Sanna Lehtonen research group

  • Haartmaninkatu 3, B241

    00014 Helsingin yliopisto

Publikationer 1998 2019

2019

Editorial: Podocyte Pathology and Nephropathy-An Update

Lehtonen, S. & Lewko, B., 30 jul 2019, I : Frontiers in Endocrinology. 10, 3 s., 528.

Forskningsoutput: TidskriftsbidragLedareVetenskapligPeer review

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Metformin increases glucose uptake and acts renoprotectively by reducing SHIP2 activity

Polianskyte-Prause, Z., Tolvanen, T. A., Lindfors, S., Dumont, V., Van, M., Wang, H., Dash, S. N., Berg, M., Naams, J-B., Hautala, L. C., Nisen, H., Mirtti, T., Groop, P-H., Wähälä, K., Tienari, J. & Lehtonen, S., feb 2019, I : FASEB Journal. 33, 2, s. 2858-2869 12 s.

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SHIPping out diabetes-Metformin, an old friend among new SHIP2 inhibitors

Lehtonen, S., 12 aug 2019, I : Acta Physiologica. 22 s., 13349.

Forskningsoutput: TidskriftsbidragÖversiktsartikelVetenskapligPeer review

2018

Glucose Transporters in Diabetic Kidney Disease-Friends or Foes?

Wasik, A. A. & Lehtonen, S., 9 apr 2018, I : Frontiers in Endocrinology. 9, 12 s., 155.

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2017

Inhibition of SHIP2 in CD2AP-deficient podocytes ameliorates reactive oxygen species generation but aggravates apoptosis

Saurus, P., Tolvanen, T. A., Lindfors, S., Kuusela, S., Holthofer, H., Lehtonen, E. & Lehtonen, S., 6 sep 2017, I : Scientific Reports. 7, 14 s., 10731.

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Metformin and the catalytic activity of SHIP2

Berg, M. E. A., Tolvanen, T. A., Polianskyte-Prause, Z., Lindfors, S. H., Wähälä, K. & Lehtonen, S. H., 27 aug 2017, s. 125. 1 s.

Forskningsoutput: KonferensbidragPosterForskning

PACSIN2 accelerates nephrin trafficking and is up-regulated in diabetic kidney disease

Dumont, V., Tolvanen, T. A., Kuusela, S., Wang, H., Nyman, T. A., Lindfors, S., Tienari, J., Nisén, H., Suetsugu, S., Plomann, M., Kawachi, H. & Lehtonen, S., sep 2017, I : FASEB Journal. 31, 18 s.

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Septin 7 reduces nonmuscle myosin IIA activity in the SNAP23 complex and hinders GLUT4 storage vesicle docking and fusion

Wasik, A., Dumont, V., Tienari, J-P., Nyman, T. A., Fogarty, C., Forsblom, C., Lehto, M., Lehtonen, E., Groop, P-H. & Lehtonen, S., 15 jan 2017, I : Experimental Cell Research. 350, 2, s. 336-348 13 s.

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Sticklebacks adapted to divergent osmotic environments show differences in plasticity for kidney morphology and candidate gene expression

Hasan, M. M., De Faveri, J., Kuure, S., Dash, S. N., Lehtonen, S., Merila, J. & McCairns, R. J. S., 15 jun 2017, I : Journal of Experimental Biology. 220, 12, s. 2175-2186 12 s.

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The Roles of CD2AP and SHIP2 in insulin resistance and podocyte apoptosis

Tolvanen, T. A., 18 dec 2017, Helsinki : [T. A. Tolvanen]. 95 s.

Forskningsoutput: AvhandlingDoktorsavhandlingSamling av artiklar

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2016

Cu-Catalyzed ligand-free synthesis of rosuvastatin based novel indole derivatives as potential anticancer agents

Kumar, K. S., Rajesham, B., Ramulu, M. S., Bhaskar, B., Dash, S. N., Ashfaq, M. A., Nagarapu, R., Khan, A. A., Lehtonen, S. & Pal, M., 2016, I : RSC Advances. 6, 102, s. 100487-100493 7 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Cyclin-dependent kinase 2 protects podocytes from apoptosis

Saurus, P., Kuusela, S., Dumont, V., Lehtonen, E., Fogarty, C. L., Lassenius, M. I., Forsblom, C., Lehto, M., Saleem, M. A., Groop, P-H. & Lehtonen, S., 15 feb 2016, I : Scientific Reports. 6, 14 s., 21664.

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Data supporting the regulation of FOXC2 in podocyte dysfunction

Datta, N., Lindfors, S., Miura, N., Saleem, M. A. & Lehtonen, S., 2016, I : Data in Brief. 6, s. 514 - 520 7 s.

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Overexpression of transcription factor FOXC2 in cultured human podocytes upregulates injury markers and increases motility

Datta, N., Lindfors, S., Miura, N., Saleem, M. A. & Lehtonen, S., 1 jan 2016, I : Experimental Cell Research. 340, 1, s. 32-42 11 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Regulation of podocyte apoptosis in diabetic kidney disease : role of SHIP2, PDK1 and CDK2

Saurus, P., 2016, Helsinki: University of Helsinki. 98 s.

Forskningsoutput: AvhandlingDoktorsavhandlingSamling av artiklar

sept7b is required for the differentiation of pancreatic endocrine progenitors

Dash, S., Hakonen, E., Ustinov, J., Otonkoski, T., Andersson, O. & Lehtonen, S., 26 apr 2016, I : Scientific Reports. 6, 14 s., 24992.

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Tankyrase inhibition aggravates kidney injury in the absence of CD2AP

Kuusela, S., Wang, H., Wasik, A., Suleiman, H. & Lehtonen, S., jul 2016, I : Cell Death and Disease. 7, 13 s.

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2015

A novel mechanism of action of metformin to ameliorate peripheral insulin resistance

Tolvanen, T. A., Polianskyte-Prause, Z., Lindfors, S. H., Wähälä, K. & Lehtonen, S. H., 2015, Emerging targets and molecules in middle space: Program & Abstracts. Wähälä, K., Koistinen, H. & Koskinen, A. (red.). Helsinki: FInMedChem FInnish Pharmaceutical Society , 1 s.

Forskningsoutput: Kapitel i bok/rapport/konferenshandlingKonferensbidragVetenskaplig

Early-Onset Diabetic E1-DN Mice Develop Albuminuria and Glomerular Injury Typical of Diabetic Nephropathy

Hyvonen, M. E., Dumont, V., Tienari, J., Lehtonen, E., Ustinov, J., Havana, M., Jalanko, H., Otonkoski, T., Miettinen, P. J. & Lehtonen, S., 2015, I : BioMed Research International. 11 s., 102969.

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Lack of CD2AP disrupts Glut4 trafficking and attenuates glucose uptake in podocytes

Tolvanen, T., Dash, S. N., Polianskyte-Prause, Z., Dumont, V. & Lehtonen, S., 2015, I : Journal of Cell Science. 128, 24, s. 4588-4600 13 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Podocyte apoptosis is prevented by blocking the Toll-like receptor pathway

Saurus, P., Kuusela, S., Lehtonen, E., Hyvönen, M. E., Ristola, M., Fogarty, C. L., Tienari, J., Lassenius, M. I., Forsblom, C., Lehto, M., Saleem, M. A., Groop, P-H., Holthofer, H. & Lehtonen, S., maj 2015, I : Cell Death and Disease. 6, 12 s., 1752.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Predictive role of toll-like receptors 2, 4, and 9 in oral tongue squamous cell carcinoma

Makinen, L. K., Atula, T., Häyry, J. H. V., Jouhi, L., Datta, N., Lehtonen, S., Abdirisak, A., Makitie, A. A., Haglund, C. & Hagstrom, J., jan 2015, I : Oral Oncology. 51, 1, s. 96-102 7 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Tankyrases regulate glucoregulatory mechanisms and somatic growth via the central melanocortin system in zebrafish larvae

Wang, H., Semenova, S., Kuusela, S., Panula, P. & Lehtonen, S., nov 2015, I : FASEB Journal. 29, 11, s. 4435-4448 14 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2014

Ezrin Is Down-Regulated in Diabetic Kidney Glomeruli and Regulates Actin Reorganization and Glucose Uptake via GLUT1 in Cultured Podocytes

Wasik, A. A., Koskelainen, S., Hyvonen, M. E., Musante, L., Lehtonen, E., Koskenniemi, K., Tienari, J., Vaheri, A., Kerjaschki, D., Szalay, C., Revesz, C., Varmanen, P., Nyman, T. A., Hamar, P., Holthofer, H. & Lehtonen, S., jun 2014, I : The American Journal of Pathology. 184, 6, s. 1727-1739 13 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Functions of the podocyte proteins nephrin and Neph3 and the transcriptional regulation of their genes

Ristola, M. & Lehtonen, S., mar 2014, I : Clinical Science. 126, 5-6, s. 315-328 14 s.

Forskningsoutput: TidskriftsbidragÖversiktsartikelVetenskapligPeer review

sept7b is essential for pronephric function and development of left-right asymmetry in zebrafish embryogenesis

Dash, S. N., Lehtonen, E., Wasik, A. A., Schepis, A., Paavola, J., Panula, P., Nelson, W. J. & Lehtonen, S., 1 apr 2014, I : Journal of Cell Science. 127, 7, s. 1476-1486 11 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2013

CD2AP is associated with end-stage renal disease in patients with type 1 diabetes

Hyvönen, M. E., Ihalmo, P., Sandholm, N., Stavarachi, M., Forsblom, C., McKnight, A. J., Lajer, M., Maestroni, A., Lewis, G., Tarnow, L., Maestroni, S., Zerbini, G., Parving, H-H., Maxwell, A. P., Groop, P-H. & Lehtonen, S., dec 2013, I : Acta Diabetologica. 50, 6, s. 887-897 11 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Experimental and genetic studies on podocyte molecules CD2AP and SHIP2 in diabetic nephropathy

Hyvönen, M., 2013, Helsinki: [M. Hyvönen]. 109 s.

Forskningsoutput: AvhandlingDoktorsavhandlingSamling av artiklar

Regulation of nephrin gene by the Ets transcription factor, GA-binding protein

Ristola, M., Arpiainen, S., Shimokawa, T., Ra, C., Tienari, J-P., Saleem, M. A., Holthofer, H. & Lehtonen, S., apr 2013, I : Nephrology, Dialysis, Transplantation. 28, 4, s. 846-855 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Report of the Second European Zebrafish Principal Investigator Meeting in Karlsruhe, Germany, March 21-24, 2012

Cavodeassi, F., Del Bene, F., Fuerthauer, M., Grabher, C., Herzog, W., Lehtonen, S., Linker, C., Mercader, N., Mikut, R., Norton, W., Straehle, U., Tiso, N. & Foulkes, N. S., mar 2013, I : Zebrafish. 10, 1, s. 119-123 5 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2012

INPPL1 is associated with the metabolic syndrome in men with Type 1 diabetes, but not with diabetic nephropathy

Hyvonen, M. E., Ihalmo, P., Forsblom, C., Thorn, L., Sandholm, N., Lehtonen, S. & Groop, P. -H., dec 2012, I : Diabetic Medicine. 29, 12, s. 1589-1595 7 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Kidney filtration barrier components nephrin and Neph3 : transcriptional regulation and role in cell adhesion

Ristola, M., 2012, Helsinki: University of Helsinki. 100 s.

Forskningsoutput: AvhandlingDoktorsavhandlingSamling av artiklar

Neph3 associates with regulation of glomerular and neural development in zebrafish

Wang, H., Lehtonen, S., Chen, Y., Heikkilä, E. K., Panula, P. & Holthöfer, H., 2012, I : Differentiation. 83, s. 38-46 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Septin 7 forms a complex with CD2AP and nephrin and regulates glucose transporter trafficking

Wasik, A. A., Polianskyte-Prause, Z., Dong, M-Q., Shaw, A. S., Yates, J. R., Farquhar, M. G. & Lehtonen, S., 1 sep 2012, I : Molecular Biology of the Cell. 23, 17, s. 3370-3379 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Transcription of nephrin-Neph3 gene pair is synergistically activated by WT1 and NF-kappa B and silenced by DNA methylation

Ristola, M., Arpiainen, S., Saleem, M. A., Holthöfer, H. & Lehtonen, S., 2012, I : NDT Plus. 27, 5, s. 1737-1745 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2011

Hyperglycaemic E1-DN mice develop albuminuria and glomerular injury

Hyvonen, M. E., Ustinov, J., Otonkoski, T., Miettinen, P. J. & Lehtonen, S., sep 2011, I : Diabetologia. 54, s. S432-S432 1 s.

Forskningsoutput: TidskriftsbidragMötesabstraktForskningPeer review

Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia

Saarikangas, J., Mattila, P. K., Varjosalo, M., Bovellan, M., Hakanen, J., Calzada-Wack, J., Tost, M., Jennen, L., Rathkolb, B., Hans, W., Horsch, M., Hyvönen, M. E., Perälä, N., Fuchs, H., Gailus-Durner, V., Esposito, I., Wolf, E., de Angelis, M. H., Frilander, M. J., Savilahti, H. & 6 andraSariola, H., Sainio, K., Lehtonen, S., Taipale, J., Salminen, M. & Lappalainen, P., 2011, I : Journal of Cell Science. 124, 8, s. 1245-1255 11 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Trans-interaction of nephrin and Neph1/Neph3 induces cell adhesion that associates with decreased tyrosine phosphorylation of nephrin

Heikkilä, E. K., Ristola, M., Havana, M., Jones, N., Holthofer, H. & Lehtonen, S., 2011, I : Biochemical Journal. 435, Part 3, s. 619-628 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2010

beta-Catenin mediates adriamycin-induced albuminuria and podocyte injury in adult mouse kidneys

Heikkila, E., Juhila, J., Lassila, M., Messing, M., Perälä, N., Lehtonen, E., Lehtonen, S., Verbeek, J. S. & Holthofer, H., 2010, I : Nephrology, Dialysis, Transplantation. 25, 8, s. 2437-2446 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Lipid phosphatase SHIP2 downregulates insulin signalling in podocytes

Hyvönen, M. E., Saurus, P., Wasik, A., Heikkilä, E. K., Havana, M., Trokovic, R., Saleem, M., Holthöfer, H. & Lehtonen, S., 2010, I : Molecular and Cellular Endocrinology. 328, 1-2, s. 70-79 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2009

Luentojen vuorovaikutteisuus motivoi opiskelijoita ja luennoitsijoita

Lehtonen, S., Linden, A-M., Ojala, P. M., Polvi, A., Sallinen, V. & Viranta, S., 2009, I : Duodecim. 125, 20, s. 2199-2205 7 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Regulation of Neph3 gene in podocytes - key roles of transcription factors NF-kappaB and Sp1

Ristola, M., Arpiainen, S., Saleem, M. A., Mathieson, P. W., Welsh, G. I., Lehtonen, S. & Holthöfer, H., 2009, I : BMC Molecular Biology. 10, s. 83 12 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2004

Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin

Lehtonen, S., Lehtonen, S., Lehtonen, E., Kudlicka, K., Holthofer, H. & Farquhar, M. G., 2004, I : The American Journal of Pathology. 165, s. 923-936 14 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Subfamily III of mammalian oxysterol-binding protein (OSBP) homologues: the expression and intracellular localization of ORP3, ORP6, and ORP7

Lehto, M., Tienari, J., Lehtonen, S., Lehtonen, E. & Olkkonen, V. M., 2004, I : Cell and Tissue Research. 315, s. 39-57 19 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review