Adrian Goldman

professor, Forskningsprogrammet för molekylära och integrativa biovetenskaper
Handledare för doktorandprogram, Doctoral Programme Brain & Mind
Handledare för doktorandprogram, Doctoral Programme in Integrative Life Science

Telefon+358504486378, +358294158908
E-postadrian.goldman@helsinki.fi

PL 65 (Viikinkaari 9)
00014
Finland
Viikinkaari 5, Biocenter 2
00790 Helsinki
Finland

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Personlig profil

Information om forskning och undervisning

More than 50% of current drugs affect membrane proteins and membrane protein systems. It is thus clear that membranes and the proteins embedded in/associated with them are key both biologically and medicinally. The proteins and protein complexes in the membrane create electrochemical gradients, mediate self:non-self interactions, and control the passage of molecules and responses to extracellular signals. Despite this, such systems have been less thoroughly studied than soluble proteins (Engelman, 2005, Nature, 438, 578-80). Steady advances in techniques have made it possible to study them in lower amounts and with more spatial and temporal precision than before.

Our work, which aims at spatial cellular/structural biology, thus focuses on proteins and protein complexes that are at and close to the cell surface, looking at at neuronal protein interactions (e.g. GDNF-GFRα-RET, MANF, and neuronal LRR-proteins) and at host-pathogen interactions, such as those involving trimeric autotransporters, factor H and complement.

Externa befattningar

PI, Marie Curie ITN ViBrANT

1 jan 2018 → 31 dec 2021

coPI, Marie Curie ITN RAMP

1 apr 2017 → 31 mar 2021

Vetenskapsgrenar

1182 Biokemi, cell- och molekylärbiologi

Internationellt och inhemskt samarbete Publikationer och projekt inom de senaste fem åren.

Publikationer 2003 2019

81 Artikel
4 Kapitel
4 Översiktsartikel
1 Konferensbidrag
2 Mer
- 1 Mötesabstrakt
- 1 Ledare

Asymmetry in catalysis by Thermotoga maritima membrane-bound pyrophosphatase demonstrated by a nonphosphorus allosteric inhibitor

Vidilaseris, K., Kiriazis, A., Turku, A., Khattab, A. A. S., Johansson, N. G., Leino, T. O., Kiuru, P. S., Boije af Gennäs, P. G., Meri, S. K., Yli-Kauhaluoma, J. T., Xhaard, H. G. M. & Goldman, A., 22 maj 2019, I : Science Advances. 5, 5, 12 s., 7574.

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

Öppen tillgång

Fil

Roles of the Hydrophobic Gate and Exit Channel in Vigna radiata Pyrophosphatase Ion Translocation

Tsai, J-Y., Tang, K-Z., Li, K-M., Hsu, B-L., Chiang, Y-W., Goldman, A. & Sun, Y-J., 5 apr 2019, I : Journal of Molecular Biology. 431, 8, s. 1619-1632 14 s.

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review