Varjosalo, M., jan. 2025, I: Molecular and Cellular Proteomics. 24, 1, 21 s., 100890.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
Öppen tillgång -
Pulmonary Aspergillosis and Low HIES Score in a Family with STAT3 N-Terminal Domain Mutation
Lima de Souza, S., Asano, T., Glumoff, V., Keskitalo, S., Pikkarainen, K., Martelius, T., Kaustio, M., Saarela, J., Kuismin, O., Lappi-Blanco, E., Jartti, A., Yannopoulos, F., Tiitto, L., Seppänen, M. R. J., Boisson, B., Casanova, J. L., Varjosalo, M., Hautala, T. & Chen, Z., 2025, I: Journal of clinical immunology. 45, 1, 11 s., 73.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
Öppen tillgångFil -
SUMOylation inhibition potentiates the glucocorticoid receptor to program growth arrest of acute lymphoblastic leukemia cells
Valima, E., Varis, V., Bureiko, K., Lempiäinen, J. K., Schroderus, A.-M., Oksa, L., Lohi, O., Kinnunen, T., Varjosalo, M. T., Niskanen, E. A., Paakinaho, V. & Palvimo, J. J., 14 feb. 2025, (!!E-pub ahead of print) I: Oncogene. 13 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
Öppen tillgång -
The role of Nir2, a lipid-transfer protein, in regulating endothelial cell functions
Polianskyte-Prause, Z., Arora, A., Taskinen, J. H., Chaurasiya, V., Keskitalo, S., Tuhkala, A., Hilska, I., Varjosalo, M. & Olkkonen, V. M., mars 2025, I: Biochimica et Biophysica Acta. Molecular Cell Research. 1872, 3, 15 s., 119926.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
Aktiviteter
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iCAN retreat 2024
Kremneva, E. (Ordförande i organisationskommitté), Kolikova, Y. (Medlem i organisationskommitté), Laakkonen, P. (Medlem i organisationskommitté), Vanharanta, S. (Medlem i organisationskommitté), Varjosalo, M. (Medlem i organisationskommitté), Wahl, H. (Medlem i organisationskommitté), Sankkila-Forsström, S. S. (Medlem i organisationskommitté), Duàn, H. (Talare: Presentation), Karhemo, P.-R. (Talare: Presentation), Miihkinen, M. S. (Talare: Presentation), Liljeström, M. (Medlem i organisationskommitté), Pietiäinen, V. (Talare: Presentation), Ganesan, A. (Poster presentation), Saad, J. (Poster presentation), Holmström, S. (Poster presentation), Brodkin, J. H. (Poster presentation), Mendoza Ortiz, E. D. (Poster presentation), Sundaresan, S. (Poster presentation), Chiaro, J. (Poster presentation), Giannoula, Y. (Poster presentation), Portaankorva, A. M. (Talare: Presentation), Mustjoki, S. (Talare: Presentation), Mäkelä, T. (Talare: Presentation), Atarsaikhan, G. (Poster presentation), Filppu, P. (Poster presentation), Russo, S. (Poster presentation), Pikkusaari, S. K. (Poster presentation), Ryzhenkov, A. (Poster presentation), Newman, R. G. D. (Talare: Presentation), Arffman, M. E. (Talare: Presentation), Kumari, R. (Poster presentation), Leppiniemi, S. A. (Poster presentation), Sanjaya, P. (Poster presentation), Feodoroff, M. J. (Poster presentation), Karabayev, D. (Poster presentation), Jäntti, J. M. (Poster presentation), Wong Ramirez, J. R. C. (Poster presentation), Kalander, K. O. (Poster presentation), Bouhlal, J. O. V. (Talare: Presentation), Kuusela, S. (Talare: Presentation), Fey, E. (Talare: Presentation), Krami Senhaji, O. (Poster presentation), Moradi, N. (Poster presentation), Polso, M. M. M. (Poster presentation), Antignani, G. (Poster presentation), Maljanen, K. J. (Poster presentation), Langohr, L. (Poster presentation), Anil, A. (Poster presentation), Smolander, P. J. (Poster presentation), Feodoroff, M. J. (Poster presentation), Alsaed, B. (Poster presentation), Mogollon Figueroa, I. (Poster presentation), Ryzhenkov, A. (Poster presentation) & Henriksson, M. E. J. (Poster presentation)
3 okt. 2024Aktivitet: Typer för deltagande i eller organisering av evenemang › Arrangemang av och deltagande i konferens/workshop/kurs/seminarium
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Serum proteomics to detect early changes in type 1 diabetes and carotid atherosclerosis
Lalowski, M. (Förhandsgranskare), Öhman, T. (Förhandsgranskare), Lahesmaa, R. (Handledare) & Moulder, R. (Handledare)
10 okt. 2018Aktivitet: Examinationstyper › Förhandsgranskare av doktorsavhandling
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Serum Proteomics to Detect Early Changes in Type 1Diabetes and Carotid Atherosclerosis
Lalowski, M. (Förhandsgranskare), Öhman, T. J. (Förhandsgranskare), Lahesmaa, R. (Handledare) & Moulder, R. (Handledare)
maj 2018Aktivitet: Examinationstyper › Handledare eller bihandledare av doktorsavhandling