Foto av Anni-Maija Linden

Anni-Maija Linden

  • PL 63 (Haartmaninkatu 8)

    00014

    Finland

  • PL 63 (Haartmaninkatu 8), A230b

    HELSINGIN YLIOPISTO

    Finland

19972020

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Personlig profil

Information om forskning och undervisning

We are interested in neuronal mechanisms of investigational drugs potentially useful in treatment of psychiatric diseases.

Our behavioral neuropharmacology team consists of Anni-Maija Linden, PhD (Pharm), and PhD student Mira Lainiola, M.Sc. Our behavioral team is a part of a larger Neuropsychopharmacological research group (Department of Pharmacology, Faculty of Medicine). Our main projects are listed below. 

Metabotropic glutamate receptors (mGluRs). Glutamate is the main excitatory neurotransmitter in the brain. Pharmacological compounds modulating metabotropic glutamate receptors (mGluRs) can fine tune glutamatergic system when its function is abnormal and therefore could be beneficial in many psychiatric diseases including addiction, depression and schizophrenia. We study how emotional and cognitive behaviors are affected by modulating glutamatergic neurotransmission through metabotropic glutamate receptor 3 (mGlu3R, GRM3). Recent findings indicate an important role for mGluR3 in neuronal plasticity in the prefrontal cortex and hippocampus. We have shown that the lack of mGluR3 produces defects in working memory and alcohol conditioned place preference (Lainiola et al., 2014; Lainiola et al., 2019). Our aim is to study mechanisms how mGluR3-mediated plasticity affects reward memory acquisition and expression to better understand potential of pharmacological ligands modulating mGluR3 in treatment of diseases where reward regulation is aberrant including addiction and depression.

Neuroinflammation in reward. Motivation and reward-related functions are also modulated by inflammatory reactions, such as microglia activation, in the brain. Neuroinflammation regulates neurotransmission in multiple ways and may play a role in the development of depression and addiction. We investigate mechanisms how activation of innate immune system by the Toll-like receptor 4 agonist lipopolysaccharide (LPS) alters reward-related behaviors in preclinical mouse models (Lainiola et al., 2017; Lainiola et al., 2020). 

Vetenskapsgrenar

  • 3111 Biomedicinska vetenskaper

Internationellt och inhemskt samarbete Publikationer och projekt inom de senaste fem åren.

Publikationer

Behavioral responses of mGluR3-KO mice to the lipopolysaccharide-induced innate inflammatory reaction

Lainiola, M., Linden, A-M. & Aitta-aho, T., mar 2020, I : Pharmacology, Biochemistry and Behavior. 190, 8 s., 172852.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Heterogeneous somatostatin-expressing neuron population in mouse ventral tegmental area

Nagaeva, E., Zubarev, I., Gonzales, C. B., Forss, M., Nikouei, K., de Miguel, E., Elsilä, L., Linden, A-M., Hjerling-Leffler, J., Augustine, G. J. & Korpi, E. R., 4 aug 2020, I : eLife. 9, 29 s., 59328.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Öppen tillgång
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Öppen tillgång
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Tankyrase inhibition ameliorates lipid disorder via suppression of PGC-1 alpha PARylation in db/db mice

Wang, H., Kuusela, S., Rinnankoski-Tuikka, R., Dumont, V., Bouslama, R., Ramadan, U. A., Waaler, J., Linden, A-M., Chi, N-W., Krauss, S., Pirinen, E. & Lehtonen, S., aug 2020, I : International Journal of Obesity. 44, 8, s. 1691-1702 12 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Öppen tillgång
Fil

GABA(B) receptor positive allosteric modulators with different efficacies affect neuroadaptation to and self-administration of alcohol and cocaine

de Miguel, E., Vekovischeva, O., Kuokkanen, K., Vesajoki, M., Paasikoski, N., Kaskinoro, J., Myllymäki, M., Lainiola, M., Janhunen, S. K., Hyytiä, P., Linden, A-M. & Korpi, E. R., nov 2019, I : Addiction Biology. 24, 6, s. 1191-1203 13 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Aktiviteter

3rd Nordic Neuroscience Meeting

Anni-Maija Linden (Medlem i organisationskommitté)

12 jun 201914 jun 2019

Aktivitet: Typer för deltagande i eller organisering av evenemangArrangemang av och deltagande i konferens/workshop/kurs/seminarium

Alcoholism: Clinical and Experimental Research (Tidskrift)

Anni-Maija Linden (Referentgranskare)

2019 → …

Aktivitet: Typer för peer review av output och redaktionsarbeteReferentgranskning av manuskript

Trends in Pharmacological Sciences (Tidskrift)

Anni-Maija Linden (Referentgranskare)

2019

Aktivitet: Typer för peer review av output och redaktionsarbeteReferentgranskning av manuskript

Neuroscience (Tidskrift)

Anni-Maija Linden (Referentgranskare)

2019

Aktivitet: Typer för peer review av output och redaktionsarbeteReferentgranskning av manuskript

Drug Development Research (Tidskrift)

Anni-Maija Linden (Referentgranskare)

2019

Aktivitet: Typer för peer review av output och redaktionsarbeteReferentgranskning av manuskript