Foto av Alex Edwin Bunker

Alex Edwin Bunker

Adjunct Professor, Department of Chemistry, Faculty of Science

  • PL 56 (Viikinkaari 5)

    00014

    Finland

20052020

Forskningsoutput per år

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Personlig profil

Information om forskning och undervisning

Research:

Myself, along with Dr. Tapani Viitala, share leadership of the Pharmaceutical Biophysics group. Our research combines my computational research methodologies with the experimental research methodologies of Dr. Tapani Viitala, to the development of a mechanistic understanding of the interactions between the three fundamental elements of bionanovectors: lipid membranes, proteins and polymers. We study their behaviour in the bloodstream and, on a more general level, the design principles of safe and efficient drug delivery systems and their interaction with biological membranes and cells. The group is founded on the combined expertise of the two principle investigators with established track records in this field: the experimental research of Dr. Tapani Viitala and the computational research of Dr. Alex Bunker. The combination provides a synergistic framework that, as collaboration, has already provided new insights from new combined experimental-computational methodologies for the analysis of these systems.

Teaching:

I currently teach two courses “advanced mathematical tools for pharmaceutical research” Course #590337 and “Fundamentals of Molecular Modelling and drug design” Course #590287, both at the faculty of pharmacy. Course #590337 is an refresher course in the applied mathematical tools needed for pharmacy research in areas including physical pharmacy, pharmacokinetics and molecular modelling. Course #590287 is an introductory course in molecular modelling taught from the ground up to give the students who have no initial background a basic understanding of the growing use of molecular modelling techniques in pharmaceutical research. 

Meritförteckning

Tekstiä

Vetenskapsgrenar

  • 317 Farmaci
  • 114 Fysik
  • 118 Biovetenskaper
  • 116 Kemi
  • 221 Nanoteknologi

Internationellt och inhemskt samarbete Publikationer och projekt inom de senaste fem åren.

Publikationer

Bitopic and Peripheral Membrane Proteins as Drug Targets: Broader Biophysical Insight from Biomembrane Simulations that Transcends the "Lock and Key'' Paradigm

Bunker, A., 7 feb 2020, I : Biophysical Journal. 118, 3, s. 160A-160A 1 s.

Forskningsoutput: TidskriftsbidragMötesabstraktForskningPeer review

Cholesterol Reduces Partitioning of Antifungal Drug Itraconazole into Lipid Bilayers

Poojari, C., Zak, A., Dzieciuch-Rojek, M., Bunker, A., Kepczynski, M. & Rog, T., 19 mar 2020, I : Journal of Physical Chemistry B. 124, 11, s. 2139-2148 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

In Vitro and in Vivo Behavior of Liposomes Decorated with PEGs with Different Chemical Features

Mastrotto, F., Brazzale, C., Bellato, F., De Martin, S., Grange, G., Mahmoudzadeh, M., Magarkar, A., Bunker, A., Salmaso, S. & Caliceti, P., feb 2020, I : Molecular Pharmaceutics. 17, 2, s. 472-487 16 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

A potent partial agonist of PKC orients in membranes like the biological activator diacylglycerol

Lautala, S., Koivuniemi, A., Kulig, W., Rog, T., Talman, V., Tuominen, R. & Bunker, A., jul 2019, I : European Biophysics Journal. 48, s. S122-S122 1 s.

Forskningsoutput: TidskriftsbidragMötesabstraktForskningPeer review

Öppen tillgång
Fil

Projekter

Medimmune collaboration research

Bunker, A. E. & Magarkar, A.

01/05/201630/09/2016

Projekt: Forskningsprojekt

Molecular dynamics simulation as a tool to investigate novel formulations for –some based drug delivery systems

Bunker, A. E., Magarkar, A., Karhu, L., Momeni, S. & Mahmoudzadeh, M.

01/09/201531/08/2019

Projekt: Forskningsprojekt

Surface Structure of Nanoparticles

Magarkar, A., Bunker, A. E., Urtti, A., Yliperttula, M. & Rog, T.

02/08/201031/08/2015

Projekt: Forskningsprojekt

Molecular dynamics simulation of DNA - dendrimer interactions

Bunker, A. E. & maiti, P.

10/10/200831/12/2015

Projekt: Forskningsprojekt

Aktiviteter

6th European Joint Theoretical Experimental Meeting on Membranes

Tapani Viitala (Ordförande i organisationskommitté), & Alexander Edwin Bunker (Ordförande i organisationskommitté)

12 dec 201814 dec 2018

Aktivitet: Typer för deltagande i eller organisering av evenemangArrangemang av och deltagande i konferens/workshop/kurs/seminarium

ESCDD2016

Alex Edwin Bunker (Poster presentation)

13 apr 201615 apr 2016

Aktivitet: Typer för deltagande i eller organisering av evenemangArrangemang av och deltagande i konferens/workshop/kurs/seminarium

Biopolymers (Tidskrift)

Alex Edwin Bunker (Referentgranskare)

10 nov 2016

Aktivitet: Typer för peer review av output och redaktionsarbeteReferentgranskning av manuskript

Faculty of Pharmacy, Tartu University

Alex Edwin Bunker (Besökande forskare)

2 mar 20163 mar 2016

Aktivitet: Typer för besök till extern institutionAkademisk besök på annan institution

Langmuir (Tidskrift)

Alex Edwin Bunker (Referentgranskare)

20 jul 2016

Aktivitet: Typer för peer review av output och redaktionsarbeteReferentgranskning av manuskript

Tidningsurklipp

Interview for article in "Inside Science"

Alex Edwin Bunker

25/08/2016

1 Mediabidrag

Press/media: !!Press / Media