Projekt per år
Organisationsprofil
Organisationsprofil
The research team investigates molecular mechanisms underlying neurodevelopmental disorders, especially mechanisms causing features requiring treatment such as challenging behavioural problems in fragile X syndrome (FXS) and autism related disorders. The ultimate goal is to develop improved treatment strategies for these disorders. The team uses patient-specific induced pluripotent stem cells (iPSCs) for disease modelling in dish. Studies explore alterations of functional responses in iPSC-derived neuronal cells in a cell type-dependent manner and explore contribution of astrocytes to impaired neuronal network function.
Previous work of the lab has functionally characterized differentiation of glutamate-responsive human and mouse neural progenitors and demonstrated aberrances during early stages of neuronal cell differentiation in FXS. The recently published studies revealed enhanced intracellular Ca2+ responses to AMPA receptor activation in neural progenitors differentiated from human iPSCs generated from somatic cells of FXS males compared to controls. Increased Ca2+-permeable AMPA receptor (CP-AMPAR) activity associates with increased Ca2+ influx via L-type voltage-gated calcium channels and augmented responses to membrane depolarization and to NMDA and type I metabotropic glutamate receptor activation. Changes of Ca2+ dynamics affect fate determination, differentiation, and migration of FXS neural progenitors. Increased Ca2+ influx through CP-AMPARs renders neural progenitors more susceptible to excitotoxicity. Increased vulnerability may act as a selective factor during cell differentiation and interfere with establishment of neocortical circuits leading to network hyperexcitability in FXS brain.
Internationellt och inhemskt samarbete
Publikationer och projekt inom de senaste fem åren.
Personer
Maija Castrén, Senior Researcher
- Avdelningen för fysiologi - Docent, äldre forskare
- NeuroDevDiseaseModelling
- Doctoral Programme Brain & Mind - Handledare för doktorandprogram
- Medicum - gästforskare, Forskningsledare (Principal Investigator)
Person: gästforskare, U3 Undervisnings- och forskningspersonal, HU, undervisnings- och forskningspersonal
Projekt
- 1 Slutfört
NeuroASD: Activity dependent defects of Neuronal specification and circuit formation in Autism Spectrum Disorders
01/02/2018 → 31/03/2018
Projekt: Annan projekt
Publikationer
Astrocytes in Neuropathologies Affecting the Frontal Cortex
Peteri, U-K., Niukkanen, M. & Castren, M. L., 12 feb 2019, I : Frontiers in Cellular Neuroscience. 13, 9 s., 44.Forskningsoutput: Tidskriftsbidrag › Översiktsartikel › Vetenskaplig › Peer review
Öppen tillgång
Fil
Autismikirjo: Tausta, diagnostiikka ja tutkimus
Timonen, T., Castren, M. & Ärölä-Dithapo, M., 2019, Jyväskylä: PS-kustannus. 381 s.Forskningsoutput: Bok/rapport › Bok
Beneficial Effects of GLP-1 Agonist in a Male With Compulsive Food-Related Behavior Associated With Autism
Jarvinen, A., Laine, M. K., Tikkanen, R. & Castren, M. L., 1 mar 2019, I : Frontiers in psychiatry. 10, 5 s., 97.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
Öppen tillgång
Fil
Dysregulated Ca2+-Permeable AMPA Receptor Signaling in Neural Progenitors Modeling Fragile X Syndrome
Danesi, C. E., Keinänen, K. P. & Castren, M. L., 8 feb 2019, I : Frontiers in Synaptic Neuroscience. 11, 8 s., 2.Forskningsoutput: Tidskriftsbidrag › Översiktsartikel › Vetenskaplig › Peer review
Öppen tillgång
Fil
Modeling FXS with mouse neural progenitors
Peteri, U-K. A. & Castren, M. L., 2019, Fragile-X Syndrome: Methods and Protocols. Ben-Yosef, D. & Mayshar, Y. (red.). New York, NY: Humana press, s. 71-78 8 s. (Methods in Molecular Biology; vol. 1942).Forskningsoutput: Kapitel i bok/rapport/konferenshandling › Kapitel › Vetenskaplig › Peer review
Aktiviteter
ISSCR 2019 Stem Cells & Organoids in Development & Disease
Ulla-Kaisa Anneli Peteri (Närvarande)20 feb 2019 → 22 feb 2019
Aktivitet: Typer för deltagande i eller organisering av evenemang › Arrangemang av och deltagande i konferens/workshop/kurs/seminarium
Joint Meeting of the Finnish Developmental Biology Society & Finnish Stem Cell Network
Ulla-Kaisa Anneli Peteri (Närvarande)26 okt 2018 → 27 okt 2018
Aktivitet: Typer för deltagande i eller organisering av evenemang › Arrangemang av och deltagande i konferens/workshop/kurs/seminarium
Molecular Mechanisms Involved in Altered Differentiation of Neural Progenitors in Fragile X Syndrome
Maija Castrén (Handledare)27 feb 2018
Aktivitet: Examinationstyper › Handledare eller bihandledare av doktorsavhandling
Expert Evaluator for the Horizon 2020 Marie Sklodowska-Curie Actions Individual Felloships programme (H2020-MSCA-IF)
Maija Castrén (!!Advisor)2018
Aktivitet: Konsulttyper › !!Consultancy
Autism Seminar/Autismiseminaari;tiede ja yhteiskunta
Maija Castrén (Talare: Presentation)11 sep 2018
Aktivitet: Typer för deltagande i eller organisering av evenemang › Arrangemang av och deltagande i konferens/workshop/kurs/seminarium
Tidningsurklipp
Autismin kirjolla - monimuotoisia häiriöitä, kehityksellisiä ongelmia, mutta myös erityislahjakkuutta
07/05/2019
1 objekt av Mediabevakning
Press/media: !!Press / Media