Inget foto på Brendan Battersby

Brendan Battersby, Research Director

  • PL 56 (Viikinkaari 5)

    00014

    Finland

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

19962019
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Publikationer 1996 2019

2019

A variant in MRPS14 (uS14m) causes perinatal hypertrophic cardiomyopathy with neonatal lactic acidosis, growth retardation, dysmorphic features and neurological involvement

Jackson, C. B., Huemer, M., Bolognini, R., Martin, F., Szinnai, G., Donner, B. C., Richter, U., Battersby, B. J., Nuoffer, J-M., Suomalainen, A. & Schaller, A., 15 feb 2019, I : Human Molecular Genetics. 28, 4, s. 639-649 11 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2018

Mice harbouring a SCA28 patient mutation in AFG3L2 develop late-onset ataxia associated with enhanced mitochondrial proteotoxicity

Mancini, C., Hoxha, E., Iommarini, L., Brussino, A., Richter, U., Montarolo, F., Cagnoli, C., Parolisi, R., Gondor Morosini, D. I., Nicolò, V., Maltecca, F., Muratori, L., Ronchi, G., Geuna, S., Arnaboldi, F., Donetti, E., Giorgio, E., Cavalieri, S., Di Gregorio, E., Pozzi, E. & 11 andraFerrero, M., Riberi, E., Casari, G., Altruda, F., Turco, E., Gasparre, G., Battersby, B. J., Porcelli, A. M., Ferrero, E., Brusco, A. & Tempia, F., 1 okt 2018, I : Neurobiology of Disease. 124, s. 14-28 15 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Mitochondrial diseases: the contribution of organelle stress responses to pathology

Suomalainen, A. & Battersby, B. J., 1 feb 2018, I : Nature Reviews. Molecular Cell Biology. 19, 2, s. 77-92 16 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

OXA1L mutations cause mitochondrial encephalopathy and a combined oxidative phosphorylation defect

Thompson, K., Mai, N., Oláhová, M., Scialó, F., Formosa, L. E., Stroud, D. A., Garrett, M., Lax, N. Z., Robertson, F. M., Jou, C., Nascimento, A., Ortez, C., Jimenez-Mallebrera, C., Hardy, S. A., He, L., Brown, G. K., Marttinen, P., McFarland, R., Sanz, A., Battersby, B. J. & 5 andraBonnen, P. E., Ryan, M. T., Chrzanowska-Lightowlers, Z. M., Lightowlers, R. N. & Taylor, R. W., 1 nov 2018, I : EMBO molecular medicine. 10, 11, 13 s., e9060.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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RNA modification landscape of the human mitochondrial tRNA(LYs) regulates protein synthesis

Richter, U., Evans, M. E., Clark, W. C., Marttinen, P., Shoubridge, E. A., Suomalainen, A., Wredenberg, A., Wedell, A., Pan, T. & Battersby, B. J., 27 sep 2018, I : Nature Communications. 9, 11 s., 3966.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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2017

A novel mitochondrial ATP6 frameshift mutation causing isolated complex V deficiency, ataxia and encephalomyopathy

Jackson, C. B., Hahn, D., Schroter, B., Richter, U., Battersby, B. J., Schmitt-Mechelke, T., Marttinen, P., Nuoffer, J-M. & Schaller, A., jun 2017, I : European Journal of Medical Genetics. 60, 6, s. 345-351 7 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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2016

Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism

Nikkanen, J., Forsstrom, S., Euro, L., Paetau, I., Kohnz, R. A., Wang, L., Chilov, D., Viinamaki, J., Roivainen, A., Marjamaki, P., Liljenback, H., Ahola, S., Buzkova, J., Terzioglu, M., Khan, N. A., Pirnes-Karhu, S., Paetau, A., Lonnqvist, T., Sajantila, A., Isohanni, P. & 6 andraTyynismaa, H., Nomura, D. K., Battersby, B. J., Velagapudi, V., Carroll, C. J. & Suomalainen, A., 12 apr 2016, I : Cell Metabolism. 23, 4, s. 635-648 14 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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Tissue-specific modulation of mitochondrial DNA segregation by a defect in mitochondrial division

Jokinen, R., Marttinen, P., Stewart, J. B., Dear, T. N. & Battersby, B. J., 15 feb 2016, I : Human Molecular Genetics. 25, 4, s. 706-714 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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2015

Quality control of mitochondrial protein synthesis is required for membrane integrity and cell fitness

Richter, U., Lahtinen, T., Marttinen, P., Suomi, F. & Battersby, B. J., 26 okt 2015, I : Journal of Cell Biology. 211, 2, s. 373-389 17 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Quantitative Changes in Gimap3 and Gimap5 Expression Modify Mitochondrial DNA Segregation in Mice

Jokinen, R., Lahtinen, T., Marttinen, P., Myohanen, M., Ruotsalainen, P., Yeung, N., Shvetsova, A., Kastaniotis, A. J., Hiltunen, J. K., Ohman, T., Nyman, T. A., Weiler, H. & Battersby, B. J., maj 2015, I : Genetics. 200, 1, s. 221-U419 20 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2014

No recombination of mtDNA after heteroplasmy for 50 generations in the mouse maternal germline

Hagstrom, E., Freyer, C., Battersby, B. J., Stewart, J. B. & Larsson, N-G., jan 2014, I : Nucleic Acids Research. 42, 2, s. 1111-1116 6 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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2013

A Mitochondrial Ribosomal and RNA Decay Pathway Blocks Cell Proliferation

Richter, U., Lahtinen, T., Marttinen, P., Myohanen, M., Greco, D., Cannino, G., Jacobs, H. T., Lietzen, N., Nyman, T. A. & Battersby, B. J., 18 mar 2013, I : Current Biology. 23, 6, s. 535-541 7 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Insight into mammalian mitochondrial DNA segregation

Jokinen, R. & Battersby, B. J., 1 mar 2013, I : Annals of Medicine. 45, 2, s. 149-155 7 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Whole-exome sequencing identifies a mutation in the mitochondrial ribosome protein MRPL44 to underlie mitochondrial infantile cardiomyopathy

Carroll, C. J., Isohanni, P., Poyhonen, R., Euro, L., Richter, U., Brilhante, V., Gotz, A., Lahtinen, T., Paetau, A., Pihko, H., Battersby, B. J., Tyynismaa, H. & Suomalainen, A., mar 2013, I : Journal of Medical Genetics. 50, 3, s. 151-159 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2011

Gimap3: a foot-in-the-door to tissue-specific regulation of mitochondrial DNA genetics

Jokinen, R., Junnila, H. & Battersby, B., 2011, I : Small GTPases. 2, 1, s. 31-35 5 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2010

Gimap3 Regulates Tissue-Specific Mitochondrial DNA Segregation

Jokinen, R., Marttinen, P., Sandell, H. K., Manninen, T., Teerenhovi, H., Wai, T., Teoli, D., Loredo-Osti, J. C., Shoubridge, E. A. & Battersby, B. J., 2010, I : PLoS Genetics. 6, 10 , s. e1001161 9 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

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2007

Reactive oxygen species and the segregation of mtDNA sequence variants

Battersby, B. J. & Shoubridge, E. A., 2007, I : Nature Genetics. 39, 5, s. 571-572 2 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2005

Mitochondrial DNA segregation in hematopoietic lineages does not depend on MHC presentation of mitochondrially-encoded peptides

Battersby, B., Redpath, M. E. & Shoubridge, E. A., 2005, I : Human Molecular Genetics. 14, 17, s. 2587-2594

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Rapid directional shift of mitochondrial DNA heteroplasmy in animal tissues by a mitochondrially targeted restriction endonuclease

Bayona-Bafaluy, M. P., Blits, B., Battersby, B. J., Shoubridge, E. A. & Moraes, C. T., 2005, I : Proceedings of the National Academy of Sciences of the United States of America. 102, 40, s. 14392-14397 6 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2003

Nuclear genetic control of mitochondrial DNA segregation

Battersby, BJ., Loredo-Osti, JC. & Shoubridge, EA., feb 2003, I : Nature Genetics. 33, 2, s. 183-186 4 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Prospect of preimplantation genetic diagnosis for heritable mitochondrial DNA diseases

Dean, NL., Battersby, BJ., Ao, A., Gosden, RG., Tan, SL. & Shoubridge, EA., 1 okt 2003, I : Molecular Human Reproduction. 9, 10, s. 631-638 8 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

2001

Correlations of plasma lipid metabolites with hibernation and lactation in wild black bears Ursus americanus

LeBlanc, PJ., Obbard, M., Battersby, BJ., Felskie, AK., Brown, L., Wright, PA. & Ballantyne, JS., maj 2001, I : Journal of comparative physiology. B, Biochemical, systems, and environmental physiology. 171, 4, s. 327-334 8 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Selection of a mtDNA sequence variant in hepatocytes of heteroplasmic mice is not due to differences in respiratory chain function or efficiency of replication

Battersby, BJ. & Shoubridge, EA., 15 okt 2001, I : Human Molecular Genetics. 10, 22, s. 2469-2479 11 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

1999

Lactation during hibernation in wild black bears: Effects on plasma amino acids and nitrogen metabolites

Wright, PA., Obbard, ME., Battersby, BJ., Felskie, AK., LeBlanc, PJ. & Ballantyne, JS., 1999, I : Physiological and Biochemical Zoology. 72, 5, s. 597-604 8 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

1998

Are there distinct subcellular populations of mitochondria in rainbow trout red muscle?

Battersby, BJ. & Moyes, CD., aug 1998, I : Journal of Experimental Biology. 201, 16, s. 2455-2460 6 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Influence of acclimation temperature on mitochondrial DNA, RNA, and enzymes in skeletal muscle

Battersby, BJ. & Moyes, CD., sep 1998, I : American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 275, 3, s. R905-R912 8 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Inter-tissue differences in mitochondrial enzyme activity, RNA and DNA in rainbow trout (Oncorhynchus mykiss)

Leary, SC., Battersby, BJ. & Moyes, CD., dec 1998, I : Journal of Experimental Biology. 201, 24, s. 3377-3384 8 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Regulation of muscle mitochondrial design

Moyes, CD., Battersby, BJ. & Leary, SC., feb 1998, I : Journal of Experimental Biology. 201, 3, s. 299-307 9 s.

Forskningsoutput: TidskriftsbidragÖversiktsartikelVetenskapligPeer review

1997

Short-term effects of 3,5,3'-triiodothyronine on the activity of selected enzymes of intermediary metabolism in the liver of the Atlantic hagfish, Myxine glutinosa

Leary, SC., Reddy, K., Battersby, BJ., Dugan, S. & Ballantyne, JS., 1 aug 1997, I : Journal of Experimental Zoology. 278, 5, s. 333-337 5 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

1996

Short-term effects of 3,5,3'-triiodothyronine on the intermediary metabolism of the dogfish shark Squalus acanthias: Evidence from enzyme activities

Battersby, BJ., McFarlane, WJ. & Ballantyne, JS., 15 feb 1996, I : Journal of Experimental Zoology. 274, 3, s. 157-162 6 s.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review