Forskningsresultat per år
Forskningsresultat per år
- 25 resultat
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2023
Hydroxychloroquine is Metabolized by Cytochrome P450 2D6, 3A4 and 2C8, and Inhibits Cytochrome P450 2D6, while its Metabolites also Inhibit Cytochrome P450 3A in vitro
Paludetto, M-N. I. A., Kurkela, M., Kahma, H., Backman, J. T., Niemi, M. & Filppula, A. M., 1 mars 2023, I: Drug Metabolism and Disposition. 51, 3, s. 293-305 13 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Rhabdomyolysis during concomitant ticagrelor and rosuvastatin: A breast cancer resistance protein-mediated drug interaction?
Lehtisalo, M., Kiander, W., Filppula, A. M., Deng, F., Kidron, H., Korhonen, M., Sinkko, J., Koivula, K. & Niemi, M., 20 feb. 2023, I: British Journal of Clinical Pharmacology. 7 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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2022
Hydroxychloroquine is metabolized by CYP2D6, CYP3A4 and CYP2C8, and inhibits CYP2D6, while its metabolites also inhibit CYP3A4 in vitro
Paludetto, M-N. I. A., Kurkela, M., Kahma, H., Backman, J., Niemi, M. & Filppula, A. M., 7 juni 2022.Forskningsoutput: Konferensbidrag › Sammanfattning
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Hydroxychloroquine is metabolized by CYP2D6, CYP3A4 and CYP2C8, and inhibits CYP2D6 in vitro
Paludetto, M-N. I. A., Kurkela, M., Kahma, H., Backman, J., Niemi, M. & Filppula, A. M., 2022, (!!Unpublished).Forskningsoutput: Konferensbidrag › Poster
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Translational aspects of cytochrome P450-mediated drug-drug interactions: A case study with clopidogrel
Tornio, A., Filppula, A. M. & Backman, J. T., jan. 2022, I: Basic & Clinical Pharmacology & Toxicology. 130, s. 48-59 12 s.Forskningsoutput: Tidskriftsbidrag › Översiktsartikel › Peer review
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2021
An automated cocktail method for in vitro assessment of direct and time-dependent inhibition of nine major cytochrome P450 enzymes-application to establishing CYP2C8 inhibitor selectivity
Kahma, H., Aurinsalo, L., Neuvonen, M., Katajamäki, J., Paludetto, M-N., Viinamäki, J., Launiainen, T., Filppula, A. M., Tornio, A., Niemi, M. & Backman, J. T., 1 juli 2021, I: European Journal of Pharmaceutical Sciences. 162, 14 s., 105810.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Comparative Hepatic and Intestinal Efflux Transport of Statins
Deng, F., Tuomi, S-K., Neuvonen, M., Hirvensalo, P., Kulju, S., Wenzel, C., Oswald, S., Filppula, A. M. & Niemi, M., 1 sep. 2021, I: Drug Metabolism and Disposition. 49, 9, s. 750-759 10 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Comparative Hepatic and Intestinal Metabolism and Pharmacodynamics of Statins
Filppula, A. M., Hirvensalo, P., Parviainen, H., Ivaska, V. E., Lönnberg, K. I., Deng, F., Viinamäki, J., Kurkela, M., Neuvonen, M. & Niemi, M., 1 aug. 2021, I: Drug Metabolism and Disposition. 49, 8, s. 658-667 10 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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2019
Clinical Studies on Drug-Drug Interactions Involving Metabolism and Transport: Methodology, Pitfalls, and Interpretation
Tornio, A., Filppula, A. M., Niemi, M. & Backman, J. T., juni 2019, I: Clinical Pharmacology and Therapeutics. 105, 6, s. 1345-1361 17 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8
Kahma, H., Filppula, A. M., Launiainen, T., Viinamäki, J., Neuvonen, M., Evangelista, E. A., Totah, R. A. & Backman, J. T., 1 apr. 2019, I: Drug Metabolism and Disposition. 47, 4, s. 436-443 8 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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2018
Clopidogrel but Not Prasugrel Significantly Inhibits the CYP2C8-Mediated Metabolism of Montelukast in Humans.
Itkonen, M. K., Tornio, A., Filppula, A. M., Neuvonen, M., Neuvonen, P. J., Niemi, M. & Backman, J. T., sep. 2018, I: Clinical Pharmacology and Therapeutics. 104, 3, s. 495-504 10 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Clopidogrel Carboxylic Acid Glucuronidation is Mediated Mainly by UGT2B7, UGT2B4, and UGT2B17: Implications for Pharmacogenetics and Drug-Drug Interactions
Kahma, H., Filppula, A. M., Neuvonen, M., Tarkiainen, E. K., Tornio, A., Holmberg, M. T., Itkonen, M. K., Finel, M., Neuvonen, P. J., Niemi, M. & Backman, J. T., 1 feb. 2018, I: Drug Metabolism and Disposition. 46, 2, s. 141-150 10 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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In Vitro Screening of Six Protein Kinase Inhibitors for Time-Dependent Inhibition of CYP2C8 and CYP3A4: Possible Implications with regard to Drug-Drug Interactions
Filppula, A. M., Mustonen, T. M. & Backman, J. T., dec. 2018, I: Basic & Clinical Pharmacology & Toxicology. 123, 6, s. 739-748 10 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Potentially dangerous drug-drug interaction between aprepitant and trabectedin
Filppula, A. M., 2018.Forskningsoutput: Konferensbidrag › Poster › Peer review
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The protein kinase inhibitors midostaurin and nintedanib are time-dependent inhibitors of CYP3A4
Filppula, A. M., Mustonen, T. M. & Backman, J. T., 23 mars 2018.Forskningsoutput: Konferensbidrag › Poster › Peer review
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2016
Neurotoxicity and low paclitaxel clearance associated with concomitant clopidogrel therapy in a 60-year-old Caucasian woman with ovarian carcinoma
Bergmann, T. K., Filppula, A. M., Launiainen, T., Nielsen, F., Backman, J. T. & Brosen, K., feb. 2016, I: British Journal of Clinical Pharmacology. 81, 2, s. 313-315 3 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions
Backman, J. T., Filppula, A. M., Niemi, M. & Neuvonen, P. J., jan. 2016, I: Pharmacological Reviews. 68, 1, s. 168-241 74 s.Forskningsoutput: Tidskriftsbidrag › Översiktsartikel › Peer review
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2014
Glucuronidation Converts Clopidogrel to a Strong Time-Dependent Inhibitor of CYP2C8: A Phase II Metabolite as a Perpetrator of Drug-Drug Interactions
Tornio, A., Filppula, A. M., Kailari, O., Neuvonen, M., Nyrönen, T. H., Tapaninen, T., Neuvonen, P. J., Niemi, M. & Backman, J. T., okt. 2014, I: Clinical Pharmacology and Therapeutics. 96, 4, s. 498-507 10 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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In Vitro Assessment of Time-Dependent Inhibitory Effects on CYP2C8 and CYP3A Activity by Fourteen Protein Kinase Inhibitors
Filppula, A. M., Neuvonen, P. J. & Backman, J. T., juli 2014, I: Drug Metabolism and Disposition. 42, 7, s. 1202-1209 8 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Role of CYP2C8 in the metabolism of montelukast and imatinib: studies in vitro, in silico and in humans
Filppula, A., 2014, Helsinki: [A. Filppula]. 129 s.Forskningsoutput: Avhandling › Doktorsavhandling › Samling av artiklar
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2013
Autoinhibition of CYP3A4 Leads to Important Role of CYP2C8 in Imatinib Metabolism: Variability in CYP2C8 Activity May Alter Plasma Concentrations and Response
Filppula, A. M., Neuvonen, M., Laitila, J., Neuvonen, P. J. & Backman, J. T., jan. 2013, I: Drug Metabolism and Disposition. 41, 1, s. 50-59 10 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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Gemfibrozil impairs imatinib absorption and inhibits the CYP2C8-mediated formation of its main metabolite
Filppula, AM., Tornio, A., Niemi, M., Neuvonen, P. & Backman, JT., sep. 2013, I: Clinical Pharmacology and Therapeutics. 94, 3, s. 383-393 11 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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2012
Potent mechanism-based inhibition of CYP3A4 by imatinib explains its liability to interact with CYP3A4 substrates
Filppula, A. M., Laitila, J., Neuvonen, P. J. & Backman, J. T., 2012, I: British Journal of Pharmacology. 165, 8, s. 2787-2798 12 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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2011
Reevaluation of the Microsomal Metabolism of Montelukast: Major Contribution by CYP2C8 at Clinically Relevant Concentrations
Filppula, A. M., Laitila, J., Neuvonen, P. J. & Backman, J. T., 2011, I: Drug Metabolism and Disposition. 39 , 5, s. 904-911Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review
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2010
Gemfibrozil Markedly Increases the Plasma Concentrations of Montelukast: A Previously Unrecognized Role for CYP2C8 in the Metabolism of Montelukast
Karonen, T., Filppula, A., Laitila, J., Niemi, M., Neuvonen, P. J. & Backman, J. T., 2010, I: Clinical Pharmacology and Therapeutics. 88, 2, s. 223-230 8 s.Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review