Organisationsprofil

Organisationsprofil

Varjosalo Lab

Our longstanding interest is the global and comprehensive understanding of how key cellular signaling molecules; protein kinases, protein phosphatases and transcription factors mediate their signaling potential and how the signaling is changed in diseases in the immuno-oncology axis. For this purpose, we have developed experimental and computational methods to identify the protein-interactions formed by these signaling molecules. Additionally, we employ quantitative mass spectrometry -based proteomics on assessing the protein abundance changes, as well as phosphorylation status of the tissues/cells. Furthermore, combining the data from the different sets of ‘omics’ data (proteomics, HTS and HiSeq), allows us to generate global and systems level understanding on how disease-causing mutations mediate their effects, enabling also the development of therapeutic or diagnostic approaches. Read more on our website.

Internationellt och inhemskt samarbete Publikationer och projekt inom de senaste fem åren.

Projekt

Generation Green

Sikanen, T., Yli-Kauhaluoma, J., Hirvonen, J., Vuorela, P., Kärkkäinen, R., Vuorensola, K., Teppo, J., Salminen, O., Sivula, S. & Teräsalmi, E.

01/01/2015 → …

Projekt: Annan projekt

Genome, transcriptome and proteome of the wood-decay fungus Phlebia radiata

Lundell, T., Kuuskeri, J., Mäkinen, M., Paulin, L., Laine, P., Smolander, O., Varjosalo, M. & Auvinen, P.

03/01/201131/12/2017

Projekt: Forskningsprojekt

Publikationer

  • 88 Artikel
  • 3 Doktorsavhandling
  • 1 Mötesabstrakt
  • 1 Översiktsartikel

Characterization of the clinical and immunological phenotype and management of 157 individuals with 56 distinct heterozygous NFKB1 mutations

Lorenzini, T., Fliegauf, M., Klammer, N., Frede, N., Proietti, M., Bulashevska, A., Camacho-Ordonez, N., Varjosalo, M., Kinnunen, M., de Vries, E., van der Meer, J. W. M., Ameratunga, R., Roifman, C. M., Schejter, Y. D., Kobbe, R., Hautala, T., Atschekzei, F., Schmidt, R. E., Schröder, C., Stepensky, P. & 54 andra, Shadur, B., Pedroza, L. A., van der Flier, M., Martínez-Gallo, M., Gonzalez-Granado, L. I., Allende, L. M., Shcherbina, A., Kuzmenko, N., Zakharova, V., Neves, J. F., Svec, P., Fischer, U., Ip, W., Bartsch, O., Barış, S., Klein, C., Geha, R., Chou, J., Alosaimi, M., Weintraub, L., Boztug, K., Hirschmugl, T., Dos Santos Vilela, M. M., Holzinger, D., Seidl, M., Lougaris, V., Plebani, A., Alsina, L., Piquer-Gibert, M., Deyà-Martínez, A., Slade, C. A., Aghamohammadi, A., Abolhassani, H., Hammarström, L., Kuismin, O., Helminen, M., Allen, H. L., Thaventhiran, J. E., Freeman, A. F., Cook, M., Bakhtiar, S., Christiansen, M., Cunningham-Rundles, C., Patel, N. C., Rae, W., Niehues, T., Brauer, N., Syrjänen, J., Seppänen, M. R. J., Burns, S. O., Tuijnenburg, P., Kuijpers, T. W., Warnatz, K. & Grimbacher, B., 9 apr 2020, I : Journal of Allergy and Clinical Immunology.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Design, Synthesis and Characterization of a PEGylated Stanozolol for Potential Therapeutic Applications

Vergallo, C., Torrieri, G., Provenzani, R., Miettinen, S., Moslova, K., Varjosalo, M., Cristiano, M. C., Fresta, M., Celia, C., Santos, H. A., Cilurzo, F. & Di Marzio, L., 5 jan 2020, I : International Journal of Pharmaceutics. 573, 11 s., 118826.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Electrical synapses interconnecting axons revealed in the optic nerve head – a novel model of gap junctions’ involvement in optic nerve function

Smedowski, A., Akhtar, S., Liu, X., Pietrucha-Dutczak, M., Podracka, L., Toropainen, E., Alkanaan, A., Ruponen, M., Urtti, A., Varjosalo, M., Kaarniranta, K. & Lewin-Kowalik, J., jun 2020, I : Acta Ophthalmologica. 98, 4, s. 408-417 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Öppen tillgång
Fil

High-Resolution Confocal Fluorescence Imaging of Serine Hydrolase Activity in Cryosections - Application to Glioma Brain Unveils Activity Hotspots Originating from Tumor-Associated Neutrophils

Aaltonen, N., Singha, P. K., Jakupovic, H., Wirth, T., Samaranayake, H., Pasonen-Seppanen, S., Rilla, K., Varjosalo, M., Edgington-Mitchell, L. E., Kasperkiewicz, P., Drag, M., Kälvälä, S., Moisio, E., Savinainen, J. R. & Laitinen, J. T., 15 mar 2020, I : Biological Procedures Online. 22, 1, 21 s., 6.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Öppen tillgång
Fil

Aktiviteter

  • 1 Förhandsgranskare av doktorsavhandling
  • 1 Handledare eller bihandledare av doktorsavhandling
  • 1 Akademisk besök på annan institution

Serum proteomics to detect early changes in type 1 diabetes and carotid atherosclerosis

Maciej Lalowski (Förhandsgranskare), , Tiina Öhman (Förhandsgranskare), , Riitta Lahesmaa (Handledare), & Robert Moulder (Handledare)

10 okt 2018

Aktivitet: ExaminationstyperFörhandsgranskare av doktorsavhandling

Serum Proteomics to Detect Early Changes in Type 1Diabetes and Carotid Atherosclerosis

Maciej Lalowski (Förhandsgranskare), , Tiina Johanna Öhman (Förhandsgranskare), , Riitta Lahesmaa (Handledare), & Robert Moulder (Handledare)

maj 2018

Aktivitet: ExaminationstyperHandledare eller bihandledare av doktorsavhandling

Karolinska Institutet, Department of Medical Biochemistry and Biophysics

Jaakko Teppo (Besökande forskare)

2 nov 20174 dec 2017

Aktivitet: Typer för besök till extern institutionAkademisk besök på annan institution