Foto på Anni-Maija Linden

Anni-Maija Linden

  • PL 63 (Haartmaninkatu 8)

    00014

    Finland

  • PL 63 (Haartmaninkatu 8), A230b

    HELSINGIN YLIOPISTO

    Finland

19972019
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Personlig profil

Information om forskning och undervisning

Research

I am interested in pharmacology and neuronal mechanisms of psychiatric diseases. The focus of our research group is on studying how brain functions are affected by modulating glutamatergic neurotransmission. Glutamate is the main excitatory neurotransmitter in the brain and therefore its modulation easily causes severe disturbances in normal functions of the central nervous system. Pharmacological compounds which could fine tune glutamatergic system when its function is abnormal would be beneficial in many psychiatric diseases.

Our aim is to study the effects of investigational drugs affecting metabotropic glutamate receptors (mGlu receptors). We use pharmacological tools and behavioral models to analyze brain functions related to cognition and emotions. Our aim is also to correlate behavioral changes induced by pharmacological agents, for example mGlu receptor agonists and antagonists, to activation and neurochemical changes in specific neuronal populations in the brain.  

 

Teaching

As a university lecturer, I participate in teaching pharmacology to medical and dental students at the Faculty of Medicine. Our teaching covers basic preclinical pharmacology and includes lectures as well as problem based learning small group teaching. In addition, I take part in organizing every 2nd year an advanced course on neuropharmacology to Ph.D. students

Vetenskapsgrenar

  • 3111 Biomedicinska vetenskaper

Internationellt och inhemskt samarbete Publikationer och projekt inom de senaste fem åren.

Publikationer 1997 2019

GABA(B) receptor positive allosteric modulators with different efficacies affect neuroadaptation to and self-administration of alcohol and cocaine

de Miguel, E., Vekovischeva, O., Kuokkanen, K., Vesajoki, M., Paasikoski, N., Kaskinoro, J., Myllymäki, M., Lainiola, M., Janhunen, S. K., Hyytiä, P., Linden, A-M. & Korpi, E. R., nov 2019, I : Addiction Biology. 24, 6, s. 1191-1203 13 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Conditioned Reward of Opioids, but not Psychostimulants, is Impaired in GABA-A Receptor δ Subunit Knockout Mice

Siivonen, M. S., de Miguel, E., Aaltio, J., Manner, A. K., Vahermo, M., Yli-Kauhaluoma, J., Linden, A-M., Aitta-aho, T. & Korpi, E. R., 9 okt 2018, I : Basic & Clinical Pharmacology & Toxicology. 123, 5, s. 558-566 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Alcohol intake in two different mouse drinking models after recovery from the lipopolysaccharide-induced sickness reaction

Lainiola, M. & Linden, A-M., dec 2017, I : Alcohol (New York). 65, s. 1-10 10 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Öppen tillgång
Fil

Continuous delivery of naltrexone and nalmefene leads to tolerance in reducing alcohol drinking and to supersensitivity of brain opioid receptors

Korpi, E. R., Linden, A-M., Hytönen, H. R., Paasikoski, N., Vashchinkina, E., Dudek, M., Herr, D. & Hyytiä, P., 2017, I : Addiction Biology. 22, 4, s. 1022-1035 14 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Increased Motor-Impairing Effects of the Neuroactive Steroid Pregnanolone in Mice with Targeted Inactivation of the GABA(A) Receptor gamma 2 Subunit in the Cerebellum

Leppa, E., Linden, A-M., Aller, M. I., Wulff, P., Vekovischeva, O., Luscher, B., Lueddens, H., Wisden, W. & Korpi, E. R., 27 okt 2016, I : Frontiers in Pharmacology. 7, 11 s., 403.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Öppen tillgång
Fil

Aktiviteter 2004 2016

Pre-examiner of doctoral thesis

Anni-Maija Linden (Förhandsgranskare)
18 mar 201630 apr 2016

Aktivitet: ExaminationstyperFörhandsgranskare av doktorsavhandling

Pre-examiner of doctoral thesis

Anni-Maija Linden (Förhandsgranskare)
1 dec 201529 jan 2016

Aktivitet: ExaminationstyperFörhandsgranskare av doktorsavhandling

Pharmacology, Biochemistry and Behavior (Tidskrift)

Anni-Maija Linden (Referentgranskare)
1 jan 201530 dec 2015

Aktivitet: Typer för peer review av output och redaktionsarbeteReferentgranskning av manuskript

Pre-examiner of doctoral thesis

Anni-Maija Linden (Förhandsgranskare)
15 sep 201514 okt 2015

Aktivitet: ExaminationstyperFörhandsgranskare av doktorsavhandling

Supervision of PhD thesis work

Anni-Maija Linden (Bihandledare)
30 okt 2015

Aktivitet: ExaminationstyperHandledare eller bihandledare av doktorsavhandling